Serum Cystatin C Reflects the Progress of Albuminuria
BackgroundResearch on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate.MethodsWe en...
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2011-12-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-602.pdf |
| _version_ | 1819211928888672256 |
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| author | Jeong Seon Yoo Young Mi Lee Eun Hae Lee Ji Woon Kim Shin Young Lee Ki-Cheon Jeong Shin Ae Kang Jong Suk Park Joo Young Nam Chul Woo Ahn Young Duk Song Kyung Rae Kim |
| author_facet | Jeong Seon Yoo Young Mi Lee Eun Hae Lee Ji Woon Kim Shin Young Lee Ki-Cheon Jeong Shin Ae Kang Jong Suk Park Joo Young Nam Chul Woo Ahn Young Duk Song Kyung Rae Kim |
| author_sort | Jeong Seon Yoo |
| collection | DOAJ |
| description | BackgroundResearch on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate.MethodsWe enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic.ResultsWith the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR.ConclusionSerum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients. |
| first_indexed | 2024-12-23T06:34:52Z |
| format | Article |
| id | doaj.art-f1742450d1fb4ada876a37769fdf3acf |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-23T06:34:52Z |
| publishDate | 2011-12-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-f1742450d1fb4ada876a37769fdf3acf2022-12-21T17:56:50ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872011-12-0135660260910.4093/dmj.2011.35.6.6022624Serum Cystatin C Reflects the Progress of AlbuminuriaJeong Seon YooYoung Mi LeeEun Hae LeeJi Woon KimShin Young LeeKi-Cheon JeongShin Ae KangJong Suk ParkJoo Young NamChul Woo AhnYoung Duk SongKyung Rae KimBackgroundResearch on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate.MethodsWe enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic.ResultsWith the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR.ConclusionSerum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-602.pdfAlbuminuriaCystatin CCreatinineDiabetes mellitus, type 2Diabetic nephropathies |
| spellingShingle | Jeong Seon Yoo Young Mi Lee Eun Hae Lee Ji Woon Kim Shin Young Lee Ki-Cheon Jeong Shin Ae Kang Jong Suk Park Joo Young Nam Chul Woo Ahn Young Duk Song Kyung Rae Kim Serum Cystatin C Reflects the Progress of Albuminuria Diabetes & Metabolism Journal Albuminuria Cystatin C Creatinine Diabetes mellitus, type 2 Diabetic nephropathies |
| title | Serum Cystatin C Reflects the Progress of Albuminuria |
| title_full | Serum Cystatin C Reflects the Progress of Albuminuria |
| title_fullStr | Serum Cystatin C Reflects the Progress of Albuminuria |
| title_full_unstemmed | Serum Cystatin C Reflects the Progress of Albuminuria |
| title_short | Serum Cystatin C Reflects the Progress of Albuminuria |
| title_sort | serum cystatin c reflects the progress of albuminuria |
| topic | Albuminuria Cystatin C Creatinine Diabetes mellitus, type 2 Diabetic nephropathies |
| url | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-602.pdf |
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