Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications
Since fluoro-compounds are popular in industrial settings, efficient methods for incorporation of fluoride into organic molecules are desirable. Here, the authors developed trifluoroacetaldehyde N-tfsylhydrazone (TFHZ-Tfs) as a CF3CHN2 surrogate that generates CF3CHN2 in situ under basic conditions.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-08253-z |
| _version_ | 1818977765540495360 |
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| author | Xinyu Zhang Zhaohong Liu Xiangyu Yang Yuanqing Dong Matteo Virelli Giuseppe Zanoni Edward A. Anderson Xihe Bi |
| author_facet | Xinyu Zhang Zhaohong Liu Xiangyu Yang Yuanqing Dong Matteo Virelli Giuseppe Zanoni Edward A. Anderson Xihe Bi |
| author_sort | Xinyu Zhang |
| collection | DOAJ |
| description | Since fluoro-compounds are popular in industrial settings, efficient methods for incorporation of fluoride into organic molecules are desirable. Here, the authors developed trifluoroacetaldehyde N-tfsylhydrazone (TFHZ-Tfs) as a CF3CHN2 surrogate that generates CF3CHN2 in situ under basic conditions. |
| first_indexed | 2024-12-20T16:32:57Z |
| format | Article |
| id | doaj.art-f16d80073b9e4ad596a828624a933cc7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:32:57Z |
| publishDate | 2019-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f16d80073b9e4ad596a828624a933cc72022-12-21T19:33:14ZengNature PortfolioNature Communications2041-17232019-01-011011910.1038/s41467-018-08253-zUse of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applicationsXinyu Zhang0Zhaohong Liu1Xiangyu Yang2Yuanqing Dong3Matteo Virelli4Giuseppe Zanoni5Edward A. Anderson6Xihe Bi7Department of Chemistry, Northeast Normal UniversityDepartment of Chemistry, Northeast Normal UniversityDepartment of Chemistry, Northeast Normal UniversityDepartment of Chemistry, Northeast Normal UniversityDepartment of Chemistry, University of PaviaDepartment of Chemistry, University of PaviaChemistry Research Laboratory, University of OxfordDepartment of Chemistry, Northeast Normal UniversitySince fluoro-compounds are popular in industrial settings, efficient methods for incorporation of fluoride into organic molecules are desirable. Here, the authors developed trifluoroacetaldehyde N-tfsylhydrazone (TFHZ-Tfs) as a CF3CHN2 surrogate that generates CF3CHN2 in situ under basic conditions.https://doi.org/10.1038/s41467-018-08253-z |
| spellingShingle | Xinyu Zhang Zhaohong Liu Xiangyu Yang Yuanqing Dong Matteo Virelli Giuseppe Zanoni Edward A. Anderson Xihe Bi Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications Nature Communications |
| title | Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications |
| title_full | Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications |
| title_fullStr | Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications |
| title_full_unstemmed | Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications |
| title_short | Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications |
| title_sort | use of trifluoroacetaldehyde n tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications |
| url | https://doi.org/10.1038/s41467-018-08253-z |
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