Predicting the site of distant metastases in breast cancer
Background. Distant organ tumor dissemination is a major cause of breast cancer-related deaths. Breast cancer can metastasize to several organs, and the most frequent metastatic sites include the bones, lungs and liver. There is a question what factors can influence the direction of spread of tumor...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2023-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/2441 |
| _version_ | 1797875762423922688 |
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| author | E. S. Grigoryeva E. E. Ivanyuk E. L. Choinzonov N. V. Cherdyntseva |
| author_facet | E. S. Grigoryeva E. E. Ivanyuk E. L. Choinzonov N. V. Cherdyntseva |
| author_sort | E. S. Grigoryeva |
| collection | DOAJ |
| description | Background. Distant organ tumor dissemination is a major cause of breast cancer-related deaths. Breast cancer can metastasize to several organs, and the most frequent metastatic sites include the bones, lungs and liver. There is a question what factors can influence the direction of spread of tumor cells to a particular organ.Material and Methods. We summarized the data available in the world literature on methods for prediction of the localization of distant metastases in breast cancer patients.Results. We divided the factors associated with the localization of distant metastases into two main groups: clinicopathological parameters of breast cancer patients and molecular features of tumor microenvironment and tumor cells (primary tumor and circulating tumor cells) or its derivates – exosomes. From our point of view, the most powerful clinicopathological factor predicting the distant metastasis site is a molecular subtype of primary tumor. We can conclude that luminal (HR+/HER2-) tumors are often characterized by single metastases and bones are the most common metastatic site, while TNBC and HER2-enriched tumors often metastasize to multiple sites, most commonly brain and liver. However, several authors did not reveal these associations in their studies. It likely indicates the existence of other factors that significantly affect the organotropism of metastasis. Numerous studies demonstrate the association of different molecules expressed on tumor cells with organotropic metastasis. However, these data are very fragmentary and rather contradictory.Conclusion. The found associations are common to all participants of metastatic cascade, but remains unclear which factors are essential and crucial in determining the direction of metastasis. |
| first_indexed | 2024-04-10T01:51:40Z |
| format | Article |
| id | doaj.art-f185c7e628244299baaa1e14b76cf1d7 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:51:40Z |
| publishDate | 2023-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-f185c7e628244299baaa1e14b76cf1d72023-03-13T09:05:56ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682023-02-0122115115810.21294/1814-4861-2023-22-1-151-1581095Predicting the site of distant metastases in breast cancerE. S. Grigoryeva0E. E. Ivanyuk1E. L. Choinzonov2N. V. Cherdyntseva3Научно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наукНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наукНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наукНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наукBackground. Distant organ tumor dissemination is a major cause of breast cancer-related deaths. Breast cancer can metastasize to several organs, and the most frequent metastatic sites include the bones, lungs and liver. There is a question what factors can influence the direction of spread of tumor cells to a particular organ.Material and Methods. We summarized the data available in the world literature on methods for prediction of the localization of distant metastases in breast cancer patients.Results. We divided the factors associated with the localization of distant metastases into two main groups: clinicopathological parameters of breast cancer patients and molecular features of tumor microenvironment and tumor cells (primary tumor and circulating tumor cells) or its derivates – exosomes. From our point of view, the most powerful clinicopathological factor predicting the distant metastasis site is a molecular subtype of primary tumor. We can conclude that luminal (HR+/HER2-) tumors are often characterized by single metastases and bones are the most common metastatic site, while TNBC and HER2-enriched tumors often metastasize to multiple sites, most commonly brain and liver. However, several authors did not reveal these associations in their studies. It likely indicates the existence of other factors that significantly affect the organotropism of metastasis. Numerous studies demonstrate the association of different molecules expressed on tumor cells with organotropic metastasis. However, these data are very fragmentary and rather contradictory.Conclusion. The found associations are common to all participants of metastatic cascade, but remains unclear which factors are essential and crucial in determining the direction of metastasis.https://www.siboncoj.ru/jour/article/view/2441рак молочной железыгематогенное метастазированиепредикторы прогноза |
| spellingShingle | E. S. Grigoryeva E. E. Ivanyuk E. L. Choinzonov N. V. Cherdyntseva Predicting the site of distant metastases in breast cancer Сибирский онкологический журнал рак молочной железы гематогенное метастазирование предикторы прогноза |
| title | Predicting the site of distant metastases in breast cancer |
| title_full | Predicting the site of distant metastases in breast cancer |
| title_fullStr | Predicting the site of distant metastases in breast cancer |
| title_full_unstemmed | Predicting the site of distant metastases in breast cancer |
| title_short | Predicting the site of distant metastases in breast cancer |
| title_sort | predicting the site of distant metastases in breast cancer |
| topic | рак молочной железы гематогенное метастазирование предикторы прогноза |
| url | https://www.siboncoj.ru/jour/article/view/2441 |
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