The Prognostic Significance of Neutrophil to Lymphocyte Ratio (NLR), Monocyte to Lymphocyte Ratio (MLR) and Platelet to Lymphocyte Ratio (PLR) on Long-Term Survival in Off-Pump Coronary Artery Bypass Grafting (OPCAB) Procedures
Background: Cardiovascular diseases, apart from commonly known risk factors, are related to inflammation. There are several simple novel markers proposed to present the relation between inflammatory reactions activation and atherosclerotic changes. They are easily available from whole blood count an...
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MDPI AG
2021-12-01
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| Online Access: | https://www.mdpi.com/2079-7737/11/1/34 |
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| author | Tomasz Urbanowicz Anna Olasińska-Wiśniewska Michał Michalak Michał Rodzki Anna Witkowska Ewa Straburzyńska-Migaj Bartłomiej Perek Marek Jemielity |
| author_facet | Tomasz Urbanowicz Anna Olasińska-Wiśniewska Michał Michalak Michał Rodzki Anna Witkowska Ewa Straburzyńska-Migaj Bartłomiej Perek Marek Jemielity |
| author_sort | Tomasz Urbanowicz |
| collection | DOAJ |
| description | Background: Cardiovascular diseases, apart from commonly known risk factors, are related to inflammation. There are several simple novel markers proposed to present the relation between inflammatory reactions activation and atherosclerotic changes. They are easily available from whole blood count and include neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), and platelets to lymphocyte ratio (PLR). The RDW results were excluded from the analysis. Method and results: The study based on retrospective single-centre analysis of 682 consecutive patients (131 (19%) females and 551 (81%) males) with median age of 66 years (60–71) who underwent off-pump coronary artery bypass grafting (OPCAB) procedure. During the median 5.3 +/− 1.9 years follow-up, there was a 87% cumulative survival rate. The laboratory parameters including preoperative MLR > 0.2 (HR 2.46, 95% CI 1.33–4.55, <i>p</i> = 0.004) and postoperative NLR > 3.5 (HR 1.75, 95% CI 1.09–2.79, <i>p</i> = 0.019) were found significant for long-term mortality prediction in multivariable analysis. Conclusion: Hematological indices NLR and MLR can be regarded as significant predictors of all-cause long-term mortality after OPCAB revascularization. Multivariable analysis revealed preoperative values of MLR > 0.2 and postoperative values of NLR > 3.5 as simple, reliable factors which may be applied into clinical practice for meticulous postoperative monitoring of patients in higher risk of worse prognosis. |
| first_indexed | 2024-03-10T01:54:31Z |
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| spelling | doaj.art-f163b3d8c4554ebab144001b75c8575b2023-11-23T13:00:03ZengMDPI AGBiology2079-77372021-12-011113410.3390/biology11010034The Prognostic Significance of Neutrophil to Lymphocyte Ratio (NLR), Monocyte to Lymphocyte Ratio (MLR) and Platelet to Lymphocyte Ratio (PLR) on Long-Term Survival in Off-Pump Coronary Artery Bypass Grafting (OPCAB) ProceduresTomasz Urbanowicz0Anna Olasińska-Wiśniewska1Michał Michalak2Michał Rodzki3Anna Witkowska4Ewa Straburzyńska-Migaj5Bartłomiej Perek6Marek Jemielity7Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, 60-806 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland1st Cardiology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandBackground: Cardiovascular diseases, apart from commonly known risk factors, are related to inflammation. There are several simple novel markers proposed to present the relation between inflammatory reactions activation and atherosclerotic changes. They are easily available from whole blood count and include neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), and platelets to lymphocyte ratio (PLR). The RDW results were excluded from the analysis. Method and results: The study based on retrospective single-centre analysis of 682 consecutive patients (131 (19%) females and 551 (81%) males) with median age of 66 years (60–71) who underwent off-pump coronary artery bypass grafting (OPCAB) procedure. During the median 5.3 +/− 1.9 years follow-up, there was a 87% cumulative survival rate. The laboratory parameters including preoperative MLR > 0.2 (HR 2.46, 95% CI 1.33–4.55, <i>p</i> = 0.004) and postoperative NLR > 3.5 (HR 1.75, 95% CI 1.09–2.79, <i>p</i> = 0.019) were found significant for long-term mortality prediction in multivariable analysis. Conclusion: Hematological indices NLR and MLR can be regarded as significant predictors of all-cause long-term mortality after OPCAB revascularization. Multivariable analysis revealed preoperative values of MLR > 0.2 and postoperative values of NLR > 3.5 as simple, reliable factors which may be applied into clinical practice for meticulous postoperative monitoring of patients in higher risk of worse prognosis.https://www.mdpi.com/2079-7737/11/1/34off-pump coronary artery bypass graftingneutrophil to lymphocyte ratiomonocyte to lymphocyte ratioplatelets to lymphocyte ratio |
| spellingShingle | Tomasz Urbanowicz Anna Olasińska-Wiśniewska Michał Michalak Michał Rodzki Anna Witkowska Ewa Straburzyńska-Migaj Bartłomiej Perek Marek Jemielity The Prognostic Significance of Neutrophil to Lymphocyte Ratio (NLR), Monocyte to Lymphocyte Ratio (MLR) and Platelet to Lymphocyte Ratio (PLR) on Long-Term Survival in Off-Pump Coronary Artery Bypass Grafting (OPCAB) Procedures Biology off-pump coronary artery bypass grafting neutrophil to lymphocyte ratio monocyte to lymphocyte ratio platelets to lymphocyte ratio |
| title | The Prognostic Significance of Neutrophil to Lymphocyte Ratio (NLR), Monocyte to Lymphocyte Ratio (MLR) and Platelet to Lymphocyte Ratio (PLR) on Long-Term Survival in Off-Pump Coronary Artery Bypass Grafting (OPCAB) Procedures |
| title_full | The Prognostic Significance of Neutrophil to Lymphocyte Ratio (NLR), Monocyte to Lymphocyte Ratio (MLR) and Platelet to Lymphocyte Ratio (PLR) on Long-Term Survival in Off-Pump Coronary Artery Bypass Grafting (OPCAB) Procedures |
| title_fullStr | The Prognostic Significance of Neutrophil to Lymphocyte Ratio (NLR), Monocyte to Lymphocyte Ratio (MLR) and Platelet to Lymphocyte Ratio (PLR) on Long-Term Survival in Off-Pump Coronary Artery Bypass Grafting (OPCAB) Procedures |
| title_full_unstemmed | The Prognostic Significance of Neutrophil to Lymphocyte Ratio (NLR), Monocyte to Lymphocyte Ratio (MLR) and Platelet to Lymphocyte Ratio (PLR) on Long-Term Survival in Off-Pump Coronary Artery Bypass Grafting (OPCAB) Procedures |
| title_short | The Prognostic Significance of Neutrophil to Lymphocyte Ratio (NLR), Monocyte to Lymphocyte Ratio (MLR) and Platelet to Lymphocyte Ratio (PLR) on Long-Term Survival in Off-Pump Coronary Artery Bypass Grafting (OPCAB) Procedures |
| title_sort | prognostic significance of neutrophil to lymphocyte ratio nlr monocyte to lymphocyte ratio mlr and platelet to lymphocyte ratio plr on long term survival in off pump coronary artery bypass grafting opcab procedures |
| topic | off-pump coronary artery bypass grafting neutrophil to lymphocyte ratio monocyte to lymphocyte ratio platelets to lymphocyte ratio |
| url | https://www.mdpi.com/2079-7737/11/1/34 |
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