Towards a data-integrated cell
Integration of omics data remains a challenge. Here, the authors introduce iCell, a framework to integrate tissue-specific protein–protein interaction, co-expression and genetic interaction data, enabling identification of the most rewired genes in cancer, unidentifiable in individual data layers.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08797-8 |
| _version_ | 1818992797310517248 |
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| author | Noël Malod-Dognin Julia Petschnigg Sam F. L. Windels Janez Povh Harry Hemingway Robin Ketteler Nataša Pržulj |
| author_facet | Noël Malod-Dognin Julia Petschnigg Sam F. L. Windels Janez Povh Harry Hemingway Robin Ketteler Nataša Pržulj |
| author_sort | Noël Malod-Dognin |
| collection | DOAJ |
| description | Integration of omics data remains a challenge. Here, the authors introduce iCell, a framework to integrate tissue-specific protein–protein interaction, co-expression and genetic interaction data, enabling identification of the most rewired genes in cancer, unidentifiable in individual data layers. |
| first_indexed | 2024-12-20T20:31:52Z |
| format | Article |
| id | doaj.art-f16ba5ea82984765ad79c0f292ce025e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:31:52Z |
| publishDate | 2019-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f16ba5ea82984765ad79c0f292ce025e2022-12-21T19:27:20ZengNature PortfolioNature Communications2041-17232019-02-0110111310.1038/s41467-019-08797-8Towards a data-integrated cellNoël Malod-Dognin0Julia Petschnigg1Sam F. L. Windels2Janez Povh3Harry Hemingway4Robin Ketteler5Nataša Pržulj6Department of Computer Science, University College LondonDepartment of Computer Science, University College LondonDepartment of Computer Science, University College LondonFaculty of Mechanical Engineering, University of LjubljanaHealth Data Research UK London, University College LondonMRC Laboratory for Molecular Cell Biology, University College LondonDepartment of Computer Science, University College LondonIntegration of omics data remains a challenge. Here, the authors introduce iCell, a framework to integrate tissue-specific protein–protein interaction, co-expression and genetic interaction data, enabling identification of the most rewired genes in cancer, unidentifiable in individual data layers.https://doi.org/10.1038/s41467-019-08797-8 |
| spellingShingle | Noël Malod-Dognin Julia Petschnigg Sam F. L. Windels Janez Povh Harry Hemingway Robin Ketteler Nataša Pržulj Towards a data-integrated cell Nature Communications |
| title | Towards a data-integrated cell |
| title_full | Towards a data-integrated cell |
| title_fullStr | Towards a data-integrated cell |
| title_full_unstemmed | Towards a data-integrated cell |
| title_short | Towards a data-integrated cell |
| title_sort | towards a data integrated cell |
| url | https://doi.org/10.1038/s41467-019-08797-8 |
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