Elevated mature monocytes in bone marrow accompanied with a higher IPSS-R score predicts a poor prognosis in myelodysplastic syndromes
Abstract Background Myelodysplastic syndromes (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. Clinically, elevated mature monocyte in bone marrow is often observed, but its clinical value still remains unclear. Methods We retrospectively analyzed...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-05-01
|
| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-021-08303-8 |
| _version_ | 1818454106389348352 |
|---|---|
| author | An Wu Panpan Gao Ningning Wu Cong Shi Zhenya Huang Chunmeng Rong Ye Sun Lixia Sheng Guifang Ouyang Qitian Mu |
| author_facet | An Wu Panpan Gao Ningning Wu Cong Shi Zhenya Huang Chunmeng Rong Ye Sun Lixia Sheng Guifang Ouyang Qitian Mu |
| author_sort | An Wu |
| collection | DOAJ |
| description | Abstract Background Myelodysplastic syndromes (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. Clinically, elevated mature monocyte in bone marrow is often observed, but its clinical value still remains unclear. Methods We retrospectively analyzed a cohort of 216 MDS patients to explore the prognostic value of the percentage of mature monocyte in bone marrow (PMMBM). All patients were divided into elevated PMMBM group and the normal group by 6% PMMBM as the cut-off value. Results Our results showed that PMMBM> 6% was associated with inferior overall survival (OS) (P = 0.026) along with higher-risk IPSS-R (P = 0.025) and higher frequency of IDH2 mutation (P = 0.007). Multivariate analyses showed that besides older age (> 60 years) for OS, gender (male) for OS, lower neutrophil count (< 0.8 × 109/L) for OS, higher bone marrow blast percentage (> 5%) for OS and LFS, poorer karyotype for OS, elevated PMMBM was also an independent adverse prognostic factor for OS in MDS (P < 0.0001) but not for LFS (P = 0.736). Conclusions These findings indicate that increased PMMBM may assists Revised International Prognostic Scoring System (IPSS-R) to predict a poor outcome and provide a novel evaluation factor for MDS patients especially when their karyotype analyses fail. |
| first_indexed | 2024-12-14T21:49:36Z |
| format | Article |
| id | doaj.art-f174b47fee934dd38118239da947d045 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-14T21:49:36Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-f174b47fee934dd38118239da947d0452022-12-21T22:46:16ZengBMCBMC Cancer1471-24072021-05-012111710.1186/s12885-021-08303-8Elevated mature monocytes in bone marrow accompanied with a higher IPSS-R score predicts a poor prognosis in myelodysplastic syndromesAn Wu0Panpan Gao1Ningning Wu2Cong Shi3Zhenya Huang4Chunmeng Rong5Ye Sun6Lixia Sheng7Guifang Ouyang8Qitian Mu9Department of Hematology, Ningbo First HospitalDepartment of Hematology, Yuyao People’s Hospital of Zhejiang ProvinceDepartment of Hematology, Ningbo First HospitalDepartment of Hematology, Ningbo First HospitalDepartment of Hematology, Ningbo First HospitalDepartment of Hematology, Ningbo First HospitalDepartment of Hematology, Ningbo First HospitalDepartment of Hematology, Ningbo First HospitalDepartment of Hematology, Ningbo First HospitalDepartment of Hematology, Ningbo First HospitalAbstract Background Myelodysplastic syndromes (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. Clinically, elevated mature monocyte in bone marrow is often observed, but its clinical value still remains unclear. Methods We retrospectively analyzed a cohort of 216 MDS patients to explore the prognostic value of the percentage of mature monocyte in bone marrow (PMMBM). All patients were divided into elevated PMMBM group and the normal group by 6% PMMBM as the cut-off value. Results Our results showed that PMMBM> 6% was associated with inferior overall survival (OS) (P = 0.026) along with higher-risk IPSS-R (P = 0.025) and higher frequency of IDH2 mutation (P = 0.007). Multivariate analyses showed that besides older age (> 60 years) for OS, gender (male) for OS, lower neutrophil count (< 0.8 × 109/L) for OS, higher bone marrow blast percentage (> 5%) for OS and LFS, poorer karyotype for OS, elevated PMMBM was also an independent adverse prognostic factor for OS in MDS (P < 0.0001) but not for LFS (P = 0.736). Conclusions These findings indicate that increased PMMBM may assists Revised International Prognostic Scoring System (IPSS-R) to predict a poor outcome and provide a novel evaluation factor for MDS patients especially when their karyotype analyses fail.https://doi.org/10.1186/s12885-021-08303-8Mature monocyte in bone marrowMyelodysplastic syndromeIPSS-RPrognosis |
| spellingShingle | An Wu Panpan Gao Ningning Wu Cong Shi Zhenya Huang Chunmeng Rong Ye Sun Lixia Sheng Guifang Ouyang Qitian Mu Elevated mature monocytes in bone marrow accompanied with a higher IPSS-R score predicts a poor prognosis in myelodysplastic syndromes BMC Cancer Mature monocyte in bone marrow Myelodysplastic syndrome IPSS-R Prognosis |
| title | Elevated mature monocytes in bone marrow accompanied with a higher IPSS-R score predicts a poor prognosis in myelodysplastic syndromes |
| title_full | Elevated mature monocytes in bone marrow accompanied with a higher IPSS-R score predicts a poor prognosis in myelodysplastic syndromes |
| title_fullStr | Elevated mature monocytes in bone marrow accompanied with a higher IPSS-R score predicts a poor prognosis in myelodysplastic syndromes |
| title_full_unstemmed | Elevated mature monocytes in bone marrow accompanied with a higher IPSS-R score predicts a poor prognosis in myelodysplastic syndromes |
| title_short | Elevated mature monocytes in bone marrow accompanied with a higher IPSS-R score predicts a poor prognosis in myelodysplastic syndromes |
| title_sort | elevated mature monocytes in bone marrow accompanied with a higher ipss r score predicts a poor prognosis in myelodysplastic syndromes |
| topic | Mature monocyte in bone marrow Myelodysplastic syndrome IPSS-R Prognosis |
| url | https://doi.org/10.1186/s12885-021-08303-8 |
| work_keys_str_mv | AT anwu elevatedmaturemonocytesinbonemarrowaccompaniedwithahigheripssrscorepredictsapoorprognosisinmyelodysplasticsyndromes AT panpangao elevatedmaturemonocytesinbonemarrowaccompaniedwithahigheripssrscorepredictsapoorprognosisinmyelodysplasticsyndromes AT ningningwu elevatedmaturemonocytesinbonemarrowaccompaniedwithahigheripssrscorepredictsapoorprognosisinmyelodysplasticsyndromes AT congshi elevatedmaturemonocytesinbonemarrowaccompaniedwithahigheripssrscorepredictsapoorprognosisinmyelodysplasticsyndromes AT zhenyahuang elevatedmaturemonocytesinbonemarrowaccompaniedwithahigheripssrscorepredictsapoorprognosisinmyelodysplasticsyndromes AT chunmengrong elevatedmaturemonocytesinbonemarrowaccompaniedwithahigheripssrscorepredictsapoorprognosisinmyelodysplasticsyndromes AT yesun elevatedmaturemonocytesinbonemarrowaccompaniedwithahigheripssrscorepredictsapoorprognosisinmyelodysplasticsyndromes AT lixiasheng elevatedmaturemonocytesinbonemarrowaccompaniedwithahigheripssrscorepredictsapoorprognosisinmyelodysplasticsyndromes AT guifangouyang elevatedmaturemonocytesinbonemarrowaccompaniedwithahigheripssrscorepredictsapoorprognosisinmyelodysplasticsyndromes AT qitianmu elevatedmaturemonocytesinbonemarrowaccompaniedwithahigheripssrscorepredictsapoorprognosisinmyelodysplasticsyndromes |