Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly
In the context of the global COVID-19 pandemic, the phenomenon that the elderly have higher morbidity and mortality is of great concern. Existing evidence suggests that senescence and viral infection interact with each other. Viral infection can lead to the aggravation of senescence through multiple...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1098712/full |
| _version_ | 1797857456961880064 |
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| author | Zhiqiang Li Mingfu Tian Guolei Wang Xianghua Cui Jun’e Ma Siyu Liu Bingzheng Shen Fang Liu Kailang Wu Xuan Xiao Chengliang Zhu |
| author_facet | Zhiqiang Li Mingfu Tian Guolei Wang Xianghua Cui Jun’e Ma Siyu Liu Bingzheng Shen Fang Liu Kailang Wu Xuan Xiao Chengliang Zhu |
| author_sort | Zhiqiang Li |
| collection | DOAJ |
| description | In the context of the global COVID-19 pandemic, the phenomenon that the elderly have higher morbidity and mortality is of great concern. Existing evidence suggests that senescence and viral infection interact with each other. Viral infection can lead to the aggravation of senescence through multiple pathways, while virus-induced senescence combined with existing senescence in the elderly aggravates the severity of viral infections and promotes excessive age-related inflammation and multiple organ damage or dysfunction, ultimately resulting in higher mortality. The underlying mechanisms may involve mitochondrial dysfunction, abnormal activation of the cGAS-STING pathway and NLRP3 inflammasome, the role of pre-activated macrophages and over-recruited immune cells, and accumulation of immune cells with trained immunity. Thus, senescence-targeted drugs were shown to have positive effects on the treatment of viral infectious diseases in the elderly, which has received great attention and extensive research. Therefore, this review focused on the relationship between senescence and viral infection, as well as the significance of senotherapeutics for the treatment of viral infectious diseases. |
| first_indexed | 2024-04-09T20:57:00Z |
| format | Article |
| id | doaj.art-f16a36a628224ce181aed1501d2b9cdf |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-09T20:57:00Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-f16a36a628224ce181aed1501d2b9cdf2023-03-29T16:04:55ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-03-011310.3389/fcimb.2023.10987121098712Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderlyZhiqiang Li0Mingfu Tian1Guolei Wang2Xianghua Cui3Jun’e Ma4Siyu Liu5Bingzheng Shen6Fang Liu7Kailang Wu8Xuan Xiao9Chengliang Zhu10Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, ChinaState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, ChinaDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, ChinaState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, ChinaDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, ChinaState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, ChinaState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, ChinaDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, ChinaIn the context of the global COVID-19 pandemic, the phenomenon that the elderly have higher morbidity and mortality is of great concern. Existing evidence suggests that senescence and viral infection interact with each other. Viral infection can lead to the aggravation of senescence through multiple pathways, while virus-induced senescence combined with existing senescence in the elderly aggravates the severity of viral infections and promotes excessive age-related inflammation and multiple organ damage or dysfunction, ultimately resulting in higher mortality. The underlying mechanisms may involve mitochondrial dysfunction, abnormal activation of the cGAS-STING pathway and NLRP3 inflammasome, the role of pre-activated macrophages and over-recruited immune cells, and accumulation of immune cells with trained immunity. Thus, senescence-targeted drugs were shown to have positive effects on the treatment of viral infectious diseases in the elderly, which has received great attention and extensive research. Therefore, this review focused on the relationship between senescence and viral infection, as well as the significance of senotherapeutics for the treatment of viral infectious diseases.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1098712/fullsenescencevirusCOVID-19cGAS-STINGNLRP3 inflammasomesenotherapeutics |
| spellingShingle | Zhiqiang Li Mingfu Tian Guolei Wang Xianghua Cui Jun’e Ma Siyu Liu Bingzheng Shen Fang Liu Kailang Wu Xuan Xiao Chengliang Zhu Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly Frontiers in Cellular and Infection Microbiology senescence virus COVID-19 cGAS-STING NLRP3 inflammasome senotherapeutics |
| title | Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly |
| title_full | Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly |
| title_fullStr | Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly |
| title_full_unstemmed | Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly |
| title_short | Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly |
| title_sort | senotherapeutics an emerging approach to the treatment of viral infectious diseases in the elderly |
| topic | senescence virus COVID-19 cGAS-STING NLRP3 inflammasome senotherapeutics |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1098712/full |
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