Systemic β-Adrenergic Receptor Activation Augments the ex vivo Expansion and Anti-Tumor Activity of Vγ9Vδ2 T-Cells

Systemic β-Adrenergic Receptor Activation Augments the ex vivo Expansion and Anti-Tumor Activity of Vγ9Vδ2 T-Cells

TCR-gamma delta (γδ) T-cells are considered important players in the graft-vs.-tumor effect following allogeneic hematopoietic cell transplantation (alloHCT) and have emerged as candidates for adoptive transfer immunotherapy in the treatment of both solid and hematological tumors. Systemic β-adrener...

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Bibliographic Details
Main Authors: Forrest L. Baker, Austin B. Bigley, Nadia H. Agha, Charles R. Pedlar, Daniel P. O'Connor, Richard A. Bond, Catherine M. Bollard, Emmanuel Katsanis, Richard J. Simpson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
exercise immunology
beta-blockers
gamma-delta t-cells
exercise
adoptive transfer immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03082/full

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