Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trial
Background: Medicines in indigenous systems such as Ayurveda have strong antimicrobial activity but double-blind randomized control trials are infrequent in this system of medicine. The efficacy of a new ayurvedic formulation was evaluated during the pandemic. Methods: 150 mild-moderate COVID-19 pat...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Journal of Ayurveda and Integrative Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0975947623000943 |
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| author | Pankaj Bhardwaj Kalaiselvan Ganapathy Monika Pathania K.H. Naveen Jaykaran Charan Siddhartha Dutta Ravisekhar Gadepalli Srikanth Srinivasan Manoj Kumar Gupta Akhil D. Goel Naresh Midha Bharat Kumar Meenakshi Sharma Praveen Sharma Mithu Banerjee Prasenjit Mitra Sanjeev Misra Vinayagamoorthy V Girija Subramaniant Praveen R Minakshi Dhar Vartika Saxena Puneet Dhamija Archana Singh Saumya Subramanian Divya Kanchibhotla |
| author_facet | Pankaj Bhardwaj Kalaiselvan Ganapathy Monika Pathania K.H. Naveen Jaykaran Charan Siddhartha Dutta Ravisekhar Gadepalli Srikanth Srinivasan Manoj Kumar Gupta Akhil D. Goel Naresh Midha Bharat Kumar Meenakshi Sharma Praveen Sharma Mithu Banerjee Prasenjit Mitra Sanjeev Misra Vinayagamoorthy V Girija Subramaniant Praveen R Minakshi Dhar Vartika Saxena Puneet Dhamija Archana Singh Saumya Subramanian Divya Kanchibhotla |
| author_sort | Pankaj Bhardwaj |
| collection | DOAJ |
| description | Background: Medicines in indigenous systems such as Ayurveda have strong antimicrobial activity but double-blind randomized control trials are infrequent in this system of medicine. The efficacy of a new ayurvedic formulation was evaluated during the pandemic. Methods: 150 mild-moderate COVID-19 patients were enrolled and randomized in 1:1 to NAOQ19 and placebo group. RT-PCR was done on Day 3, 5 and 7. CBC, CRP, LFT, and KFT were assessed at baseline and exit. Duration of hospital stay was noted and clinical assessment was also performed. Result: The results demonstrated more people turning RT-PCR negative in the NAOQ19 group compared to the placebo group on day 3 (p-value = 0.033). The mean time duration to turn RT-PCR negative was significantly lower in the NAOQ19 group (4.6 days) compared to placebo group (5.2 days) (p-value = 0.018). There was significant reduction in hospital stay among patients in the NAOQ19 arm who were discharged earlier (5.6 days) compared to placebo group (6.4 days) (p-value = 0.046). Patients in NAOQ19 arm did not show any adverse life-threatening events. Conclusion: The ayurvedic preparation given along with standard of care therapy reduced the duration of hospital stay and there was earlier conversion to RT-PCR negative.The integrated approach can help to reduce patient workload in the hospitals as well as limit the transmission of the virus in the community. Study registration: CTRI/2021/05/033790. |
| first_indexed | 2024-03-08T19:02:21Z |
| format | Article |
| id | doaj.art-f16096152c5944f4b706070d01860fdf |
| institution | Directory Open Access Journal |
| issn | 0975-9476 |
| language | English |
| last_indexed | 2024-03-08T19:02:21Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ayurveda and Integrative Medicine |
| spelling | doaj.art-f16096152c5944f4b706070d01860fdf2023-12-28T05:14:37ZengElsevierJournal of Ayurveda and Integrative Medicine0975-94762023-11-01146100778Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trialPankaj Bhardwaj0Kalaiselvan Ganapathy1Monika Pathania2K.H. Naveen3Jaykaran Charan4Siddhartha Dutta5Ravisekhar Gadepalli6Srikanth Srinivasan7Manoj Kumar Gupta8Akhil D. Goel9Naresh Midha10Bharat Kumar11Meenakshi Sharma12Praveen Sharma13Mithu Banerjee14Prasenjit Mitra15Sanjeev Misra16Vinayagamoorthy V17Girija Subramaniant18Praveen R19Minakshi Dhar20Vartika Saxena21Puneet Dhamija22Archana Singh23Saumya Subramanian24Divya Kanchibhotla25Department of CMFM, AIIMS Jodhpur, IndiaDepartment of Community Medicine, SMVMCH Puducherry, IndiaDepartment of Medicine, AIIMS Rishikesh, IndiaDepartment of CMFM, AIIMS Jodhpur, IndiaDepartment of Pharmacology, AIIMS Jodhpur, IndiaDepartment of Pharmacology, AIIMS Jodhpur, IndiaDepartment of Microbiology, AIIMS Jodhpur, IndiaDepartment of CMFM, AIIMS Jodhpur, IndiaDepartment of CMFM, AIIMS Jodhpur, IndiaDepartment of CMFM, AIIMS Jodhpur, IndiaDepartment of General Medicine, AIIMS Jodhpur, IndiaDepartment of General Medicine, AIIMS Jodhpur, IndiaDepartment of AYUSH, AIIMS Jodhpur, IndiaDepartment of Biochemistry, AIIMS Jodhpur, IndiaDepartment of Biochemistry, AIIMS Jodhpur, IndiaDepartment of Biochemistry, AIIMS Jodhpur, IndiaAIIMS Jodhpur, IndiaDepartment of Community Medicine, SMVMCH Puducherry, IndiaDepartment of General Medicine, SMVMCH Puducherry, IndiaDepartment of Respiratory Medicine, SMVMCH Puducherry, IndiaDepartment of Medicine, AIIMS Rishikesh, IndiaDepartment of CFM &AYUSH, AIIMS Rishikesh, IndiaDepartment of Pharmacology, AIIMS Rishikesh, IndiaDepartment of Shalya Tantra, AIIMS Rishikesh, IndiaSri Sri Institute for Advanced Research, IndiaSri Sri Institute for Advanced Research, India; Corresponding author. 21st Km Kanakapura Rd, Udaypura, Bangalore, Karnataka 560082, India.Background: Medicines in indigenous systems such as Ayurveda have strong antimicrobial activity but double-blind randomized control trials are infrequent in this system of medicine. The efficacy of a new ayurvedic formulation was evaluated during the pandemic. Methods: 150 mild-moderate COVID-19 patients were enrolled and randomized in 1:1 to NAOQ19 and placebo group. RT-PCR was done on Day 3, 5 and 7. CBC, CRP, LFT, and KFT were assessed at baseline and exit. Duration of hospital stay was noted and clinical assessment was also performed. Result: The results demonstrated more people turning RT-PCR negative in the NAOQ19 group compared to the placebo group on day 3 (p-value = 0.033). The mean time duration to turn RT-PCR negative was significantly lower in the NAOQ19 group (4.6 days) compared to placebo group (5.2 days) (p-value = 0.018). There was significant reduction in hospital stay among patients in the NAOQ19 arm who were discharged earlier (5.6 days) compared to placebo group (6.4 days) (p-value = 0.046). Patients in NAOQ19 arm did not show any adverse life-threatening events. Conclusion: The ayurvedic preparation given along with standard of care therapy reduced the duration of hospital stay and there was earlier conversion to RT-PCR negative.The integrated approach can help to reduce patient workload in the hospitals as well as limit the transmission of the virus in the community. Study registration: CTRI/2021/05/033790.http://www.sciencedirect.com/science/article/pii/S0975947623000943SARS-CoV-2Viral illnessFlu like symptomsCoronavirusAyurvedaCovid-19 pandemic |
| spellingShingle | Pankaj Bhardwaj Kalaiselvan Ganapathy Monika Pathania K.H. Naveen Jaykaran Charan Siddhartha Dutta Ravisekhar Gadepalli Srikanth Srinivasan Manoj Kumar Gupta Akhil D. Goel Naresh Midha Bharat Kumar Meenakshi Sharma Praveen Sharma Mithu Banerjee Prasenjit Mitra Sanjeev Misra Vinayagamoorthy V Girija Subramaniant Praveen R Minakshi Dhar Vartika Saxena Puneet Dhamija Archana Singh Saumya Subramanian Divya Kanchibhotla Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trial Journal of Ayurveda and Integrative Medicine SARS-CoV-2 Viral illness Flu like symptoms Coronavirus Ayurveda Covid-19 pandemic |
| title | Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trial |
| title_full | Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trial |
| title_fullStr | Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trial |
| title_full_unstemmed | Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trial |
| title_short | Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trial |
| title_sort | effectiveness of ayurvedic formulation naoq19 along with standard care in the treatment of mild moderate covid 19 patients a double blind randomized placebo controlled multicentric trial |
| topic | SARS-CoV-2 Viral illness Flu like symptoms Coronavirus Ayurveda Covid-19 pandemic |
| url | http://www.sciencedirect.com/science/article/pii/S0975947623000943 |
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