The pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity

The pathogenesis of diabetic complications: the role of DNA injury and poly(ADP-ribose) polymerase activation in peroxynitrite-mediated cytotoxicity

Recent work has demonstrated that hyperglycemia-induced overproduction of superoxide by the mitochondrial electron-transport chain triggers several pathways of injury [(protein kinase C (PKC), hexosamine and polyol pathway fluxes, advanced glycation end product formation (AGE)] involved in the patho...

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Bibliographic Details
Main Authors:	Levente Kiss, Csaba Szabó
Format:	Article
Language:	English
Published:	Fundação Oswaldo Cruz (FIOCRUZ) 2005-03-01
Series:	Memorias do Instituto Oswaldo Cruz
Subjects:	poly(ADP-ribose) polymerase peroxynitrite nitric oxide diabetic complications oxidative stress endothelial dysfunction
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900007

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