The Immunomodulatory Effects of Mesenchymal Stem Cells on Regulatory B Cells
The therapeutic potential of mesenchymal stem cells (MSCs) has been investigated in many preclinical and clinical studies. This potential is dominantly based on the immunosuppressive properties of MSCs. Although the therapeutic profiles of MSC transplantation are still not fully characterized, accum...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01843/full |
| _version_ | 1828760267656265728 |
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| author | Jialing Liu Qiuli Liu Xiaoyong Chen Xiaoyong Chen Xiaoyong Chen |
| author_facet | Jialing Liu Qiuli Liu Xiaoyong Chen Xiaoyong Chen Xiaoyong Chen |
| author_sort | Jialing Liu |
| collection | DOAJ |
| description | The therapeutic potential of mesenchymal stem cells (MSCs) has been investigated in many preclinical and clinical studies. This potential is dominantly based on the immunosuppressive properties of MSCs. Although the therapeutic profiles of MSC transplantation are still not fully characterized, accumulating evidence has revealed that B cells change after MSC infusion, in particular inducing regulatory B cells (Bregs). The immunosuppressive effects of Bregs have been demonstrated, and these cells are being evaluated as new targets for the treatment of inflammatory diseases. MSCs are capable of educating B cells and inducing regulatory B cell production via cell-to-cell contact, soluble factors, and extracellular vesicles (EVs). These cells thus have the potential to complement each other's immunomodulatory functions, and a combined approach may enable synergistic effects for the treatment of immunological diseases. However, compared with investigations regarding other immune cells, investigations into how MSCs specifically regulate Bregs have been superficial and insufficient. In this review, we discuss the current findings related to the immunomodulatory effects of MSCs on regulatory B cells and provide optimal strategies for applications in immune-related disease treatments. |
| first_indexed | 2024-12-11T01:11:13Z |
| format | Article |
| id | doaj.art-f1728095136f4d39aa6a6e026bd9e739 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T01:11:13Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f1728095136f4d39aa6a6e026bd9e7392022-12-22T01:26:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-08-011110.3389/fimmu.2020.01843551680The Immunomodulatory Effects of Mesenchymal Stem Cells on Regulatory B CellsJialing Liu0Qiuli Liu1Xiaoyong Chen2Xiaoyong Chen3Xiaoyong Chen4The Biotherapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaThe Biotherapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaThe Biotherapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, ChinaDepartment of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, ChinaThe therapeutic potential of mesenchymal stem cells (MSCs) has been investigated in many preclinical and clinical studies. This potential is dominantly based on the immunosuppressive properties of MSCs. Although the therapeutic profiles of MSC transplantation are still not fully characterized, accumulating evidence has revealed that B cells change after MSC infusion, in particular inducing regulatory B cells (Bregs). The immunosuppressive effects of Bregs have been demonstrated, and these cells are being evaluated as new targets for the treatment of inflammatory diseases. MSCs are capable of educating B cells and inducing regulatory B cell production via cell-to-cell contact, soluble factors, and extracellular vesicles (EVs). These cells thus have the potential to complement each other's immunomodulatory functions, and a combined approach may enable synergistic effects for the treatment of immunological diseases. However, compared with investigations regarding other immune cells, investigations into how MSCs specifically regulate Bregs have been superficial and insufficient. In this review, we discuss the current findings related to the immunomodulatory effects of MSCs on regulatory B cells and provide optimal strategies for applications in immune-related disease treatments.https://www.frontiersin.org/article/10.3389/fimmu.2020.01843/fullmesenchymal stem cells (MSCs)regulatory B cells (Bregs)cell-to-cell contactsoluble factorsextracellular vesicles (EVs) |
| spellingShingle | Jialing Liu Qiuli Liu Xiaoyong Chen Xiaoyong Chen Xiaoyong Chen The Immunomodulatory Effects of Mesenchymal Stem Cells on Regulatory B Cells Frontiers in Immunology mesenchymal stem cells (MSCs) regulatory B cells (Bregs) cell-to-cell contact soluble factors extracellular vesicles (EVs) |
| title | The Immunomodulatory Effects of Mesenchymal Stem Cells on Regulatory B Cells |
| title_full | The Immunomodulatory Effects of Mesenchymal Stem Cells on Regulatory B Cells |
| title_fullStr | The Immunomodulatory Effects of Mesenchymal Stem Cells on Regulatory B Cells |
| title_full_unstemmed | The Immunomodulatory Effects of Mesenchymal Stem Cells on Regulatory B Cells |
| title_short | The Immunomodulatory Effects of Mesenchymal Stem Cells on Regulatory B Cells |
| title_sort | immunomodulatory effects of mesenchymal stem cells on regulatory b cells |
| topic | mesenchymal stem cells (MSCs) regulatory B cells (Bregs) cell-to-cell contact soluble factors extracellular vesicles (EVs) |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.01843/full |
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