Widespread and Long-Enduring Hyperkeratosis Lenticularis Perstans (Flegel’s Disease): Clinico-Pathological and Dermoscopic Features of a Rare Presentation
Hyperkeratosis lenticularis perstans, also known as Flegel’s disease (FD), is a rare cutaneous disorder affecting mainly the lower extremities of middle-aged people. Due to its rarity, this disease is usually not recognized by physicians resulting in a delay in diagnosis, especially in those cases w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Dermatopathology |
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| Online Access: | https://www.mdpi.com/2296-3529/10/1/6 |
| _version_ | 1797612447022972928 |
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| author | Giorgio Stabile Giovanni Paolino Nathalie Rizzo Franco Rongioletti |
| author_facet | Giorgio Stabile Giovanni Paolino Nathalie Rizzo Franco Rongioletti |
| author_sort | Giorgio Stabile |
| collection | DOAJ |
| description | Hyperkeratosis lenticularis perstans, also known as Flegel’s disease (FD), is a rare cutaneous disorder affecting mainly the lower extremities of middle-aged people. Due to its rarity, this disease is usually not recognized by physicians resulting in a delay in diagnosis, especially in those cases with atypical cutaneous involvement. Herein, we present a 72-year-old woman who developed FD characterized by a generalized distribution, involving, in addition to the lower limbs, the trunk and the upper limbs as well. We performed a description of the dermoscopic and pathologic features of this rare entity, also carrying out a brief reappraisal of the cases of FD with a diffuse, atypical and generalized distribution that have been described in the literature. Histopathology with clinical correlation is the cornerstone of the diagnosis, even and especially in atypical cases. This patient with a disease duration of 58 years also represents the longest-lasting case of FD reported in the literature. |
| first_indexed | 2024-03-11T06:42:20Z |
| format | Article |
| id | doaj.art-f16f7c3e0b2e46bb8f1570d344dbaffb |
| institution | Directory Open Access Journal |
| issn | 2296-3529 |
| language | English |
| last_indexed | 2024-03-11T06:42:20Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dermatopathology |
| spelling | doaj.art-f16f7c3e0b2e46bb8f1570d344dbaffb2023-11-17T10:32:41ZengMDPI AGDermatopathology2296-35292023-01-01101465110.3390/dermatopathology10010006Widespread and Long-Enduring Hyperkeratosis Lenticularis Perstans (Flegel’s Disease): Clinico-Pathological and Dermoscopic Features of a Rare PresentationGiorgio Stabile0Giovanni Paolino1Nathalie Rizzo2Franco Rongioletti3Dermatologia Clinica, Università Vita-Salute San Raffaele, 20132 Milan, ItalyDermatologia Clinica, Università Vita-Salute San Raffaele, 20132 Milan, ItalySurgical Pathology, IRCCS Ospedale San Raffaele, 20132 Milan, ItalyDermatologia Clinica, Università Vita-Salute San Raffaele, 20132 Milan, ItalyHyperkeratosis lenticularis perstans, also known as Flegel’s disease (FD), is a rare cutaneous disorder affecting mainly the lower extremities of middle-aged people. Due to its rarity, this disease is usually not recognized by physicians resulting in a delay in diagnosis, especially in those cases with atypical cutaneous involvement. Herein, we present a 72-year-old woman who developed FD characterized by a generalized distribution, involving, in addition to the lower limbs, the trunk and the upper limbs as well. We performed a description of the dermoscopic and pathologic features of this rare entity, also carrying out a brief reappraisal of the cases of FD with a diffuse, atypical and generalized distribution that have been described in the literature. Histopathology with clinical correlation is the cornerstone of the diagnosis, even and especially in atypical cases. This patient with a disease duration of 58 years also represents the longest-lasting case of FD reported in the literature.https://www.mdpi.com/2296-3529/10/1/6hyperkeratosis lenticularis perstansFlegel’s diseasehistopathologydermoscopy |
| spellingShingle | Giorgio Stabile Giovanni Paolino Nathalie Rizzo Franco Rongioletti Widespread and Long-Enduring Hyperkeratosis Lenticularis Perstans (Flegel’s Disease): Clinico-Pathological and Dermoscopic Features of a Rare Presentation Dermatopathology hyperkeratosis lenticularis perstans Flegel’s disease histopathology dermoscopy |
| title | Widespread and Long-Enduring Hyperkeratosis Lenticularis Perstans (Flegel’s Disease): Clinico-Pathological and Dermoscopic Features of a Rare Presentation |
| title_full | Widespread and Long-Enduring Hyperkeratosis Lenticularis Perstans (Flegel’s Disease): Clinico-Pathological and Dermoscopic Features of a Rare Presentation |
| title_fullStr | Widespread and Long-Enduring Hyperkeratosis Lenticularis Perstans (Flegel’s Disease): Clinico-Pathological and Dermoscopic Features of a Rare Presentation |
| title_full_unstemmed | Widespread and Long-Enduring Hyperkeratosis Lenticularis Perstans (Flegel’s Disease): Clinico-Pathological and Dermoscopic Features of a Rare Presentation |
| title_short | Widespread and Long-Enduring Hyperkeratosis Lenticularis Perstans (Flegel’s Disease): Clinico-Pathological and Dermoscopic Features of a Rare Presentation |
| title_sort | widespread and long enduring hyperkeratosis lenticularis perstans flegel s disease clinico pathological and dermoscopic features of a rare presentation |
| topic | hyperkeratosis lenticularis perstans Flegel’s disease histopathology dermoscopy |
| url | https://www.mdpi.com/2296-3529/10/1/6 |
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