Correlation of HbA1c and Insulin Resistance with Urine Albumin Excretion in Non Diabetic Obese Population: A Cross-sectional Study
Introduction: A number of metabolic disorders are linked to obesity, which is a global health concern. Although renal impairment is a serious side-effect of obesity, its connection to insulin resistance is still a subject of discussion. Aim: To assess the correlation between microalbuminuria an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2023-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/18667/67615_F(SS)_QC(AKA_RDW_IS)_PF1(AG_OM)_PFA(AG_KM)_PN(KM).pdf |
| Summary: | Introduction: A number of metabolic disorders are linked
to obesity, which is a global health concern. Although renal
impairment is a serious side-effect of obesity, its connection to
insulin resistance is still a subject of discussion.
Aim: To assess the correlation between microalbuminuria
and HbA1c levels, as well as the association between Insulin
Resistance (IR) and renal function in obese individuals.
Materials and Methods: The present study was a crosssectional study conducted in patients attending the obesity
clinic, in Endocrinology department, of a tertiary hospital in
Kerala, India. A total of 144 obese individuals participated,
meeting age, Body Mass Index (BMI), and health-related.
Insulin resistance was measured using Homeostatic Model
Assessment for Insulin Resistance (HOMA-IR), while renal
function was measured using the Urine Albumin Creatinine
Ratio (UACR). Correlation analysis was conducted to investigate
relationships between variables.
Results: The study found a weak association between UACR
and HbA1c levels and insulin resistance (r-value=0.159,
p-value=0.056). Subjects with insulin resistance had significantly
higher levels of microalbuminuria. Despite these connections,
the mean UACR levels remained within the typical reference
range.
Conclusion: This study emphasises the importance of early
renal health screening in obese individuals, with HbA1c and
microalbuminuria measurements as promising methods for
preventing kidney impairment. To establish causation in the
complex interplay between metabolic variables and renal
function in obesity and insulin resistance, future research
should focus on understanding the underlying mechanisms and
conducting longitudinal examinations. |
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| ISSN: | 2249-782X 0973-709X |