Clinical Tools for Rectal Cancer Response Assessment following Neoadjuvant Treatment in the Era of Organ Preservation
Local tumor response evaluation following neoadjuvant treatment(s) in rectal adenocarcinoma requires a multi-modality approach including physical and endoscopic evaluations, rectal protocoled MRI, and cross-sectional imaging. Clinical tumor response exists on a spectrum from complete clinical respon...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/23/5535 |
| _version_ | 1797400423785562112 |
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| author | Amalia J. Stefanou Sophie Dessureault Julian Sanchez Seth Felder |
| author_facet | Amalia J. Stefanou Sophie Dessureault Julian Sanchez Seth Felder |
| author_sort | Amalia J. Stefanou |
| collection | DOAJ |
| description | Local tumor response evaluation following neoadjuvant treatment(s) in rectal adenocarcinoma requires a multi-modality approach including physical and endoscopic evaluations, rectal protocoled MRI, and cross-sectional imaging. Clinical tumor response exists on a spectrum from complete clinical response (cCR), defined as the absence of clinical evidence of residual tumor, to near-complete response (nCR), which assumes a significant reduction in tumor burden but with increased uncertainty of residual microscopic disease, to incomplete clinical response (iCR), which incorporates all responses less than nCR that is not progressive disease. This article aims to review the clinical tools currently routinely available to evaluate treatment response and offers a potential management approach based on the extent of local tumor response. |
| first_indexed | 2024-03-09T01:54:24Z |
| format | Article |
| id | doaj.art-f1696923a36043ea9b79c70014eb6f54 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T01:54:24Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f1696923a36043ea9b79c70014eb6f542023-12-08T15:12:28ZengMDPI AGCancers2072-66942023-11-011523553510.3390/cancers15235535Clinical Tools for Rectal Cancer Response Assessment following Neoadjuvant Treatment in the Era of Organ PreservationAmalia J. Stefanou0Sophie Dessureault1Julian Sanchez2Seth Felder3Clinical and Pathologic Response to Therapy in Gastrointestinal Oncology, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL 33612, USAClinical and Pathologic Response to Therapy in Gastrointestinal Oncology, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL 33612, USAClinical and Pathologic Response to Therapy in Gastrointestinal Oncology, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL 33612, USAClinical and Pathologic Response to Therapy in Gastrointestinal Oncology, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL 33612, USALocal tumor response evaluation following neoadjuvant treatment(s) in rectal adenocarcinoma requires a multi-modality approach including physical and endoscopic evaluations, rectal protocoled MRI, and cross-sectional imaging. Clinical tumor response exists on a spectrum from complete clinical response (cCR), defined as the absence of clinical evidence of residual tumor, to near-complete response (nCR), which assumes a significant reduction in tumor burden but with increased uncertainty of residual microscopic disease, to incomplete clinical response (iCR), which incorporates all responses less than nCR that is not progressive disease. This article aims to review the clinical tools currently routinely available to evaluate treatment response and offers a potential management approach based on the extent of local tumor response.https://www.mdpi.com/2072-6694/15/23/5535rectal cancerwatch and waitnon-operative managementwait and seeorgan preservation |
| spellingShingle | Amalia J. Stefanou Sophie Dessureault Julian Sanchez Seth Felder Clinical Tools for Rectal Cancer Response Assessment following Neoadjuvant Treatment in the Era of Organ Preservation Cancers rectal cancer watch and wait non-operative management wait and see organ preservation |
| title | Clinical Tools for Rectal Cancer Response Assessment following Neoadjuvant Treatment in the Era of Organ Preservation |
| title_full | Clinical Tools for Rectal Cancer Response Assessment following Neoadjuvant Treatment in the Era of Organ Preservation |
| title_fullStr | Clinical Tools for Rectal Cancer Response Assessment following Neoadjuvant Treatment in the Era of Organ Preservation |
| title_full_unstemmed | Clinical Tools for Rectal Cancer Response Assessment following Neoadjuvant Treatment in the Era of Organ Preservation |
| title_short | Clinical Tools for Rectal Cancer Response Assessment following Neoadjuvant Treatment in the Era of Organ Preservation |
| title_sort | clinical tools for rectal cancer response assessment following neoadjuvant treatment in the era of organ preservation |
| topic | rectal cancer watch and wait non-operative management wait and see organ preservation |
| url | https://www.mdpi.com/2072-6694/15/23/5535 |
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