Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines Worldwide
Head and neck cancer (HNC) treatments have been based on single or multimodal therapies with surgery, radiotherapy (RT), chemotherapy, and immunotherapy. However, treatment recommendations among countries may differ due to technological/human resources and usual local practices. This scoping review...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/17/4405 |
| _version_ | 1797582771106873344 |
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| author | Lady Paola Aristizabal Arboleda Genival Barbosa de Carvalho Alan Roger Santos-Silva Gisele Aparecida Fernandes Jose Guilherme Vartanian David I. Conway Shama Virani Paul Brennan Luiz Paulo Kowalski Maria Paula Curado |
| author_facet | Lady Paola Aristizabal Arboleda Genival Barbosa de Carvalho Alan Roger Santos-Silva Gisele Aparecida Fernandes Jose Guilherme Vartanian David I. Conway Shama Virani Paul Brennan Luiz Paulo Kowalski Maria Paula Curado |
| author_sort | Lady Paola Aristizabal Arboleda |
| collection | DOAJ |
| description | Head and neck cancer (HNC) treatments have been based on single or multimodal therapies with surgery, radiotherapy (RT), chemotherapy, and immunotherapy. However, treatment recommendations among countries may differ due to technological/human resources and usual local practices. This scoping review aims to identify, compare, and map the clinical practice guidelines (CPGs) for treating squamous cell carcinoma (SCC) of the oral cavity, oropharynx, and larynx worldwide. A search strategy on global CPGs for HNC was performed by using five electronic databases and grey literature. CPGs were selected for inclusion using EndNote-20 and Rayyan online software. No language or publication date restrictions were applied. The results were analyzed descriptively considering the most updated CPG version. In total, 25 CPGs covering the head and neck region (10), the larynx (7), the oral cavity (5), and the oropharynx (3), were found in 13 geographical regions, and 19 were developed by medical societies from 1996 to 2023. Surgery and RT remain the main modalities for early-stage HNC, with surgery preferred in low-resource countries, and RT in selected cases, especially in the larynx/oropharynx aiming to achieve a cure with organ preservation. Human papillomavirus infection for oropharyngeal SCC is not tested in some Asian countries and there is still no consensus to treat p16-positive cases differently from p16-negative. Recommendations for larynx preservation vary according to facilities in each country, however, individualized choice is emphasized. Inequality across countries/continents is evident, with a similar pattern of recommendations among developed as well as developing ones. No CPGs were found in Latin America as well as Oceania countries, where the incidence of HNC is high and limitations of access to treatment may be encountered. |
| first_indexed | 2024-03-10T23:27:15Z |
| format | Article |
| id | doaj.art-f17ad4f46d984dbda1092007c75041c7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T23:27:15Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f17ad4f46d984dbda1092007c75041c72023-11-19T07:57:18ZengMDPI AGCancers2072-66942023-09-011517440510.3390/cancers15174405Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines WorldwideLady Paola Aristizabal Arboleda0Genival Barbosa de Carvalho1Alan Roger Santos-Silva2Gisele Aparecida Fernandes3Jose Guilherme Vartanian4David I. Conway5Shama Virani6Paul Brennan7Luiz Paulo Kowalski8Maria Paula Curado9Graduate Program of A.C.Camargo Cancer Center, Sao Paulo 01508-020, BrazilDepartment of Head and Neck Surgery and Otorhinolaryngology, A.C.Camargo Cancer Center, Sao Paulo 01508-020, BrazilOral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba 13414-903, BrazilGroup of Epidemiology and Statistics on Cancer, A.C.Camargo Cancer Center, Rua Tagua, 440, Liberdade, Sao Paulo CEP 01508-020, BrazilDepartment of Head and Neck Surgery and Otorhinolaryngology, A.C.Camargo Cancer Center, Sao Paulo 01508-020, BrazilSchool of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow G2 3JZ, UKGenomic Epidemiology Group, International Agency for Research on Cancer (IARC/WHO), G2 3JZ Lyon, FranceGenomic Epidemiology Group, International Agency for Research on Cancer (IARC/WHO), G2 3JZ Lyon, FranceDepartment of Head and Neck Surgery and Otorhinolaryngology, A.C.Camargo Cancer Center, Sao Paulo 01508-020, BrazilGroup of Epidemiology and Statistics on Cancer, A.C.Camargo Cancer Center, Rua Tagua, 440, Liberdade, Sao Paulo CEP 01508-020, BrazilHead and neck cancer (HNC) treatments have been based on single or multimodal therapies with surgery, radiotherapy (RT), chemotherapy, and immunotherapy. However, treatment recommendations among countries may differ due to technological/human resources and usual local practices. This scoping review aims to identify, compare, and map the clinical practice guidelines (CPGs) for treating squamous cell carcinoma (SCC) of the oral cavity, oropharynx, and larynx worldwide. A search strategy on global CPGs for HNC was performed by using five electronic databases and grey literature. CPGs were selected for inclusion using EndNote-20 and Rayyan online software. No language or publication date restrictions were applied. The results were analyzed descriptively considering the most updated CPG version. In total, 25 CPGs covering the head and neck region (10), the larynx (7), the oral cavity (5), and the oropharynx (3), were found in 13 geographical regions, and 19 were developed by medical societies from 1996 to 2023. Surgery and RT remain the main modalities for early-stage HNC, with surgery preferred in low-resource countries, and RT in selected cases, especially in the larynx/oropharynx aiming to achieve a cure with organ preservation. Human papillomavirus infection for oropharyngeal SCC is not tested in some Asian countries and there is still no consensus to treat p16-positive cases differently from p16-negative. Recommendations for larynx preservation vary according to facilities in each country, however, individualized choice is emphasized. Inequality across countries/continents is evident, with a similar pattern of recommendations among developed as well as developing ones. No CPGs were found in Latin America as well as Oceania countries, where the incidence of HNC is high and limitations of access to treatment may be encountered.https://www.mdpi.com/2072-6694/15/17/4405cancer treatmentguidelineshead and neck cancerlarynx canceroral canceroropharynx cancer |
| spellingShingle | Lady Paola Aristizabal Arboleda Genival Barbosa de Carvalho Alan Roger Santos-Silva Gisele Aparecida Fernandes Jose Guilherme Vartanian David I. Conway Shama Virani Paul Brennan Luiz Paulo Kowalski Maria Paula Curado Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines Worldwide Cancers cancer treatment guidelines head and neck cancer larynx cancer oral cancer oropharynx cancer |
| title | Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines Worldwide |
| title_full | Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines Worldwide |
| title_fullStr | Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines Worldwide |
| title_full_unstemmed | Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines Worldwide |
| title_short | Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines Worldwide |
| title_sort | squamous cell carcinoma of the oral cavity oropharynx and larynx a scoping review of treatment guidelines worldwide |
| topic | cancer treatment guidelines head and neck cancer larynx cancer oral cancer oropharynx cancer |
| url | https://www.mdpi.com/2072-6694/15/17/4405 |
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