Topical Delivery of Coenzyme Q10-Loaded Microemulsion for Skin Regeneration
The aim of this study was to develop a coenzyme Q10 (CoQ10) microemulsion system with improved solubility, penetration, and wound healing efficacy. Based on the pseudo-ternary diagram, microemulsions containing isopropyl myristate (IPM), Cremophor EL<sup>®</sup>, and Transcutol<sup>...
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| Format: | Article |
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MDPI AG
2020-04-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/4/332 |
| _version_ | 1797571228147384320 |
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| author | Kyeong-A Ryu Phil June Park Seong-Bo Kim Bum-Ho Bin Dong-Jin Jang Sung Tae Kim |
| author_facet | Kyeong-A Ryu Phil June Park Seong-Bo Kim Bum-Ho Bin Dong-Jin Jang Sung Tae Kim |
| author_sort | Kyeong-A Ryu |
| collection | DOAJ |
| description | The aim of this study was to develop a coenzyme Q10 (CoQ10) microemulsion system with improved solubility, penetration, and wound healing efficacy. Based on the pseudo-ternary diagram, microemulsions containing isopropyl myristate (IPM), Cremophor EL<sup>®</sup>, and Transcutol<sup>®</sup> HP were selected and confirmed to be nanosized (<20 nm) and thermodynamically stable based on the dilution and thermodynamic stability tests. The CoQ10-loaded microemulsion with a surfactant/co-surfactant (S/CoS) ratio of 2:1 (<i>w</i>/<i>w</i> %) demonstrated a higher permeation efficacy compared to microemulsions with S/CoS ratio of 3:1 or 4:1 (<i>w</i>/<i>w</i> %). Additionally, the CoQ10-loaded microemulsion with an S/CoS ratio of 2:1 demonstrated a relatively rapid wound healing effect in keratinocytes and fibroblasts. Overall, these data suggest that a microemulsion based on IPM, Cremophor EL<sup>®</sup>, and Transcutol<sup>®</sup> HP could be an effective vehicle for the topical administration of CoQ10 and could be utilized for the application of other therapeutic agents that have difficulty in penetrating the skin. |
| first_indexed | 2024-03-10T20:37:19Z |
| format | Article |
| id | doaj.art-f167513c3a7b4a5fb91cc9ae73cc5058 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T20:37:19Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-f167513c3a7b4a5fb91cc9ae73cc50582023-11-19T20:57:53ZengMDPI AGPharmaceutics1999-49232020-04-0112433210.3390/pharmaceutics12040332Topical Delivery of Coenzyme Q10-Loaded Microemulsion for Skin RegenerationKyeong-A Ryu0Phil June Park1Seong-Bo Kim2Bum-Ho Bin3Dong-Jin Jang4Sung Tae Kim5Institute of Digital Anti-Aging Healthcare, Inje University, Gimhae 50834, KoreaDepartment of Genetic Engineering, Sungkyunkwan University, Suwon-si, Gyeonggi-do 16499, KoreaBio-Living Engineering Major, Global Leaders College, Yonsei University, 50 yonsei-ro, Shinchon-dong, Seodaemun-gu, Seoul 03722, KoreaDepartment of Biological Sciences, Ajou University, 206 Worldcup-ro, Yeongtong-gu, Suwon 16499, KoreaInstitute of Digital Anti-Aging Healthcare, Inje University, Gimhae 50834, KoreaInstitute of Digital Anti-Aging Healthcare, Inje University, Gimhae 50834, KoreaThe aim of this study was to develop a coenzyme Q10 (CoQ10) microemulsion system with improved solubility, penetration, and wound healing efficacy. Based on the pseudo-ternary diagram, microemulsions containing isopropyl myristate (IPM), Cremophor EL<sup>®</sup>, and Transcutol<sup>®</sup> HP were selected and confirmed to be nanosized (<20 nm) and thermodynamically stable based on the dilution and thermodynamic stability tests. The CoQ10-loaded microemulsion with a surfactant/co-surfactant (S/CoS) ratio of 2:1 (<i>w</i>/<i>w</i> %) demonstrated a higher permeation efficacy compared to microemulsions with S/CoS ratio of 3:1 or 4:1 (<i>w</i>/<i>w</i> %). Additionally, the CoQ10-loaded microemulsion with an S/CoS ratio of 2:1 demonstrated a relatively rapid wound healing effect in keratinocytes and fibroblasts. Overall, these data suggest that a microemulsion based on IPM, Cremophor EL<sup>®</sup>, and Transcutol<sup>®</sup> HP could be an effective vehicle for the topical administration of CoQ10 and could be utilized for the application of other therapeutic agents that have difficulty in penetrating the skin.https://www.mdpi.com/1999-4923/12/4/332coenzyme Q10microemulsiontopical administrationskin regeneration |
| spellingShingle | Kyeong-A Ryu Phil June Park Seong-Bo Kim Bum-Ho Bin Dong-Jin Jang Sung Tae Kim Topical Delivery of Coenzyme Q10-Loaded Microemulsion for Skin Regeneration Pharmaceutics coenzyme Q10 microemulsion topical administration skin regeneration |
| title | Topical Delivery of Coenzyme Q10-Loaded Microemulsion for Skin Regeneration |
| title_full | Topical Delivery of Coenzyme Q10-Loaded Microemulsion for Skin Regeneration |
| title_fullStr | Topical Delivery of Coenzyme Q10-Loaded Microemulsion for Skin Regeneration |
| title_full_unstemmed | Topical Delivery of Coenzyme Q10-Loaded Microemulsion for Skin Regeneration |
| title_short | Topical Delivery of Coenzyme Q10-Loaded Microemulsion for Skin Regeneration |
| title_sort | topical delivery of coenzyme q10 loaded microemulsion for skin regeneration |
| topic | coenzyme Q10 microemulsion topical administration skin regeneration |
| url | https://www.mdpi.com/1999-4923/12/4/332 |
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