Dynamic changes in the transcriptome of tRNA-derived small RNAs related with fat metabolism
Abstract The prevalence of obesity and overweight is steadily rising, posing a significant global challenge for humanity. The fundamental cause of obesity and overweight lies in the abnormal accumulation of adipose tissue. While numerous regulatory factors related to fat deposition have been identif...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-10-01
|
| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-023-02624-y |
| _version_ | 1797453986049032192 |
|---|---|
| author | Tianci Liao Mailin Gan Yuhang Lei Yan Wang Lei Chen Linyuan Shen Li Zhu |
| author_facet | Tianci Liao Mailin Gan Yuhang Lei Yan Wang Lei Chen Linyuan Shen Li Zhu |
| author_sort | Tianci Liao |
| collection | DOAJ |
| description | Abstract The prevalence of obesity and overweight is steadily rising, posing a significant global challenge for humanity. The fundamental cause of obesity and overweight lies in the abnormal accumulation of adipose tissue. While numerous regulatory factors related to fat deposition have been identified in previous studies, a considerable number of regulatory mechanisms remain unknown. tRNA-derived small RNAs (tsRNAs), a novel class of non-coding RNAs, have emerged as significant regulators in various biological processes. In this study, we obtained small RNA sequencing data from subcutaneous white adipose tissue and omental white adipose tissue of lean and obese pigs. In addition, we similarly obtained tsRNAs profiles from scapular brown adipose tissue (BAT), inguinal white adipose tissue (iWAT) and epigonadal white adipose tissue (eWAT) of normal mice. Finally, we successfully identified a large number of expressed tsRNAs in each tissue type and identified tsRNAs conserved in different adipose tissues of pigs and mice. These datasets will be a valuable resource for elucidating the epigenetic mechanisms of fat deposition. |
| first_indexed | 2024-03-09T15:30:43Z |
| format | Article |
| id | doaj.art-f160161904884337967753f941a92c7c |
| institution | Directory Open Access Journal |
| issn | 2052-4463 |
| language | English |
| last_indexed | 2024-03-09T15:30:43Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Data |
| spelling | doaj.art-f160161904884337967753f941a92c7c2023-11-26T12:17:44ZengNature PortfolioScientific Data2052-44632023-10-0110111010.1038/s41597-023-02624-yDynamic changes in the transcriptome of tRNA-derived small RNAs related with fat metabolismTianci Liao0Mailin Gan1Yuhang Lei2Yan Wang3Lei Chen4Linyuan Shen5Li Zhu6Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityAbstract The prevalence of obesity and overweight is steadily rising, posing a significant global challenge for humanity. The fundamental cause of obesity and overweight lies in the abnormal accumulation of adipose tissue. While numerous regulatory factors related to fat deposition have been identified in previous studies, a considerable number of regulatory mechanisms remain unknown. tRNA-derived small RNAs (tsRNAs), a novel class of non-coding RNAs, have emerged as significant regulators in various biological processes. In this study, we obtained small RNA sequencing data from subcutaneous white adipose tissue and omental white adipose tissue of lean and obese pigs. In addition, we similarly obtained tsRNAs profiles from scapular brown adipose tissue (BAT), inguinal white adipose tissue (iWAT) and epigonadal white adipose tissue (eWAT) of normal mice. Finally, we successfully identified a large number of expressed tsRNAs in each tissue type and identified tsRNAs conserved in different adipose tissues of pigs and mice. These datasets will be a valuable resource for elucidating the epigenetic mechanisms of fat deposition.https://doi.org/10.1038/s41597-023-02624-y |
| spellingShingle | Tianci Liao Mailin Gan Yuhang Lei Yan Wang Lei Chen Linyuan Shen Li Zhu Dynamic changes in the transcriptome of tRNA-derived small RNAs related with fat metabolism Scientific Data |
| title | Dynamic changes in the transcriptome of tRNA-derived small RNAs related with fat metabolism |
| title_full | Dynamic changes in the transcriptome of tRNA-derived small RNAs related with fat metabolism |
| title_fullStr | Dynamic changes in the transcriptome of tRNA-derived small RNAs related with fat metabolism |
| title_full_unstemmed | Dynamic changes in the transcriptome of tRNA-derived small RNAs related with fat metabolism |
| title_short | Dynamic changes in the transcriptome of tRNA-derived small RNAs related with fat metabolism |
| title_sort | dynamic changes in the transcriptome of trna derived small rnas related with fat metabolism |
| url | https://doi.org/10.1038/s41597-023-02624-y |
| work_keys_str_mv | AT tianciliao dynamicchangesinthetranscriptomeoftrnaderivedsmallrnasrelatedwithfatmetabolism AT mailingan dynamicchangesinthetranscriptomeoftrnaderivedsmallrnasrelatedwithfatmetabolism AT yuhanglei dynamicchangesinthetranscriptomeoftrnaderivedsmallrnasrelatedwithfatmetabolism AT yanwang dynamicchangesinthetranscriptomeoftrnaderivedsmallrnasrelatedwithfatmetabolism AT leichen dynamicchangesinthetranscriptomeoftrnaderivedsmallrnasrelatedwithfatmetabolism AT linyuanshen dynamicchangesinthetranscriptomeoftrnaderivedsmallrnasrelatedwithfatmetabolism AT lizhu dynamicchangesinthetranscriptomeoftrnaderivedsmallrnasrelatedwithfatmetabolism |