Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units

Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units

Abstract Background Late-phase platform protocols (including basket, umbrella, multi-arm multi-stage (MAMS), and master protocols) are generally agreed to be more efficient than traditional two-arm clinical trial designs but are not extensively used. We have gathered the experience of running a numb...

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Bibliographic Details
Main Authors: Sharon B. Love, Fay Cafferty, Claire Snowdon, Karen Carty, Joshua Savage, Philip Pallmann, Lucy McParland, Louise Brown, Lindsey Masters, Francesca Schiavone, Dominic Hague, Stephen Townsend, Claire Amos, Annabelle South, Kate Sturgeon, Ruth Langley, Timothy Maughan, Nicholas James, Emma Hall, Sarah Kernaghan, Judith Bliss, Nick Turner, Andrew Tutt, Christina Yap, Charlotte Firth, Anthony Kong, Hisham Mehanna, Colin Watts, Robert Hills, Ian Thomas, Mhairi Copland, Sue Bell, David Sebag-Montefiore, Robert Jones, Mahesh K. B. Parmar, Matthew R. Sydes
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Trials
Subjects:
Platform protocols
Trial conduct
Multi-arm multi-stage trials
Umbrella trials
Basket trials
Stratified medicine
Online Access:https://doi.org/10.1186/s13063-022-06680-4

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