The Correlation between endothelin-1 antibody plasma concentrations in patients with scleroderma and different manifestations of the disease
"n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 st1":*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; ms...
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| Format: | Article |
| Language: | fas |
| Published: |
Tehran University of Medical Sciences
2011-03-01
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| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/17812.pdf&manuscript_id=17812 |
| _version_ | 1819063730984452096 |
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| author | Aghaei M Gharibdost F Zayeni H Akhlaghi M Sedighi S Rostamian AR Aghdami N Shojaa M |
| author_facet | Aghaei M Gharibdost F Zayeni H Akhlaghi M Sedighi S Rostamian AR Aghdami N Shojaa M |
| author_sort | Aghaei M |
| collection | DOAJ |
| description | "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 st1":*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Systemic scleroderma (SSc) is a generalized connective tissue disorder of unknown origin which most notably is characterized by skin thickening and organ damage. Endothelin-1 (ET-1) antibody plays a role in skin fibrosis. The aim of this study was to determine the prevalence and correlation of different manifestations of SSc with ET-1 plasma levels."n"nMethods: This cross-sectional analytical study was conducted on 95 patients (91 women and four men) with scleroderma in 2006. The patients had been referred to the Rheumatology Clinic of Shariati Hospital in Tehran, Iran. The demographic data and signs and symptoms were entered in a questionnaire and endothelin-1 concentrations were measured. "n"nResults: The mean age of the patients was 38±12.29 years. Diffuse cutaneous SSc (dcSSc) was diagnosed in 52 and limited cutaneous SSc (lcSSc) in 43 patients. Raynaud's phenomenon (91%) was the most common manifestation in the patients. The relationship between the resorption of terminal phalanges due to fibrosis with the plasma concentration of Endothelin-1 was statistically significant (p=0.001). Pitting ulcers had significant relationships with endothelin-1 concentrations too (p<0.05). No other significant relationships were found between the other manifestation of the disease and Endothelin-1 concentration. "n"nConclusion: In this study, Reynaud's phenomenon was the most frequent sign in patients with scleroderma. Thus, it could serve as a tool for the diagnosis of scleroderma. As there were no significant relationships between the other manifestations of scleroderma with endothelin-1, a cohort study with a larger sample size is suggested. |
| first_indexed | 2024-12-21T15:19:20Z |
| format | Article |
| id | doaj.art-f1790a7bc5e8496f8663eb67c1d3bd24 |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-21T15:19:20Z |
| publishDate | 2011-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-f1790a7bc5e8496f8663eb67c1d3bd242022-12-21T18:59:05ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222011-03-016812699704The Correlation between endothelin-1 antibody plasma concentrations in patients with scleroderma and different manifestations of the diseaseAghaei MGharibdost FZayeni HAkhlaghi MSedighi SRostamian ARAghdami NShojaa M"n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 st1":*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Systemic scleroderma (SSc) is a generalized connective tissue disorder of unknown origin which most notably is characterized by skin thickening and organ damage. Endothelin-1 (ET-1) antibody plays a role in skin fibrosis. The aim of this study was to determine the prevalence and correlation of different manifestations of SSc with ET-1 plasma levels."n"nMethods: This cross-sectional analytical study was conducted on 95 patients (91 women and four men) with scleroderma in 2006. The patients had been referred to the Rheumatology Clinic of Shariati Hospital in Tehran, Iran. The demographic data and signs and symptoms were entered in a questionnaire and endothelin-1 concentrations were measured. "n"nResults: The mean age of the patients was 38±12.29 years. Diffuse cutaneous SSc (dcSSc) was diagnosed in 52 and limited cutaneous SSc (lcSSc) in 43 patients. Raynaud's phenomenon (91%) was the most common manifestation in the patients. The relationship between the resorption of terminal phalanges due to fibrosis with the plasma concentration of Endothelin-1 was statistically significant (p=0.001). Pitting ulcers had significant relationships with endothelin-1 concentrations too (p<0.05). No other significant relationships were found between the other manifestation of the disease and Endothelin-1 concentration. "n"nConclusion: In this study, Reynaud's phenomenon was the most frequent sign in patients with scleroderma. Thus, it could serve as a tool for the diagnosis of scleroderma. As there were no significant relationships between the other manifestations of scleroderma with endothelin-1, a cohort study with a larger sample size is suggested.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/17812.pdf&manuscript_id=17812EndothelineclinicalmanifestationRaynaud’s phenomenonscleroderma |
| spellingShingle | Aghaei M Gharibdost F Zayeni H Akhlaghi M Sedighi S Rostamian AR Aghdami N Shojaa M The Correlation between endothelin-1 antibody plasma concentrations in patients with scleroderma and different manifestations of the disease Tehran University Medical Journal Endotheline clinical manifestation Raynaud’s phenomenon scleroderma |
| title | The Correlation between endothelin-1 antibody plasma concentrations in patients with scleroderma and different manifestations of the disease |
| title_full | The Correlation between endothelin-1 antibody plasma concentrations in patients with scleroderma and different manifestations of the disease |
| title_fullStr | The Correlation between endothelin-1 antibody plasma concentrations in patients with scleroderma and different manifestations of the disease |
| title_full_unstemmed | The Correlation between endothelin-1 antibody plasma concentrations in patients with scleroderma and different manifestations of the disease |
| title_short | The Correlation between endothelin-1 antibody plasma concentrations in patients with scleroderma and different manifestations of the disease |
| title_sort | correlation between endothelin 1 antibody plasma concentrations in patients with scleroderma and different manifestations of the disease |
| topic | Endotheline clinical manifestation Raynaud’s phenomenon scleroderma |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/17812.pdf&manuscript_id=17812 |
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