Rare variants increase the risk of severe COVID-19
Evidence is mounting that rare loss-of-function variants in the TLR7 gene predispose men with no medical history to severe forms of COVID-19.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2021-03-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/67860 |
| _version_ | 1811227589505712128 |
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| author | Frank L van de Veerdonk Mihai G Netea |
| author_facet | Frank L van de Veerdonk Mihai G Netea |
| author_sort | Frank L van de Veerdonk |
| collection | DOAJ |
| description | Evidence is mounting that rare loss-of-function variants in the TLR7 gene predispose men with no medical history to severe forms of COVID-19. |
| first_indexed | 2024-04-12T09:44:56Z |
| format | Article |
| id | doaj.art-f186512ab00b455799f0f3bc8079af52 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:44:56Z |
| publishDate | 2021-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-f186512ab00b455799f0f3bc8079af522022-12-22T03:37:59ZengeLife Sciences Publications LtdeLife2050-084X2021-03-011010.7554/eLife.67860Rare variants increase the risk of severe COVID-19Frank L van de Veerdonk0https://orcid.org/0000-0002-1121-4894Mihai G Netea1Department of Internal Medicine, Radboudumc Center for Infectious Diseases, Nijmegen, NetherlandsDepartment of Internal Medicine, Radboudumc Center for Infectious Diseases, Nijmegen, Netherlands; Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, GermanyEvidence is mounting that rare loss-of-function variants in the TLR7 gene predispose men with no medical history to severe forms of COVID-19.https://elifesciences.org/articles/67860TLR7COVID-19LASSO logistic regression analysis |
| spellingShingle | Frank L van de Veerdonk Mihai G Netea Rare variants increase the risk of severe COVID-19 eLife TLR7 COVID-19 LASSO logistic regression analysis |
| title | Rare variants increase the risk of severe COVID-19 |
| title_full | Rare variants increase the risk of severe COVID-19 |
| title_fullStr | Rare variants increase the risk of severe COVID-19 |
| title_full_unstemmed | Rare variants increase the risk of severe COVID-19 |
| title_short | Rare variants increase the risk of severe COVID-19 |
| title_sort | rare variants increase the risk of severe covid 19 |
| topic | TLR7 COVID-19 LASSO logistic regression analysis |
| url | https://elifesciences.org/articles/67860 |
| work_keys_str_mv | AT franklvandeveerdonk rarevariantsincreasetheriskofseverecovid19 AT mihaignetea rarevariantsincreasetheriskofseverecovid19 |