Insights into the modulation of bacterial NADase activity by phage proteins

Insights into the modulation of bacterial NADase activity by phage proteins

Abstract The Silent Information Regulator 2 (SIR2) protein is widely implicated in antiviral response by depleting the cellular metabolite NAD+. The defense-associated sirtuin 2 (DSR2) effector, a SIR2 domain-containing protein, protects bacteria from phage infection by depleting NAD+, while an anti...

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Bibliographic Details
Main Authors: Hang Yin, Xuzichao Li, Xiaoshen Wang, Chendi Zhang, Jiaqi Gao, Guimei Yu, Qiuqiu He, Jie Yang, Xiang Liu, Yong Wei, Zhuang Li, Heng Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47030-z

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