Oncolytic Vaccinia Virus Harboring <i>Aphrocallistes vastus</i> Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3
<i>Aphrocallistes vastus</i> lectin (AVL) is a C-type marine lectin produced by sponges. Our previous study demonstrated that genes encoding AVL enhanced the cytotoxic effect of oncolytic vaccinia virus (oncoVV) in a variety of cancer cells. In this study, the inhibitory effect of oncoVV...
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MDPI AG
2021-09-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/19/10/532 |
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| author | Jiajun Ni Hualin Feng Xiang Xu Tingting Liu Ting Ye Kan Chen Gongchu Li |
| author_facet | Jiajun Ni Hualin Feng Xiang Xu Tingting Liu Ting Ye Kan Chen Gongchu Li |
| author_sort | Jiajun Ni |
| collection | DOAJ |
| description | <i>Aphrocallistes vastus</i> lectin (AVL) is a C-type marine lectin produced by sponges. Our previous study demonstrated that genes encoding AVL enhanced the cytotoxic effect of oncolytic vaccinia virus (oncoVV) in a variety of cancer cells. In this study, the inhibitory effect of oncoVV-AVL on Hela S3 cervical cancer cells, a cell line with spheroidizing ability, was explored. The results showed that oncoVV-AVL could inhibit Hela S3 cells growth both in vivo and in vitro. Further investigation revealed that AVL increased the virus replication, promote the expression of OASL protein and stimulated the activation of Raf in Hela S3 cells. This study may provide insight into a novel way for the utilization of lection AVL. |
| first_indexed | 2024-03-10T06:26:29Z |
| format | Article |
| id | doaj.art-f18151b9f27c423588fd170d5c6ed2fa |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T06:26:29Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-f18151b9f27c423588fd170d5c6ed2fa2023-11-22T18:54:55ZengMDPI AGMarine Drugs1660-33972021-09-01191053210.3390/md19100532Oncolytic Vaccinia Virus Harboring <i>Aphrocallistes vastus</i> Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3Jiajun Ni0Hualin Feng1Xiang Xu2Tingting Liu3Ting Ye4Kan Chen5Gongchu Li6College of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, China<i>Aphrocallistes vastus</i> lectin (AVL) is a C-type marine lectin produced by sponges. Our previous study demonstrated that genes encoding AVL enhanced the cytotoxic effect of oncolytic vaccinia virus (oncoVV) in a variety of cancer cells. In this study, the inhibitory effect of oncoVV-AVL on Hela S3 cervical cancer cells, a cell line with spheroidizing ability, was explored. The results showed that oncoVV-AVL could inhibit Hela S3 cells growth both in vivo and in vitro. Further investigation revealed that AVL increased the virus replication, promote the expression of OASL protein and stimulated the activation of Raf in Hela S3 cells. This study may provide insight into a novel way for the utilization of lection AVL.https://www.mdpi.com/1660-3397/19/10/532<i>Aphrocallistes vastus</i> lectinsphere formation assayoncolytic vaccinia virusHela S3 cell line |
| spellingShingle | Jiajun Ni Hualin Feng Xiang Xu Tingting Liu Ting Ye Kan Chen Gongchu Li Oncolytic Vaccinia Virus Harboring <i>Aphrocallistes vastus</i> Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3 Marine Drugs <i>Aphrocallistes vastus</i> lectin sphere formation assay oncolytic vaccinia virus Hela S3 cell line |
| title | Oncolytic Vaccinia Virus Harboring <i>Aphrocallistes vastus</i> Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3 |
| title_full | Oncolytic Vaccinia Virus Harboring <i>Aphrocallistes vastus</i> Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3 |
| title_fullStr | Oncolytic Vaccinia Virus Harboring <i>Aphrocallistes vastus</i> Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3 |
| title_full_unstemmed | Oncolytic Vaccinia Virus Harboring <i>Aphrocallistes vastus</i> Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3 |
| title_short | Oncolytic Vaccinia Virus Harboring <i>Aphrocallistes vastus</i> Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3 |
| title_sort | oncolytic vaccinia virus harboring i aphrocallistes vastus i lectin inhibits the growth of cervical cancer cells hela s3 |
| topic | <i>Aphrocallistes vastus</i> lectin sphere formation assay oncolytic vaccinia virus Hela S3 cell line |
| url | https://www.mdpi.com/1660-3397/19/10/532 |
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