The awesome lysosome
In the early 50s, Christian De Duve identified a new cellular structure, the lysosome, defined as the cell's “suicide bag” (de Duve, ). Sixty years later, it is clear that the lysosome greatly exceeded the expectations of its discoverer. Over 50 different types of lysosomal storage diseases hav...
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| Format: | Article |
| Language: | English |
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Springer Nature
2016-02-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.201505966 |
| _version_ | 1797225455431974912 |
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| author | Andrea Ballabio |
| author_facet | Andrea Ballabio |
| author_sort | Andrea Ballabio |
| collection | DOAJ |
| description | In the early 50s, Christian De Duve identified a new cellular structure, the lysosome, defined as the cell's “suicide bag” (de Duve, ). Sixty years later, it is clear that the lysosome greatly exceeded the expectations of its discoverer. Over 50 different types of lysosomal storage diseases have been identified, each due to the deficiency or malfunction of a specific lysosomal protein. In addition, an important role of the lysosome has been unveiled in several common human diseases, such as cancer, obesity, neurodegenerative diseases, and infection. Recent studies have led to the identification of a lysosome‐to‐nucleus signaling pathway and a lysosomal gene network that regulate cellular clearance and energy metabolism. These observations have opened a completely new field of research and changed our traditional view of the lysosome from a dead‐end organelle to a control center of cell metabolism. An important challenge for the future will be to exploit these discoveries to identify modulators of lysosomal function that may be used to treat human diseases. |
| first_indexed | 2024-03-13T03:12:25Z |
| format | Article |
| id | doaj.art-f1703c6011a946f3a5f227d32d9d21c9 |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2024-04-24T14:09:17Z |
| publishDate | 2016-02-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-f1703c6011a946f3a5f227d32d9d21c92024-04-03T09:38:20ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842016-02-0182737610.15252/emmm.201505966The awesome lysosomeAndrea Ballabio0Telethon Institute of Genetics and Medicine (TIGEM) Naples ItalyIn the early 50s, Christian De Duve identified a new cellular structure, the lysosome, defined as the cell's “suicide bag” (de Duve, ). Sixty years later, it is clear that the lysosome greatly exceeded the expectations of its discoverer. Over 50 different types of lysosomal storage diseases have been identified, each due to the deficiency or malfunction of a specific lysosomal protein. In addition, an important role of the lysosome has been unveiled in several common human diseases, such as cancer, obesity, neurodegenerative diseases, and infection. Recent studies have led to the identification of a lysosome‐to‐nucleus signaling pathway and a lysosomal gene network that regulate cellular clearance and energy metabolism. These observations have opened a completely new field of research and changed our traditional view of the lysosome from a dead‐end organelle to a control center of cell metabolism. An important challenge for the future will be to exploit these discoveries to identify modulators of lysosomal function that may be used to treat human diseases.https://doi.org/10.15252/emmm.201505966 |
| spellingShingle | Andrea Ballabio The awesome lysosome EMBO Molecular Medicine |
| title | The awesome lysosome |
| title_full | The awesome lysosome |
| title_fullStr | The awesome lysosome |
| title_full_unstemmed | The awesome lysosome |
| title_short | The awesome lysosome |
| title_sort | awesome lysosome |
| url | https://doi.org/10.15252/emmm.201505966 |
| work_keys_str_mv | AT andreaballabio theawesomelysosome AT andreaballabio awesomelysosome |