Evaluation of adenosine deaminase activity for diagnosis of tuberculous pleural effusion
<p><strong>Background: </strong>Tuberculosis is a leading cause of worldwide preventable morbidity and mortality from an infectious agent. A defi nite diagnosis of tubercular pleural effusion can be diffi cult to make because of low sensitivity and/or specifi city of noninvasive tr...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Association of Clinical Pathologists of Nepal
2013-03-01
|
| Series: | Journal of Pathology of Nepal |
| Subjects: | |
| Online Access: | http://www.nepjol.info/index.php/JPN/article/view/7860 |
| _version_ | 1818042950481870848 |
|---|---|
| author | SK Bhoumik MM Rahman M Ibrahim MM Hiron M Ahamad |
| author_facet | SK Bhoumik MM Rahman M Ibrahim MM Hiron M Ahamad |
| author_sort | SK Bhoumik |
| collection | DOAJ |
| description | <p><strong>Background: </strong>Tuberculosis is a leading cause of worldwide preventable morbidity and mortality from an infectious agent. A defi nite diagnosis of tubercular pleural effusion can be diffi cult to make because of low sensitivity and/or specifi city of noninvasive traditional diagnostic tools. This study is done to fi nd out a sensitive and specifi c marker for early diagnosis of tuberculous pleural effusion.</p> <p><strong>Materials and Methods: </strong>One hundred and three pleural effusion cases were enrolled in the study, out of which 62 were tuberculous pleural effusion cases and 49 were non-tuberculous cases.</p> <p><strong>Results: </strong>Considering 40 U/L as a cut off value for Adenosine deaminase assay level, the test result was positive in 58 out of 62 patients of tuberculosis indicating sensitivity of the test as 94%; however, among 41 non-tuberculous patients, 5 presented ADA activity level more than 40U/L, which lowers the specifi city of the test to 88%. ADA levels were signifi cantly higher in tuberculous than in non tuberculous cases (P value <0.001).</p> <p><strong>Conclusion: </strong>It may be concluded that ADA levels are signifi cantly high in patients with tuberculous pleural effusion compared to that in non tuberculous group. Sensitivity (94%) and specifi city (88%) of the test in tuberculous pleural effusions are very high, when cut off value set at 40U/L. The result indicated that the analysis of ADA levels in pleural effusion constitute a very useful marker for the diagnosis of TPE which, in addition, can be made quickly in a non- invasive way.</p> <p>Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 367-373</p> <p>DOI: <a href="http://dx.doi.org/10.3126/jpn.v3i5.7860">http://dx.doi.org/10.3126/jpn.v3i5.7860</a></p> |
| first_indexed | 2024-12-10T08:54:27Z |
| format | Article |
| id | doaj.art-f17320e2076a465e8c54506418d2d879 |
| institution | Directory Open Access Journal |
| issn | 2091-0797 2091-0908 |
| language | English |
| last_indexed | 2024-12-10T08:54:27Z |
| publishDate | 2013-03-01 |
| publisher | Association of Clinical Pathologists of Nepal |
| record_format | Article |
| series | Journal of Pathology of Nepal |
| spelling | doaj.art-f17320e2076a465e8c54506418d2d8792022-12-22T01:55:29ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082013-03-013536737310.3126/jpn.v3i5.78606328Evaluation of adenosine deaminase activity for diagnosis of tuberculous pleural effusionSK Bhoumik0MM Rahman1M Ibrahim2MM Hiron3M Ahamad4Department of Medicine, National Institute of Disease of the Chest and Hospital, Dhaka,Department of Medicine, National Institute of Disease of the Chest and Hospital, Dhaka,Department of Clinical Biochemistry, Lab Medicine Apollo Hospital, Dhaka,Department of Medicine, National Institute of Disease of the Chest and Hospital, Dhaka,Department of Respiratory medicine, Dhaka Medical College, Dhaka,<p><strong>Background: </strong>Tuberculosis is a leading cause of worldwide preventable morbidity and mortality from an infectious agent. A defi nite diagnosis of tubercular pleural effusion can be diffi cult to make because of low sensitivity and/or specifi city of noninvasive traditional diagnostic tools. This study is done to fi nd out a sensitive and specifi c marker for early diagnosis of tuberculous pleural effusion.</p> <p><strong>Materials and Methods: </strong>One hundred and three pleural effusion cases were enrolled in the study, out of which 62 were tuberculous pleural effusion cases and 49 were non-tuberculous cases.</p> <p><strong>Results: </strong>Considering 40 U/L as a cut off value for Adenosine deaminase assay level, the test result was positive in 58 out of 62 patients of tuberculosis indicating sensitivity of the test as 94%; however, among 41 non-tuberculous patients, 5 presented ADA activity level more than 40U/L, which lowers the specifi city of the test to 88%. ADA levels were signifi cantly higher in tuberculous than in non tuberculous cases (P value <0.001).</p> <p><strong>Conclusion: </strong>It may be concluded that ADA levels are signifi cantly high in patients with tuberculous pleural effusion compared to that in non tuberculous group. Sensitivity (94%) and specifi city (88%) of the test in tuberculous pleural effusions are very high, when cut off value set at 40U/L. The result indicated that the analysis of ADA levels in pleural effusion constitute a very useful marker for the diagnosis of TPE which, in addition, can be made quickly in a non- invasive way.</p> <p>Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 367-373</p> <p>DOI: <a href="http://dx.doi.org/10.3126/jpn.v3i5.7860">http://dx.doi.org/10.3126/jpn.v3i5.7860</a></p>http://www.nepjol.info/index.php/JPN/article/view/7860Adenosine deaminasePleural EffusionTuberculosis |
| spellingShingle | SK Bhoumik MM Rahman M Ibrahim MM Hiron M Ahamad Evaluation of adenosine deaminase activity for diagnosis of tuberculous pleural effusion Journal of Pathology of Nepal Adenosine deaminase Pleural Effusion Tuberculosis |
| title | Evaluation of adenosine deaminase activity for diagnosis of tuberculous pleural effusion |
| title_full | Evaluation of adenosine deaminase activity for diagnosis of tuberculous pleural effusion |
| title_fullStr | Evaluation of adenosine deaminase activity for diagnosis of tuberculous pleural effusion |
| title_full_unstemmed | Evaluation of adenosine deaminase activity for diagnosis of tuberculous pleural effusion |
| title_short | Evaluation of adenosine deaminase activity for diagnosis of tuberculous pleural effusion |
| title_sort | evaluation of adenosine deaminase activity for diagnosis of tuberculous pleural effusion |
| topic | Adenosine deaminase Pleural Effusion Tuberculosis |
| url | http://www.nepjol.info/index.php/JPN/article/view/7860 |
| work_keys_str_mv | AT skbhoumik evaluationofadenosinedeaminaseactivityfordiagnosisoftuberculouspleuraleffusion AT mmrahman evaluationofadenosinedeaminaseactivityfordiagnosisoftuberculouspleuraleffusion AT mibrahim evaluationofadenosinedeaminaseactivityfordiagnosisoftuberculouspleuraleffusion AT mmhiron evaluationofadenosinedeaminaseactivityfordiagnosisoftuberculouspleuraleffusion AT mahamad evaluationofadenosinedeaminaseactivityfordiagnosisoftuberculouspleuraleffusion |