Oxidative stress in male infertility and therapeutic approach: A mini-review
Growing evidence suggests that oxidative stress is a major cause of male infertility. Spermatozoa are highly sensitive cells due to the vulnerability of their membrane fatty acids and the diminished antioxidant defense. Reactive oxygen species (ROS) impact multiple signaling pathways involved in mit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Asian Pacific Journal of Reproduction |
| Subjects: | |
| Online Access: | http://www.apjr.net/article.asp?issn=2305-0500;year=2023;volume=12;issue=6;spage=249;epage=255;aulast=Lahimer |
| _version_ | 1827270404446617600 |
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| author | Marwa Lahimer Henda Mustapha Véronique Bach Hafida Khorsi-Cauet Moncef Benkhalifa Mounir Ajina Habib Ben Ali |
| author_facet | Marwa Lahimer Henda Mustapha Véronique Bach Hafida Khorsi-Cauet Moncef Benkhalifa Mounir Ajina Habib Ben Ali |
| author_sort | Marwa Lahimer |
| collection | DOAJ |
| description | Growing evidence suggests that oxidative stress is a major cause of male infertility. Spermatozoa are highly sensitive cells due to the vulnerability of their membrane fatty acids and the diminished antioxidant defense. Reactive oxygen species (ROS) impact multiple signaling pathways involved in mitochondrial dysfunction, hormonal unbalance and semen quality decline. The origin of ROS is diverse, including generated normal cellular metabolism, environmental exposure, advanced paternal age and inflammation. Research has indicated that antioxidant supplementation can improve oxidative stress and reduce the risk of chronic diseases. Moreover, it is widely known that antioxidant supplementation can enhance sperm quality and increase the pregnancy rate in couples undergoing fertility treatments. The current study highlights the deleterious effect of ROS and its impact on semen function. In addition, it contributes to the development of a clinical approach for the use of antioxidants in the management of male infertility. |
| first_indexed | 2024-03-08T13:13:52Z |
| format | Article |
| id | doaj.art-f1858551469e45ca9c7c4a11df928919 |
| institution | Directory Open Access Journal |
| issn | 2305-0500 2305-0519 |
| language | English |
| last_indexed | 2025-03-22T05:20:53Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Reproduction |
| spelling | doaj.art-f1858551469e45ca9c7c4a11df9289192024-04-27T03:49:48ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Reproduction2305-05002305-05192023-01-0112624925510.4103/2305-0500.390299Oxidative stress in male infertility and therapeutic approach: A mini-reviewMarwa LahimerHenda MustaphaVéronique BachHafida Khorsi-CauetMoncef BenkhalifaMounir AjinaHabib Ben AliGrowing evidence suggests that oxidative stress is a major cause of male infertility. Spermatozoa are highly sensitive cells due to the vulnerability of their membrane fatty acids and the diminished antioxidant defense. Reactive oxygen species (ROS) impact multiple signaling pathways involved in mitochondrial dysfunction, hormonal unbalance and semen quality decline. The origin of ROS is diverse, including generated normal cellular metabolism, environmental exposure, advanced paternal age and inflammation. Research has indicated that antioxidant supplementation can improve oxidative stress and reduce the risk of chronic diseases. Moreover, it is widely known that antioxidant supplementation can enhance sperm quality and increase the pregnancy rate in couples undergoing fertility treatments. The current study highlights the deleterious effect of ROS and its impact on semen function. In addition, it contributes to the development of a clinical approach for the use of antioxidants in the management of male infertility.http://www.apjr.net/article.asp?issn=2305-0500;year=2023;volume=12;issue=6;spage=249;epage=255;aulast=Lahimeroxidative stress; reactive oxygen species; mitochondria; antioxidant supplementation; spermatozoa |
| spellingShingle | Marwa Lahimer Henda Mustapha Véronique Bach Hafida Khorsi-Cauet Moncef Benkhalifa Mounir Ajina Habib Ben Ali Oxidative stress in male infertility and therapeutic approach: A mini-review Asian Pacific Journal of Reproduction oxidative stress; reactive oxygen species; mitochondria; antioxidant supplementation; spermatozoa |
| title | Oxidative stress in male infertility and therapeutic approach: A mini-review |
| title_full | Oxidative stress in male infertility and therapeutic approach: A mini-review |
| title_fullStr | Oxidative stress in male infertility and therapeutic approach: A mini-review |
| title_full_unstemmed | Oxidative stress in male infertility and therapeutic approach: A mini-review |
| title_short | Oxidative stress in male infertility and therapeutic approach: A mini-review |
| title_sort | oxidative stress in male infertility and therapeutic approach a mini review |
| topic | oxidative stress; reactive oxygen species; mitochondria; antioxidant supplementation; spermatozoa |
| url | http://www.apjr.net/article.asp?issn=2305-0500;year=2023;volume=12;issue=6;spage=249;epage=255;aulast=Lahimer |
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