Revisiting the application of Immobilized Artificial Membrane (IAM) chromatography to estimate in vivo distribution properties of drug discovery compounds based on the model of marketed drugs
Immobilized Artificial Membrane (IAM) chromatography columns have been used to model the in vivo distribution of drug discovery compounds. Regis Technologies Inc., the manufacturer, had to replace the silica support and consequently introduced a new IAM.PC.DD2 column that shows slightly different se...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Association of Physical Chemists (IAPC)
2020-03-01
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| Series: | ADMET and DMPK |
| Subjects: | |
| Online Access: | http://pub.iapchem.org/ojs/index.php/admet/article/view/757 |
| _version_ | 1828749852321775616 |
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| author | Klara Livia Valko Silvia Rava Shenaz Bunally Scott Anderson |
| author_facet | Klara Livia Valko Silvia Rava Shenaz Bunally Scott Anderson |
| author_sort | Klara Livia Valko |
| collection | DOAJ |
| description | Immobilized Artificial Membrane (IAM) chromatography columns have been used to model the in vivo distribution of drug discovery compounds. Regis Technologies Inc., the manufacturer, had to replace the silica support and consequently introduced a new IAM.PC.DD2 column that shows slightly different selectivity towards acidic and basic compounds. The application of the new IAM.PC.DD2 columns has been evaluated and the in vivo distribution models have been compared with the previous batches of columns. It was found that due to the improved endcapping of the silica, some of the positively charged drug molecules showed shorter retention than previously published. Therefore, the column system suitability data have been updated. However, these differences do not significantly affect the previously published models for the volume of distribution, brain tissue binding and drug efficiency. Therefore, the published models can be used with the new IAM.PC.DD2 columns. |
| first_indexed | 2024-12-10T20:29:23Z |
| format | Article |
| id | doaj.art-f177dd5c00074a2c8192e4b16ef34ba6 |
| institution | Directory Open Access Journal |
| issn | 1848-7718 |
| language | English |
| last_indexed | 2024-12-10T20:29:23Z |
| publishDate | 2020-03-01 |
| publisher | International Association of Physical Chemists (IAPC) |
| record_format | Article |
| series | ADMET and DMPK |
| spelling | doaj.art-f177dd5c00074a2c8192e4b16ef34ba62022-12-22T01:34:45ZengInternational Association of Physical Chemists (IAPC)ADMET and DMPK1848-77182020-03-0181789710.5599/admet.757410Revisiting the application of Immobilized Artificial Membrane (IAM) chromatography to estimate in vivo distribution properties of drug discovery compounds based on the model of marketed drugsKlara Livia Valko0Silvia Rava1Shenaz Bunally2Scott Anderson3Bio-Mimetic Chromatography, Director Honorary Professor UCL School of Pharmacy1University of Pavia, Italy, Erasmus internship at Bio-Mimetic Chromatography Ltd. Business and Technology Centre, Bessemer Drive, Stevenage, SG1 2DX, United KingdomHead of Physicochemical Characterization Group at GSK, Stevenage United KingdomProduct manager at Regis Technologies Inc.Immobilized Artificial Membrane (IAM) chromatography columns have been used to model the in vivo distribution of drug discovery compounds. Regis Technologies Inc., the manufacturer, had to replace the silica support and consequently introduced a new IAM.PC.DD2 column that shows slightly different selectivity towards acidic and basic compounds. The application of the new IAM.PC.DD2 columns has been evaluated and the in vivo distribution models have been compared with the previous batches of columns. It was found that due to the improved endcapping of the silica, some of the positively charged drug molecules showed shorter retention than previously published. Therefore, the column system suitability data have been updated. However, these differences do not significantly affect the previously published models for the volume of distribution, brain tissue binding and drug efficiency. Therefore, the published models can be used with the new IAM.PC.DD2 columns.http://pub.iapchem.org/ojs/index.php/admet/article/view/757phospholipid binding, hplc, the volume of distribution, tissue binding, drug efficiency. |
| spellingShingle | Klara Livia Valko Silvia Rava Shenaz Bunally Scott Anderson Revisiting the application of Immobilized Artificial Membrane (IAM) chromatography to estimate in vivo distribution properties of drug discovery compounds based on the model of marketed drugs ADMET and DMPK phospholipid binding, hplc, the volume of distribution, tissue binding, drug efficiency. |
| title | Revisiting the application of Immobilized Artificial Membrane (IAM) chromatography to estimate in vivo distribution properties of drug discovery compounds based on the model of marketed drugs |
| title_full | Revisiting the application of Immobilized Artificial Membrane (IAM) chromatography to estimate in vivo distribution properties of drug discovery compounds based on the model of marketed drugs |
| title_fullStr | Revisiting the application of Immobilized Artificial Membrane (IAM) chromatography to estimate in vivo distribution properties of drug discovery compounds based on the model of marketed drugs |
| title_full_unstemmed | Revisiting the application of Immobilized Artificial Membrane (IAM) chromatography to estimate in vivo distribution properties of drug discovery compounds based on the model of marketed drugs |
| title_short | Revisiting the application of Immobilized Artificial Membrane (IAM) chromatography to estimate in vivo distribution properties of drug discovery compounds based on the model of marketed drugs |
| title_sort | revisiting the application of immobilized artificial membrane iam chromatography to estimate in vivo distribution properties of drug discovery compounds based on the model of marketed drugs |
| topic | phospholipid binding, hplc, the volume of distribution, tissue binding, drug efficiency. |
| url | http://pub.iapchem.org/ojs/index.php/admet/article/view/757 |
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