Nueva generación de vacunas antimeningococica basadas en vesículas de membrana externa
With the development of conjugate vaccines, Neisseria meningitidis serogroup B (MenB) will remain the major cause of meningitis, as it is not covered by vaccination. In order to develop a vaccine able to confer a broad cross-protection against invasive MenB strains, we have developed a new generatio...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Finlay Ediciones
2009-08-01
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| Series: | VacciMonitor |
| Subjects: | |
| Online Access: | http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-028X2009000200005&lng=es&nrm=iso |
| Summary: | With the development of conjugate vaccines, Neisseria meningitidis serogroup B (MenB) will remain the major cause of meningitis, as it is not covered by vaccination. In order to develop a vaccine able to confer a broad cross-protection against invasive MenB strains, we have developed a new generation of outer-membrane vesicles (OMVs) based on the over-expression of well conserved minor outer membrane proteins (OMPs) and the presence of high percentage of detoxified LOS. |
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| ISSN: | 1025-028X 1025-0298 |