COVID-19 and Antimicrobial Resistance: Data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance—WHONET-Greece (January 2018–March 2021)
Changes in hospitals’ daily practice due to COVID-19 pandemic may have an impact on antimicrobial resistance (AMR). We aimed to assess this possible impact as captured by the Greek Electronic System for the Surveillance of Antimicrobial Resistance (WHONET-Greece). Routine susceptibility data of 17,8...
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MDPI AG
2021-09-01
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| Online Access: | https://www.mdpi.com/2075-1729/11/10/996 |
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| author | Michalis Polemis Georgia Mandilara Olga Pappa Athina Argyropoulou Efstathia Perivolioti Nikolaos Koudoumnakis Spyros Pournaras Alexandra Vasilakopoulou Sophia Vourli Helen Katsifa Theodoros Karampatakis Anastasia Papavasiliou Efthymia Petinaki Stylianos Xitsas Lemonia Skoura Efthymia Protonotariou Paraskevi Mantzana Konstantina Gartzonika Efthalia Priavali Amalia Kallinteri Panagiota Giannopoulou Nikoletta Charalampaki Meletis Memezas Zervaki Calina Oana Marina Papadogianni Maria Panopoulou Athanasia Koutsidou Alkiviadis Vatopoulos Kyriaki Tryfinopoulou |
| author_facet | Michalis Polemis Georgia Mandilara Olga Pappa Athina Argyropoulou Efstathia Perivolioti Nikolaos Koudoumnakis Spyros Pournaras Alexandra Vasilakopoulou Sophia Vourli Helen Katsifa Theodoros Karampatakis Anastasia Papavasiliou Efthymia Petinaki Stylianos Xitsas Lemonia Skoura Efthymia Protonotariou Paraskevi Mantzana Konstantina Gartzonika Efthalia Priavali Amalia Kallinteri Panagiota Giannopoulou Nikoletta Charalampaki Meletis Memezas Zervaki Calina Oana Marina Papadogianni Maria Panopoulou Athanasia Koutsidou Alkiviadis Vatopoulos Kyriaki Tryfinopoulou |
| author_sort | Michalis Polemis |
| collection | DOAJ |
| description | Changes in hospitals’ daily practice due to COVID-19 pandemic may have an impact on antimicrobial resistance (AMR). We aimed to assess this possible impact as captured by the Greek Electronic System for the Surveillance of Antimicrobial Resistance (WHONET-Greece). Routine susceptibility data of 17,837 Gram-negative and Gram-positive bacterial isolates from blood and respiratory specimens of hospitalized patients in nine COVID-19 tertiary hospitals were used in order to identify potential differences in AMR trends in the last three years, divided into two periods, January 2018–March 2020 and April 2020–March 2021. Interrupted time-series analysis was used to evaluate differences in the trends of non-susceptibility before and after the changes due to COVID-19. We found significant differences in the slope of non-susceptibility trends of <i>Acinetobacter baumannii</i> blood and respiratory isolates to amikacin, tigecycline and colistin; of <i>Klebsiella pneumoniae</i> blood and respiratory isolates to meropenem and tigecycline; and of <i>Pseudomonas aeruginosa</i> respiratory isolates to imipenem, meropenem and levofloxacin. Additionally, we found significant differences in the slope of non-susceptibility trends of <i>Staphylococcus aureus</i> isolates to oxacillin and of <i>Enterococcus faecium</i> isolates to glycopeptides. Assessing in this early stage, through surveillance of routine laboratory data, the way a new global threat like COVID-19 could affect an already ongoing pandemic like AMR provides useful information for prompt action. |
| first_indexed | 2024-03-10T06:27:26Z |
| format | Article |
| id | doaj.art-f176051b011e4e2aa9e416d8070282c1 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T06:27:26Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-f176051b011e4e2aa9e416d8070282c12023-11-22T18:51:51ZengMDPI AGLife2075-17292021-09-01111099610.3390/life11100996COVID-19 and Antimicrobial Resistance: Data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance—WHONET-Greece (January 2018–March 2021)Michalis Polemis0Georgia Mandilara1Olga Pappa2Athina Argyropoulou3Efstathia Perivolioti4Nikolaos Koudoumnakis5Spyros Pournaras6Alexandra Vasilakopoulou7Sophia Vourli8Helen Katsifa9Theodoros Karampatakis10Anastasia Papavasiliou11Efthymia Petinaki12Stylianos Xitsas13Lemonia Skoura14Efthymia Protonotariou15Paraskevi Mantzana16Konstantina Gartzonika17Efthalia Priavali18Amalia Kallinteri19Panagiota Giannopoulou20Nikoletta Charalampaki21Meletis Memezas22Zervaki Calina Oana23Marina Papadogianni24Maria Panopoulou25Athanasia Koutsidou26Alkiviadis Vatopoulos27Kyriaki Tryfinopoulou28Central Public Health Laboratory, National Public Health Organization, 16672 Vari, GreeceSchool of Public Health, University of West Attica, 11521 Athens, GreeceCentral Public Health Laboratory, National Public Health Organization, 16672 Vari, Greece“Evaggelismos” General Hospital, 10676 Athens, Greece“Evaggelismos” General Hospital, 10676 Athens, Greece“Evaggelismos” General Hospital, 10676 Athens, Greece“Attikon” University Hospital, 12462 Athens, Greece“Attikon” University Hospital, 12462 Athens, Greece“Attikon” University Hospital, 12462 Athens, GreeceGeneral Hospital “George Papanikolaou”, 57010 Thessaloniki, GreeceGeneral Hospital “George Papanikolaou”, 57010 Thessaloniki, GreeceGeneral Hospital “George Papanikolaou”, 57010 Thessaloniki, GreeceUniversity Hospital of Larissa, 41110 Larissa, GreeceUniversity Hospital of Larissa, 41110 Larissa, Greece“Axepa” University Hospital, 54636 Thessaloniki, Greece“Axepa” University Hospital, 54636 Thessaloniki, Greece“Axepa” University Hospital, 54636 Thessaloniki, GreeceUniversity Hospital of Ioannina, 45500 Ioannina, GreeceUniversity Hospital of Ioannina, 45500 Ioannina, GreeceUniversity Hospital of Ioannina, 45500 Ioannina, Greece“Thriasio” General Hospital of Elefsina, 19600 Athens, Greece“Thriasio” General Hospital of Elefsina, 19600 Athens, Greece“Thriasio” General Hospital of Elefsina, 19600 Athens, Greece“St. George” General Hospital, 73300 Crete (Chania), Greece“St. George” General Hospital, 73300 Crete (Chania), GreeceUniversity Hospital of Alexandroupolis, 68100 Alexandroupoli, GreeceUniversity Hospital of Alexandroupolis, 68100 Alexandroupoli, GreeceSchool of Public Health, University of West Attica, 11521 Athens, GreeceCentral Public Health Laboratory, National Public Health Organization, 16672 Vari, GreeceChanges in hospitals’ daily practice due to COVID-19 pandemic may have an impact on antimicrobial resistance (AMR). We aimed to assess this possible impact as captured by the Greek Electronic System for the Surveillance of Antimicrobial Resistance (WHONET-Greece). Routine susceptibility data of 17,837 Gram-negative and Gram-positive bacterial isolates from blood and respiratory specimens of hospitalized patients in nine COVID-19 tertiary hospitals were used in order to identify potential differences in AMR trends in the last three years, divided into two periods, January 2018–March 2020 and April 2020–March 2021. Interrupted time-series analysis was used to evaluate differences in the trends of non-susceptibility before and after the changes due to COVID-19. We found significant differences in the slope of non-susceptibility trends of <i>Acinetobacter baumannii</i> blood and respiratory isolates to amikacin, tigecycline and colistin; of <i>Klebsiella pneumoniae</i> blood and respiratory isolates to meropenem and tigecycline; and of <i>Pseudomonas aeruginosa</i> respiratory isolates to imipenem, meropenem and levofloxacin. Additionally, we found significant differences in the slope of non-susceptibility trends of <i>Staphylococcus aureus</i> isolates to oxacillin and of <i>Enterococcus faecium</i> isolates to glycopeptides. Assessing in this early stage, through surveillance of routine laboratory data, the way a new global threat like COVID-19 could affect an already ongoing pandemic like AMR provides useful information for prompt action.https://www.mdpi.com/2075-1729/11/10/996antimicrobial resistanceCOVID-19routine laboratory datasurveillance system |
| spellingShingle | Michalis Polemis Georgia Mandilara Olga Pappa Athina Argyropoulou Efstathia Perivolioti Nikolaos Koudoumnakis Spyros Pournaras Alexandra Vasilakopoulou Sophia Vourli Helen Katsifa Theodoros Karampatakis Anastasia Papavasiliou Efthymia Petinaki Stylianos Xitsas Lemonia Skoura Efthymia Protonotariou Paraskevi Mantzana Konstantina Gartzonika Efthalia Priavali Amalia Kallinteri Panagiota Giannopoulou Nikoletta Charalampaki Meletis Memezas Zervaki Calina Oana Marina Papadogianni Maria Panopoulou Athanasia Koutsidou Alkiviadis Vatopoulos Kyriaki Tryfinopoulou COVID-19 and Antimicrobial Resistance: Data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance—WHONET-Greece (January 2018–March 2021) Life antimicrobial resistance COVID-19 routine laboratory data surveillance system |
| title | COVID-19 and Antimicrobial Resistance: Data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance—WHONET-Greece (January 2018–March 2021) |
| title_full | COVID-19 and Antimicrobial Resistance: Data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance—WHONET-Greece (January 2018–March 2021) |
| title_fullStr | COVID-19 and Antimicrobial Resistance: Data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance—WHONET-Greece (January 2018–March 2021) |
| title_full_unstemmed | COVID-19 and Antimicrobial Resistance: Data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance—WHONET-Greece (January 2018–March 2021) |
| title_short | COVID-19 and Antimicrobial Resistance: Data from the Greek Electronic System for the Surveillance of Antimicrobial Resistance—WHONET-Greece (January 2018–March 2021) |
| title_sort | covid 19 and antimicrobial resistance data from the greek electronic system for the surveillance of antimicrobial resistance whonet greece january 2018 march 2021 |
| topic | antimicrobial resistance COVID-19 routine laboratory data surveillance system |
| url | https://www.mdpi.com/2075-1729/11/10/996 |
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