Tubastatin A Improves Post‐Resuscitation Myocardial Dysfunction by Inhibiting NLRP3‐Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling

Tubastatin A Improves Post‐Resuscitation Myocardial Dysfunction by Inhibiting NLRP3‐Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling

Background Myocardial dysfunction is the leading cause of early death following successful cardiopulmonary resuscitation (CPR) in people with cardiac arrest (CA), which is potentially driven by cell pyroptosis mediated by NOD‐like receptor pyrin domain 3 (NLRP3) inflammasome. Recently, histone deace...

Full description

Bibliographic Details
Main Authors: Jiefeng Xu, Xue Zhao, Xiangkang Jiang, Lu He, Xinjie Wu, Jiangang Wang, Qijiang Chen, Yulin Li, Mao Zhang
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiopulmonary resuscitation
cell pyroptosis
myocardial dysfunction
transcription factor EB
tubastatin A
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.024205

Similar Items

Similar Items