Alcohol-induced plasticity in the dynorphin / kappa-opioid receptor system
Alcoholism is a chronic relapsing disorder characterized by continued alcohol use despite numerous adverse consequences. Alcohol has been shown to interact with numerous neurotransmitter systems to exert its pharmacological effects. The endogenous opioid system has been strongly implicated in the po...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-09-01
|
| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00095/full |
| _version_ | 1818197274692419584 |
|---|---|
| author | Sunil eSirohi Georgy eBakalkin Brendan M. Walker |
| author_facet | Sunil eSirohi Georgy eBakalkin Brendan M. Walker |
| author_sort | Sunil eSirohi |
| collection | DOAJ |
| description | Alcoholism is a chronic relapsing disorder characterized by continued alcohol use despite numerous adverse consequences. Alcohol has been shown to interact with numerous neurotransmitter systems to exert its pharmacological effects. The endogenous opioid system has been strongly implicated in the positive and negative reinforcing effects of alcohol. Traditionally recognized as dysphoric/anhedonic in nature, the dynorphin/kappa-opioid receptor (DYN/KOR) system has recently received considerable attention due to evidence suggesting that an upregulated DYN/KOR system may be a critical contributor to the complex factors that result in escalated alcohol consumption once dependent. The present review will discuss alcohol-induced plasticity in the DYN/KOR system and how these neuroadaptations could contribute to excessive alcohol seeking and consumption. |
| first_indexed | 2024-12-12T01:47:23Z |
| format | Article |
| id | doaj.art-f164e472e8a147ed9a5093a7621af325 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-12T01:47:23Z |
| publishDate | 2012-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-f164e472e8a147ed9a5093a7621af3252022-12-22T00:42:33ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992012-09-01510.3389/fnmol.2012.0009528815Alcohol-induced plasticity in the dynorphin / kappa-opioid receptor systemSunil eSirohi0Georgy eBakalkin1Brendan M. Walker2Washington State UniversityUppsala UniversityWashington State UniversityAlcoholism is a chronic relapsing disorder characterized by continued alcohol use despite numerous adverse consequences. Alcohol has been shown to interact with numerous neurotransmitter systems to exert its pharmacological effects. The endogenous opioid system has been strongly implicated in the positive and negative reinforcing effects of alcohol. Traditionally recognized as dysphoric/anhedonic in nature, the dynorphin/kappa-opioid receptor (DYN/KOR) system has recently received considerable attention due to evidence suggesting that an upregulated DYN/KOR system may be a critical contributor to the complex factors that result in escalated alcohol consumption once dependent. The present review will discuss alcohol-induced plasticity in the DYN/KOR system and how these neuroadaptations could contribute to excessive alcohol seeking and consumption.http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00095/fullAmygdalaDepressionEthanolNucleus AccumbensPrefrontal Cortexdependence |
| spellingShingle | Sunil eSirohi Georgy eBakalkin Brendan M. Walker Alcohol-induced plasticity in the dynorphin / kappa-opioid receptor system Frontiers in Molecular Neuroscience Amygdala Depression Ethanol Nucleus Accumbens Prefrontal Cortex dependence |
| title | Alcohol-induced plasticity in the dynorphin / kappa-opioid receptor system |
| title_full | Alcohol-induced plasticity in the dynorphin / kappa-opioid receptor system |
| title_fullStr | Alcohol-induced plasticity in the dynorphin / kappa-opioid receptor system |
| title_full_unstemmed | Alcohol-induced plasticity in the dynorphin / kappa-opioid receptor system |
| title_short | Alcohol-induced plasticity in the dynorphin / kappa-opioid receptor system |
| title_sort | alcohol induced plasticity in the dynorphin kappa opioid receptor system |
| topic | Amygdala Depression Ethanol Nucleus Accumbens Prefrontal Cortex dependence |
| url | http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00095/full |
| work_keys_str_mv | AT sunilesirohi alcoholinducedplasticityinthedynorphinkappaopioidreceptorsystem AT georgyebakalkin alcoholinducedplasticityinthedynorphinkappaopioidreceptorsystem AT brendanmwalker alcoholinducedplasticityinthedynorphinkappaopioidreceptorsystem |