The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice

The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice

Abstract Background C–C chemokine receptor 2 (CCR2) signaling plays a key role in pain associated with experimental murine osteoarthritis (OA) after destabilization of the medial meniscus (DMM). Here, we aimed to assess if CCR2 expressed by intra-articular sensory neurons contributes to knee hyperal...

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Bibliographic Details
Main Authors: Shingo Ishihara, Alia M. Obeidat, David L. Wokosin, Dongjun Ren, Richard J. Miller, Anne-Marie Malfait, Rachel E. Miller
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
Hyperalgesia
Sensitization
Pain
CCR2
CCL2
Online Access:https://doi.org/10.1186/s13075-021-02486-y

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