Cognitive Performance Concomitant With Vision Acuity Predicts 13-Year Risk for Mortality
Objective: To assess the joint impact of cognitive performance and visual acuity on mortality over 13-year follow-up in a representative US sample.Methods: Data from National Health and Nutrition Examination Survey (NHANES) participants (≥18 years old) were linked with the death record data of the N...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2019.00065/full |
| _version_ | 1818111100717105152 |
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| author | Huan Liao Huan Liao Zhuoting Zhu Hongxuan Wang Hongxuan Wang Xiaoming Rong Xiaoming Rong Charlotte Aimee Young Ying Peng Ying Peng |
| author_facet | Huan Liao Huan Liao Zhuoting Zhu Hongxuan Wang Hongxuan Wang Xiaoming Rong Xiaoming Rong Charlotte Aimee Young Ying Peng Ying Peng |
| author_sort | Huan Liao |
| collection | DOAJ |
| description | Objective: To assess the joint impact of cognitive performance and visual acuity on mortality over 13-year follow-up in a representative US sample.Methods: Data from National Health and Nutrition Examination Survey (NHANES) participants (≥18 years old) were linked with the death record data of the National Death Index (NDI) with mortality follow-up through December 31, 2011. Cognitive performance was evaluated by the Digit Symbol Substitution Test (DSST) and cognitive performance impairment was defined as the DSST score equal to or less than the median value in the study population. Visual impairment (VI) was defined as presenting visual acuity worse than 20/40 in the better-seeing eye. Risks of all-cause and specific-cause mortality were estimated with Cox proportional hazards models after adjusting for confounders.Results: A total of 2,550 participants 60 years and older from two waves of (NHANES, 1999–2000, 2001–2002) were included in the current analysis. Over a median follow-up period of 9.92 years, 952 (35.2%) died of all causes, of whom 239 (23.1%), 224 (24.0%), and 489 (52.9%) died from cardiovascular disease (CVD), cancer, and non-CVD/non-cancer mortality, respectively. Cognitive performance impairment and VI increased the odds for mortality. Co-presence of VI among cognitive impaired elderly persons predicted nearly a threefold increased risk of all-cause mortality [hazard ratios (HRs), 2.74; 95% confidence interval (CI), 2.02–3.70; P < 0.001) and almost a fourfold higher risk of non-CVD/non-cancer mortality (HR, 3.72; 95% CI, 2.30–6.00; P < 0.001) compared to having neither impairment.Conclusion: People aged 60 years and over with poorer cognitive performance were at higher risk of long-term mortality, and were especially vulnerable to further mortality when concomitant with VI. It is informative for clinical implication in terms of early preventive interventions. |
| first_indexed | 2024-12-11T02:57:41Z |
| format | Article |
| id | doaj.art-f163b0f84ab5408ba1333bdaa781819d |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-11T02:57:41Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-f163b0f84ab5408ba1333bdaa781819d2022-12-22T01:23:07ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652019-03-011110.3389/fnagi.2019.00065430627Cognitive Performance Concomitant With Vision Acuity Predicts 13-Year Risk for MortalityHuan Liao0Huan Liao1Zhuoting Zhu2Hongxuan Wang3Hongxuan Wang4Xiaoming Rong5Xiaoming Rong6Charlotte Aimee Young7Ying Peng8Ying Peng9Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaDepartment of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaObjective: To assess the joint impact of cognitive performance and visual acuity on mortality over 13-year follow-up in a representative US sample.Methods: Data from National Health and Nutrition Examination Survey (NHANES) participants (≥18 years old) were linked with the death record data of the National Death Index (NDI) with mortality follow-up through December 31, 2011. Cognitive performance was evaluated by the Digit Symbol Substitution Test (DSST) and cognitive performance impairment was defined as the DSST score equal to or less than the median value in the study population. Visual impairment (VI) was defined as presenting visual acuity worse than 20/40 in the better-seeing eye. Risks of all-cause and specific-cause mortality were estimated with Cox proportional hazards models after adjusting for confounders.Results: A total of 2,550 participants 60 years and older from two waves of (NHANES, 1999–2000, 2001–2002) were included in the current analysis. Over a median follow-up period of 9.92 years, 952 (35.2%) died of all causes, of whom 239 (23.1%), 224 (24.0%), and 489 (52.9%) died from cardiovascular disease (CVD), cancer, and non-CVD/non-cancer mortality, respectively. Cognitive performance impairment and VI increased the odds for mortality. Co-presence of VI among cognitive impaired elderly persons predicted nearly a threefold increased risk of all-cause mortality [hazard ratios (HRs), 2.74; 95% confidence interval (CI), 2.02–3.70; P < 0.001) and almost a fourfold higher risk of non-CVD/non-cancer mortality (HR, 3.72; 95% CI, 2.30–6.00; P < 0.001) compared to having neither impairment.Conclusion: People aged 60 years and over with poorer cognitive performance were at higher risk of long-term mortality, and were especially vulnerable to further mortality when concomitant with VI. It is informative for clinical implication in terms of early preventive interventions.https://www.frontiersin.org/article/10.3389/fnagi.2019.00065/fullcognitive performancevision acuityjoint impactmortalityNHANES |
| spellingShingle | Huan Liao Huan Liao Zhuoting Zhu Hongxuan Wang Hongxuan Wang Xiaoming Rong Xiaoming Rong Charlotte Aimee Young Ying Peng Ying Peng Cognitive Performance Concomitant With Vision Acuity Predicts 13-Year Risk for Mortality Frontiers in Aging Neuroscience cognitive performance vision acuity joint impact mortality NHANES |
| title | Cognitive Performance Concomitant With Vision Acuity Predicts 13-Year Risk for Mortality |
| title_full | Cognitive Performance Concomitant With Vision Acuity Predicts 13-Year Risk for Mortality |
| title_fullStr | Cognitive Performance Concomitant With Vision Acuity Predicts 13-Year Risk for Mortality |
| title_full_unstemmed | Cognitive Performance Concomitant With Vision Acuity Predicts 13-Year Risk for Mortality |
| title_short | Cognitive Performance Concomitant With Vision Acuity Predicts 13-Year Risk for Mortality |
| title_sort | cognitive performance concomitant with vision acuity predicts 13 year risk for mortality |
| topic | cognitive performance vision acuity joint impact mortality NHANES |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2019.00065/full |
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