Correlation analysis between smoke exposure and serum neurofilament light chain in adults: a cross-sectional study
Abstract Background Smoke exposure is a prevalent and well-documented risk factor for various diseases across different organ systems. Serum neurofilament light chain (sNfL) has emerged as a promising biomarker for a multitude of nervous system disorders. However, there is a notable paucity of resea...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-024-17811-8 |
| _version_ | 1827325931057840128 |
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| author | Ning Zhu Jing Zhu Shanhong Lin Hang Yu Chao Cao |
| author_facet | Ning Zhu Jing Zhu Shanhong Lin Hang Yu Chao Cao |
| author_sort | Ning Zhu |
| collection | DOAJ |
| description | Abstract Background Smoke exposure is a prevalent and well-documented risk factor for various diseases across different organ systems. Serum neurofilament light chain (sNfL) has emerged as a promising biomarker for a multitude of nervous system disorders. However, there is a notable paucity of research exploring the associations between smoke exposure and sNfL levels. Methods We conducted a comprehensive analysis of the National Health and Nutrition Examination Survey (NHANES) cross-sectional data spanning the years 2013 to 2014. Serum cotinine levels were classified into the following three groups: < 0.05, 0.05–2.99, and ≥ 3 ng/ml. Multiple linear regression models were employed to assess the relationships between serum cotinine levels and sNfL levels. Additionally, we utilized restricted cubic spline analyses to elucidate the potential nonlinear relationship between serum cotinine and sNfL levels. Results A total of 2053 participants were included in our present research. Among these individuals, the mean age was 47.04 ± 15.32 years, and males accounted for 48.2% of the total study population. After adjusting the full model, serum cotinine was positively correlated with sNfl in the second group (β = 0.08, 95%CI 0.01–0.15) and in the highest concentration of serum cotinine (β = 0.10, 95%CI 0.01–0.19) compared to the group with the lowest serum cotinine concentrations. Current smokers, in comparison to non-smokers, exhibited a trend toward elevated sNfL levels (β = 0.07, 95%CI 0.01–0.13). Furthermore, subgroup analyses revealed interactions between serum cotinine levels and different age groups (P for interaction = 0.001) and gender stratification (P for interaction = 0.015) on sNfL levels. Conclusion The study suggested that serum cotinine was significantly and positively associated with sNfl levels in adult participants. Furthermore, current smokers tend to exhibit elevated sNfL levels. This research sheds light on the potential implications of smoke exposure on neurological function impairment and underscores the importance of further exploration in this area. |
| first_indexed | 2024-03-07T14:36:22Z |
| format | Article |
| id | doaj.art-f185082b367141d5af8dcc412626b3b4 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-03-07T14:36:22Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-f185082b367141d5af8dcc412626b3b42024-03-05T20:37:45ZengBMCBMC Public Health1471-24582024-02-0124111110.1186/s12889-024-17811-8Correlation analysis between smoke exposure and serum neurofilament light chain in adults: a cross-sectional studyNing Zhu0Jing Zhu1Shanhong Lin2Hang Yu3Chao Cao4Department of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Ningbo, The First Affiliated Hospital of Ningbo UniversityDepartment of Cardiology, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)Department of Ultrasound, The First Affiliated Hospital of Ningbo UniversityDepartment of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Ningbo, The First Affiliated Hospital of Ningbo UniversityDepartment of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Ningbo, The First Affiliated Hospital of Ningbo UniversityAbstract Background Smoke exposure is a prevalent and well-documented risk factor for various diseases across different organ systems. Serum neurofilament light chain (sNfL) has emerged as a promising biomarker for a multitude of nervous system disorders. However, there is a notable paucity of research exploring the associations between smoke exposure and sNfL levels. Methods We conducted a comprehensive analysis of the National Health and Nutrition Examination Survey (NHANES) cross-sectional data spanning the years 2013 to 2014. Serum cotinine levels were classified into the following three groups: < 0.05, 0.05–2.99, and ≥ 3 ng/ml. Multiple linear regression models were employed to assess the relationships between serum cotinine levels and sNfL levels. Additionally, we utilized restricted cubic spline analyses to elucidate the potential nonlinear relationship between serum cotinine and sNfL levels. Results A total of 2053 participants were included in our present research. Among these individuals, the mean age was 47.04 ± 15.32 years, and males accounted for 48.2% of the total study population. After adjusting the full model, serum cotinine was positively correlated with sNfl in the second group (β = 0.08, 95%CI 0.01–0.15) and in the highest concentration of serum cotinine (β = 0.10, 95%CI 0.01–0.19) compared to the group with the lowest serum cotinine concentrations. Current smokers, in comparison to non-smokers, exhibited a trend toward elevated sNfL levels (β = 0.07, 95%CI 0.01–0.13). Furthermore, subgroup analyses revealed interactions between serum cotinine levels and different age groups (P for interaction = 0.001) and gender stratification (P for interaction = 0.015) on sNfL levels. Conclusion The study suggested that serum cotinine was significantly and positively associated with sNfl levels in adult participants. Furthermore, current smokers tend to exhibit elevated sNfL levels. This research sheds light on the potential implications of smoke exposure on neurological function impairment and underscores the importance of further exploration in this area.https://doi.org/10.1186/s12889-024-17811-8Smoke exposureSerum cotinineSerum neurofilament light chainNeurological functionNHANES |
| spellingShingle | Ning Zhu Jing Zhu Shanhong Lin Hang Yu Chao Cao Correlation analysis between smoke exposure and serum neurofilament light chain in adults: a cross-sectional study BMC Public Health Smoke exposure Serum cotinine Serum neurofilament light chain Neurological function NHANES |
| title | Correlation analysis between smoke exposure and serum neurofilament light chain in adults: a cross-sectional study |
| title_full | Correlation analysis between smoke exposure and serum neurofilament light chain in adults: a cross-sectional study |
| title_fullStr | Correlation analysis between smoke exposure and serum neurofilament light chain in adults: a cross-sectional study |
| title_full_unstemmed | Correlation analysis between smoke exposure and serum neurofilament light chain in adults: a cross-sectional study |
| title_short | Correlation analysis between smoke exposure and serum neurofilament light chain in adults: a cross-sectional study |
| title_sort | correlation analysis between smoke exposure and serum neurofilament light chain in adults a cross sectional study |
| topic | Smoke exposure Serum cotinine Serum neurofilament light chain Neurological function NHANES |
| url | https://doi.org/10.1186/s12889-024-17811-8 |
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