Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy
Cellular senescence (CS) is a major homeostatic biological process, which plays a key role in normal tissue development and provides protection from stressful cell insults. The role of CS in mammary-gland development and breast cancer is not well understood. While there is a lack of experimental dat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/6/994 |
| _version_ | 1797487138490548224 |
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| author | Chaido Sirinian Stavros Peroukidis Katharina Kriegsmann Dimitrios Chaniotis Angelos Koutras Mark Kriegsmann Anastasios D. Papanastasiou |
| author_facet | Chaido Sirinian Stavros Peroukidis Katharina Kriegsmann Dimitrios Chaniotis Angelos Koutras Mark Kriegsmann Anastasios D. Papanastasiou |
| author_sort | Chaido Sirinian |
| collection | DOAJ |
| description | Cellular senescence (CS) is a major homeostatic biological process, which plays a key role in normal tissue development and provides protection from stressful cell insults. The role of CS in mammary-gland development and breast cancer is not well understood. While there is a lack of experimental data on the role of CS in the development of the pre-pubertal mammary gland, there is evidence for a biphasic senescence response in adult normal-mammary-epithelial cells, where the bypass of the first senescence barrier (M0) seems to be a key step in the development of premalignant lesions, with genetic abnormalities that resemble in situ breast carcinoma. Further, there is accumulating evidence for the role of cellular senescence in breast-cancer response, regarding treatment and patient outcome. Here, we review the current literature on cellular senescence, in epithelial-mammary cells, breast-cancer cells, and breast-tumor-microenvironment-resident cells. Furthermore, we discuss its putative role in breast-cancer response, regarding treatment and disease progression. In addition, we provide preliminary evidence of CS in breast-cancer-microenvironment cells, such as tumor-associated fibroblasts and tumor-infiltrating lymphocytes, by employing the novel GL13 lipofuscin stain, as a marker of cellular senescence. |
| first_indexed | 2024-03-09T23:44:20Z |
| format | Article |
| id | doaj.art-f170bdd4c1544a408607960e9a9b9edb |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T23:44:20Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-f170bdd4c1544a408607960e9a9b9edb2023-11-23T16:47:32ZengMDPI AGGenes2073-44252022-06-0113699410.3390/genes13060994Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer TherapyChaido Sirinian0Stavros Peroukidis1Katharina Kriegsmann2Dimitrios Chaniotis3Angelos Koutras4Mark Kriegsmann5Anastasios D. Papanastasiou6Molecular Oncology Laboratory, Department of Medicine, Division of Oncology, University of Patras, 265 04 Patras, GreecePanarkadikon General Hospital, 221 00 Tripolis, GreeceDepartment of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, 69120 Heidelberg, GermanyDepartment of Biomedical Sciences, University of West Attica, 122 43 Athens, GreeceMolecular Oncology Laboratory, Department of Medicine, Division of Oncology, University of Patras, 265 04 Patras, GreeceInstitute of Pathology, University of Heidelberg, 69117 Heidelberg, GermanyDepartment of Biomedical Sciences, University of West Attica, 122 43 Athens, GreeceCellular senescence (CS) is a major homeostatic biological process, which plays a key role in normal tissue development and provides protection from stressful cell insults. The role of CS in mammary-gland development and breast cancer is not well understood. While there is a lack of experimental data on the role of CS in the development of the pre-pubertal mammary gland, there is evidence for a biphasic senescence response in adult normal-mammary-epithelial cells, where the bypass of the first senescence barrier (M0) seems to be a key step in the development of premalignant lesions, with genetic abnormalities that resemble in situ breast carcinoma. Further, there is accumulating evidence for the role of cellular senescence in breast-cancer response, regarding treatment and patient outcome. Here, we review the current literature on cellular senescence, in epithelial-mammary cells, breast-cancer cells, and breast-tumor-microenvironment-resident cells. Furthermore, we discuss its putative role in breast-cancer response, regarding treatment and disease progression. In addition, we provide preliminary evidence of CS in breast-cancer-microenvironment cells, such as tumor-associated fibroblasts and tumor-infiltrating lymphocytes, by employing the novel GL13 lipofuscin stain, as a marker of cellular senescence.https://www.mdpi.com/2073-4425/13/6/994mammary glandbreast cancercellular senescencechemotherapyIHCGL13 |
| spellingShingle | Chaido Sirinian Stavros Peroukidis Katharina Kriegsmann Dimitrios Chaniotis Angelos Koutras Mark Kriegsmann Anastasios D. Papanastasiou Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy Genes mammary gland breast cancer cellular senescence chemotherapy IHC GL13 |
| title | Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy |
| title_full | Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy |
| title_fullStr | Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy |
| title_full_unstemmed | Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy |
| title_short | Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy |
| title_sort | cellular senescence in normal mammary gland and breast cancer implications for cancer therapy |
| topic | mammary gland breast cancer cellular senescence chemotherapy IHC GL13 |
| url | https://www.mdpi.com/2073-4425/13/6/994 |
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