h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy
Ih tunes hippocampal CA1 pyramidal cell dendrites to optimally respond to theta inputs (4–12 Hz), and provides a negative time delay to theta inputs. Decreased Ih activity, as seen in experimental temporal lobe epilepsy (TLE), could significantly alter the response of dendrites to theta inputs. Here...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2009-03-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S096999610800301X |
| _version_ | 1818647926313844736 |
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| author | Béatrice Marcelin Laëtitia Chauvière Albert Becker Michele Migliore Monique Esclapez Christophe Bernard |
| author_facet | Béatrice Marcelin Laëtitia Chauvière Albert Becker Michele Migliore Monique Esclapez Christophe Bernard |
| author_sort | Béatrice Marcelin |
| collection | DOAJ |
| description | Ih tunes hippocampal CA1 pyramidal cell dendrites to optimally respond to theta inputs (4–12 Hz), and provides a negative time delay to theta inputs. Decreased Ih activity, as seen in experimental temporal lobe epilepsy (TLE), could significantly alter the response of dendrites to theta inputs. Here we report a progressive erosion of theta resonance and phase lead in pyramidal cell dendrites during epileptogenesis in a rat model of TLE. These alterations were due to decreased Ih availability, via a decline in HCN1/HCN2 subunit expression resulting in decreased h currents, and altered kinetics of the residual channels. This acquired HCN channelopathy thus compromises temporal coding and tuning to theta inputs in pyramidal cell dendrites. Decreased theta resonance in vitro also correlated with a reduction in theta frequency and power in vivo. We suggest that the neuronal/circuitry changes associated with TLE, including altered Ih-dependent inductive mechanisms, can disrupt hippocampal theta function. |
| first_indexed | 2024-12-17T01:10:17Z |
| format | Article |
| id | doaj.art-f1728781d2df4392bfc6b71ad7d0b0ea |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-17T01:10:17Z |
| publishDate | 2009-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-f1728781d2df4392bfc6b71ad7d0b0ea2022-12-21T22:09:09ZengElsevierNeurobiology of Disease1095-953X2009-03-01333436447h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsyBéatrice Marcelin0Laëtitia Chauvière1Albert Becker2Michele Migliore3Monique Esclapez4Christophe Bernard5INSERM-U751, Université de la Méditerranée, 27, Bd Jean Moulin, 13005 Marseille, FranceINSERM-U751, Université de la Méditerranée, 27, Bd Jean Moulin, 13005 Marseille, FranceDepartment of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, GermanyInstitute of Biophysics, National Research Council, Palermo, ItalyINSERM-U751, Université de la Méditerranée, 27, Bd Jean Moulin, 13005 Marseille, FranceINSERM-U751, Université de la Méditerranée, 27, Bd Jean Moulin, 13005 Marseille, France; Corresponding author. Fax: +33 4 91 78 99 14.Ih tunes hippocampal CA1 pyramidal cell dendrites to optimally respond to theta inputs (4–12 Hz), and provides a negative time delay to theta inputs. Decreased Ih activity, as seen in experimental temporal lobe epilepsy (TLE), could significantly alter the response of dendrites to theta inputs. Here we report a progressive erosion of theta resonance and phase lead in pyramidal cell dendrites during epileptogenesis in a rat model of TLE. These alterations were due to decreased Ih availability, via a decline in HCN1/HCN2 subunit expression resulting in decreased h currents, and altered kinetics of the residual channels. This acquired HCN channelopathy thus compromises temporal coding and tuning to theta inputs in pyramidal cell dendrites. Decreased theta resonance in vitro also correlated with a reduction in theta frequency and power in vivo. We suggest that the neuronal/circuitry changes associated with TLE, including altered Ih-dependent inductive mechanisms, can disrupt hippocampal theta function.http://www.sciencedirect.com/science/article/pii/S096999610800301XEpilepsyHCN channelDendriteTheta rhythmResonanceOscillation |
| spellingShingle | Béatrice Marcelin Laëtitia Chauvière Albert Becker Michele Migliore Monique Esclapez Christophe Bernard h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy Neurobiology of Disease Epilepsy HCN channel Dendrite Theta rhythm Resonance Oscillation |
| title | h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy |
| title_full | h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy |
| title_fullStr | h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy |
| title_full_unstemmed | h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy |
| title_short | h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy |
| title_sort | h channel dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy |
| topic | Epilepsy HCN channel Dendrite Theta rhythm Resonance Oscillation |
| url | http://www.sciencedirect.com/science/article/pii/S096999610800301X |
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