Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract
The present study was carried out to evaluate the cerebroprotective effect of the aqueous extract of the roots of Glycyrrhiza glabra Linn. (250 and 500 mg/kg) in hypoxic rats. Hypoxia was induced by providing sodium nitrite drinking water to rats for 14 days. Extract at the tested doses promoted the...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bangladesh Pharmacological Society
2009-06-01
|
| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | http://www.bdjpharmacol.com/0401/60.pdf |
| _version_ | 1818172180559560704 |
|---|---|
| author | P. Muralidharan G. Balamurugan Venu Babu |
| author_facet | P. Muralidharan G. Balamurugan Venu Babu |
| author_sort | P. Muralidharan |
| collection | DOAJ |
| description | The present study was carried out to evaluate the cerebroprotective effect of the aqueous extract of the roots of Glycyrrhiza glabra Linn. (250 and 500 mg/kg) in hypoxic rats. Hypoxia was induced by providing sodium nitrite drinking water to rats for 14 days. Extract at the tested doses promoted the locomotor activity and spatial behavior significantly, which was impaired in hypoxic rats. The extract administration restored the decreased levels of brain enzymes such as glutamate and dopamine and decreased acetylcholinesterase (AchE) activity significantly. Levels of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase were reduced due to hypoxia and were restored to near normalcy by administration of ethanol extract of G. glabra. Increased lipid peroxidation in hypoxic rats was also restored significantly by extract treatment. Thus, this study suggests that ethanol extract of G. glabra possess a cerebroprotective effect in hypoxic rats, which may be mediated by its antioxidant effects. |
| first_indexed | 2024-12-11T19:08:31Z |
| format | Article |
| id | doaj.art-f17f8fca76f54435b19c628dd97b8b9c |
| institution | Directory Open Access Journal |
| issn | 1991-007X 1991-0088 |
| language | English |
| last_indexed | 2024-12-11T19:08:31Z |
| publishDate | 2009-06-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-f17f8fca76f54435b19c628dd97b8b9c2022-12-22T00:53:51ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-007X1991-00882009-06-01416064Cerebroprotective effect of Glycyrrhiza glabra Linn. root extractP. MuralidharanG. BalamuruganVenu BabuThe present study was carried out to evaluate the cerebroprotective effect of the aqueous extract of the roots of Glycyrrhiza glabra Linn. (250 and 500 mg/kg) in hypoxic rats. Hypoxia was induced by providing sodium nitrite drinking water to rats for 14 days. Extract at the tested doses promoted the locomotor activity and spatial behavior significantly, which was impaired in hypoxic rats. The extract administration restored the decreased levels of brain enzymes such as glutamate and dopamine and decreased acetylcholinesterase (AchE) activity significantly. Levels of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase were reduced due to hypoxia and were restored to near normalcy by administration of ethanol extract of G. glabra. Increased lipid peroxidation in hypoxic rats was also restored significantly by extract treatment. Thus, this study suggests that ethanol extract of G. glabra possess a cerebroprotective effect in hypoxic rats, which may be mediated by its antioxidant effects.http://www.bdjpharmacol.com/0401/60.pdfCerebroprotectiveGlycyrrhiza glabraHypoxicRat |
| spellingShingle | P. Muralidharan G. Balamurugan Venu Babu Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract Bangladesh Journal of Pharmacology Cerebroprotective Glycyrrhiza glabra Hypoxic Rat |
| title | Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract |
| title_full | Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract |
| title_fullStr | Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract |
| title_full_unstemmed | Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract |
| title_short | Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract |
| title_sort | cerebroprotective effect of glycyrrhiza glabra linn root extract |
| topic | Cerebroprotective Glycyrrhiza glabra Hypoxic Rat |
| url | http://www.bdjpharmacol.com/0401/60.pdf |
| work_keys_str_mv | AT pmuralidharan cerebroprotectiveeffectofglycyrrhizaglabralinnrootextract AT gbalamurugan cerebroprotectiveeffectofglycyrrhizaglabralinnrootextract AT venubabu cerebroprotectiveeffectofglycyrrhizaglabralinnrootextract |