Single-sided magnetic resonance-based sensor for point-of-care evaluation of muscle
Abstract Magnetic resonance imaging is a widespread clinical tool for the detection of soft tissue morphology and pathology. However, the clinical deployment of magnetic resonance imaging scanners is ultimately limited by size, cost, and space constraints. Here, we discuss the design and performance...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-44561-9 |
| _version_ | 1827382100755480576 |
|---|---|
| author | Sydney E. Sherman Alexa S. Zammit Won-Seok Heo Matthew S. Rosen Michael J. Cima |
| author_facet | Sydney E. Sherman Alexa S. Zammit Won-Seok Heo Matthew S. Rosen Michael J. Cima |
| author_sort | Sydney E. Sherman |
| collection | DOAJ |
| description | Abstract Magnetic resonance imaging is a widespread clinical tool for the detection of soft tissue morphology and pathology. However, the clinical deployment of magnetic resonance imaging scanners is ultimately limited by size, cost, and space constraints. Here, we discuss the design and performance of a low-field single-sided magnetic resonance sensor intended for point-of-care evaluation of skeletal muscle in vivo. The 11 kg sensor has a penetration depth of >8 mm, which allows for an accurate analysis of muscle tissue and can avoid signal from more proximal layers, including subcutaneous adipose tissue. Low operational power and shielding requirements are achieved through the design of a permanent magnet array and surface transceiver coil. The sensor can acquire high signal-to-noise measurements in minutes, making it practical as a point-of-care tool for many quantitative diagnostic measurements, including T2 relaxometry. In this work, we present the in vitro and human in vivo performance of the device for muscle tissue evaluation. |
| first_indexed | 2024-03-08T14:14:39Z |
| format | Article |
| id | doaj.art-f171e93623634d2bbe344f230d799f39 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-08T14:14:39Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f171e93623634d2bbe344f230d799f392024-01-14T12:29:40ZengNature PortfolioNature Communications2041-17232024-01-011511910.1038/s41467-023-44561-9Single-sided magnetic resonance-based sensor for point-of-care evaluation of muscleSydney E. Sherman0Alexa S. Zammit1Won-Seok Heo2Matthew S. Rosen3Michael J. Cima4Harvard-MIT Program in Health Science and Technology, Massachusetts Institute of TechnologyKoch Institute for Integrative Cancer Research, Massachusetts Institute of TechnologyKoch Institute for Integrative Cancer Research, Massachusetts Institute of TechnologyDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General HospitalKoch Institute for Integrative Cancer Research, Massachusetts Institute of TechnologyAbstract Magnetic resonance imaging is a widespread clinical tool for the detection of soft tissue morphology and pathology. However, the clinical deployment of magnetic resonance imaging scanners is ultimately limited by size, cost, and space constraints. Here, we discuss the design and performance of a low-field single-sided magnetic resonance sensor intended for point-of-care evaluation of skeletal muscle in vivo. The 11 kg sensor has a penetration depth of >8 mm, which allows for an accurate analysis of muscle tissue and can avoid signal from more proximal layers, including subcutaneous adipose tissue. Low operational power and shielding requirements are achieved through the design of a permanent magnet array and surface transceiver coil. The sensor can acquire high signal-to-noise measurements in minutes, making it practical as a point-of-care tool for many quantitative diagnostic measurements, including T2 relaxometry. In this work, we present the in vitro and human in vivo performance of the device for muscle tissue evaluation.https://doi.org/10.1038/s41467-023-44561-9 |
| spellingShingle | Sydney E. Sherman Alexa S. Zammit Won-Seok Heo Matthew S. Rosen Michael J. Cima Single-sided magnetic resonance-based sensor for point-of-care evaluation of muscle Nature Communications |
| title | Single-sided magnetic resonance-based sensor for point-of-care evaluation of muscle |
| title_full | Single-sided magnetic resonance-based sensor for point-of-care evaluation of muscle |
| title_fullStr | Single-sided magnetic resonance-based sensor for point-of-care evaluation of muscle |
| title_full_unstemmed | Single-sided magnetic resonance-based sensor for point-of-care evaluation of muscle |
| title_short | Single-sided magnetic resonance-based sensor for point-of-care evaluation of muscle |
| title_sort | single sided magnetic resonance based sensor for point of care evaluation of muscle |
| url | https://doi.org/10.1038/s41467-023-44561-9 |
| work_keys_str_mv | AT sydneyesherman singlesidedmagneticresonancebasedsensorforpointofcareevaluationofmuscle AT alexaszammit singlesidedmagneticresonancebasedsensorforpointofcareevaluationofmuscle AT wonseokheo singlesidedmagneticresonancebasedsensorforpointofcareevaluationofmuscle AT matthewsrosen singlesidedmagneticresonancebasedsensorforpointofcareevaluationofmuscle AT michaeljcima singlesidedmagneticresonancebasedsensorforpointofcareevaluationofmuscle |