Multi Simulation Platform for Time Domain Diffuse Optical Tomography: An Application to a Compact Hand-Held Reflectance Probe
Time Domain Diffuse Optical Tomography (TD-DOT) enables a full 3D reconstruction of the optical properties of tissue, and could be used for non-invasive and cost-effective in-depth body exploration (e.g., thyroid and breast imaging). Performance quantification is crucial for comparing results coming...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-07-01
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| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/9/14/2849 |
| Summary: | Time Domain Diffuse Optical Tomography (TD-DOT) enables a full 3D reconstruction of the optical properties of tissue, and could be used for non-invasive and cost-effective in-depth body exploration (e.g., thyroid and breast imaging). Performance quantification is crucial for comparing results coming from different implementations of this technique. A general-purpose simulation platform for TD-DOT clinical systems was developed with a focus on performance assessment through meaningful figures of merit. The platform was employed for assessing the feasibility and characterizing a compact hand-held probe for breast imaging and characterization in reflectance geometry. Important parameters such as hardware gating of the detector, photon count rate and inclusion position were investigated. Results indicate a reduced error (<10%) on the absorption coefficient quantification of a simulated inclusion up to 2-cm depth if a photon count rate ≥ 10<sup>6</sup> counts per second is used along with a good localization (error < 1 mm down to 25 mm-depth). |
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| ISSN: | 2076-3417 |