The ubiquitin ligase HECTD1 promotes retinoic acid signaling required for development of the aortic arch

The ubiquitin ligase HECTD1 promotes retinoic acid signaling required for development of the aortic arch

The development of the aortic arch is a complex process that involves remodeling of the bilaterally symmetrical pharyngeal arch arteries (PAAs) into the mature asymmetric aortic arch. Retinoic acid signaling is a key regulator of this process by directing patterning of the second heart field (SHF),...

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Bibliographic Details
Main Authors: Kelsey F. Sugrue, Anjali A. Sarkar, Linda Leatherbury, Irene E. Zohn
Format: Article
Language:English
Published: The Company of Biologists 2019-01-01
Series:Disease Models & Mechanisms
Subjects:
Congenital heart defects
Hectd1
Retinoic acid
Vitamin A deficiency
Aortic arch development
Online Access:http://dmm.biologists.org/content/12/1/dmm036491

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