Roles of circRNAs in hematological malignancies
Abstract As one of the leading causes of death, hematologic malignancies are associated with an ever-increasing incidence, and drug resistance and relapse of patients after treatment represent clinical challenges. Therefore, there are pressing demands to uncover biomarkers to indicate the developmen...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-022-00392-2 |
| _version_ | 1818474612075266048 |
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| author | Fahua Deng Chengsi Zhang Tingting Lu Ezhong Joshua Liao Hai Huang Sixi Wei |
| author_facet | Fahua Deng Chengsi Zhang Tingting Lu Ezhong Joshua Liao Hai Huang Sixi Wei |
| author_sort | Fahua Deng |
| collection | DOAJ |
| description | Abstract As one of the leading causes of death, hematologic malignancies are associated with an ever-increasing incidence, and drug resistance and relapse of patients after treatment represent clinical challenges. Therefore, there are pressing demands to uncover biomarkers to indicate the development, progression, and therapeutic targets for hematologic malignancies. Circular RNAs (circRNAs) are covalently closed circular-single-stranded RNAs whose biosynthesis is regulated by various factors and is widely-expressed and evolutionarily conserved in many organisms and expressed in a tissue−/cell-specific manner. Recent reports have indicated that circRNAs plays an essential role in the progression of hematological malignancies. However, circRNAs are difficult to detect with low abundance using conventional techniques. We need to learn more information about their features to develop new detection methods. Herein, we sought to retrospect the current knowledge about the characteristics of circRNAs and summarized research on circRNAs in hematological malignancies to explore a potential direction. |
| first_indexed | 2024-04-14T04:38:37Z |
| format | Article |
| id | doaj.art-f1640d82f979472fbc1fc507550f3cca |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-04-14T04:38:37Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-f1640d82f979472fbc1fc507550f3cca2022-12-22T02:11:46ZengBMCBiomarker Research2050-77712022-07-0110111310.1186/s40364-022-00392-2Roles of circRNAs in hematological malignanciesFahua Deng0Chengsi Zhang1Tingting Lu2Ezhong Joshua Liao3Hai Huang4Sixi Wei5Department of Clinical Biochemistry, School of Clinical Laboratory Science, Guizhou Medical UniversityDepartment of Clinical Biochemistry, School of Clinical Laboratory Science, Guizhou Medical UniversityDepartment of Clinical Biochemistry, School of Clinical Laboratory Science, Guizhou Medical UniversityCenter for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical UniversityDepartment of Clinical Biochemistry, School of Clinical Laboratory Science, Guizhou Medical UniversityDepartment of Clinical Biochemistry, School of Clinical Laboratory Science, Guizhou Medical UniversityAbstract As one of the leading causes of death, hematologic malignancies are associated with an ever-increasing incidence, and drug resistance and relapse of patients after treatment represent clinical challenges. Therefore, there are pressing demands to uncover biomarkers to indicate the development, progression, and therapeutic targets for hematologic malignancies. Circular RNAs (circRNAs) are covalently closed circular-single-stranded RNAs whose biosynthesis is regulated by various factors and is widely-expressed and evolutionarily conserved in many organisms and expressed in a tissue−/cell-specific manner. Recent reports have indicated that circRNAs plays an essential role in the progression of hematological malignancies. However, circRNAs are difficult to detect with low abundance using conventional techniques. We need to learn more information about their features to develop new detection methods. Herein, we sought to retrospect the current knowledge about the characteristics of circRNAs and summarized research on circRNAs in hematological malignancies to explore a potential direction.https://doi.org/10.1186/s40364-022-00392-2circRNAsNon-coding RNAscircRNA functionsHematological malignancies |
| spellingShingle | Fahua Deng Chengsi Zhang Tingting Lu Ezhong Joshua Liao Hai Huang Sixi Wei Roles of circRNAs in hematological malignancies Biomarker Research circRNAs Non-coding RNAs circRNA functions Hematological malignancies |
| title | Roles of circRNAs in hematological malignancies |
| title_full | Roles of circRNAs in hematological malignancies |
| title_fullStr | Roles of circRNAs in hematological malignancies |
| title_full_unstemmed | Roles of circRNAs in hematological malignancies |
| title_short | Roles of circRNAs in hematological malignancies |
| title_sort | roles of circrnas in hematological malignancies |
| topic | circRNAs Non-coding RNAs circRNA functions Hematological malignancies |
| url | https://doi.org/10.1186/s40364-022-00392-2 |
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