Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System
Introduction: The diagnosis of Tuberculous Meningitis (TBM) has remained a challenge due to its insidious onset and the failure of conventional diagnostic tests. The present study aimed to identify the mycobacterial pathogen in the CSF of patients with TBM and a poor prognosis. Methods: We retrospec...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2020-09-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/article-1-874-en.html |
| _version_ | 1797280550165151744 |
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| author | Prachi R. Bapat Seema D. Shekhawat Aliabbas A. Husain Renuka S. Dodkey Hatim F. Daginawala Lokendra K. Singh Rajpal S. Kashyap |
| author_facet | Prachi R. Bapat Seema D. Shekhawat Aliabbas A. Husain Renuka S. Dodkey Hatim F. Daginawala Lokendra K. Singh Rajpal S. Kashyap |
| author_sort | Prachi R. Bapat |
| collection | DOAJ |
| description | Introduction: The diagnosis of Tuberculous Meningitis (TBM) has remained a challenge due to its insidious onset and the failure of conventional diagnostic tests. The present study aimed to identify the mycobacterial pathogen in the CSF of patients with TBM and a poor prognosis.
Methods: We retrospectively recruited 224 TBM and 34 non-TBM patients admitted to the Central India Institute of Medical Sciences, Nagpur, India, in 2014. The CSF samples of these patients were subjected to a duplex PCR assay for the species-specific identification of the causative pathogen.
Results: M. bovis and infection with M.tuberculosis were detected in 7% (18) and 32.9% (85) of the patients, respectively. Moreover, 14% (36) of the study samples were culture positive; however, the mycobacterial pathogens could not be differentiated to the species level.
Conclusion: The present study findings emphasized the potentially vital importance of M. bovis identification for appropriate patient management. The obtained data also demonstrated the persistent significance of M. bovis, as a zoonotic pathogen. |
| first_indexed | 2024-03-07T16:42:48Z |
| format | Article |
| id | doaj.art-f1871099089b47a98fe03b3aace972aa |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:42:48Z |
| publishDate | 2020-09-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-f1871099089b47a98fe03b3aace972aa2024-03-03T07:47:27ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422020-09-01115619630Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous SystemPrachi R. Bapat0Seema D. Shekhawat1Aliabbas A. Husain2Renuka S. Dodkey3Hatim F. Daginawala4Lokendra K. Singh5Rajpal S. Kashyap6 Research Centre, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India. Research Centre, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India. Research Centre, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India. Research Centre, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India. Research Centre, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India. Research Centre, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India. Research Centre, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India. Introduction: The diagnosis of Tuberculous Meningitis (TBM) has remained a challenge due to its insidious onset and the failure of conventional diagnostic tests. The present study aimed to identify the mycobacterial pathogen in the CSF of patients with TBM and a poor prognosis. Methods: We retrospectively recruited 224 TBM and 34 non-TBM patients admitted to the Central India Institute of Medical Sciences, Nagpur, India, in 2014. The CSF samples of these patients were subjected to a duplex PCR assay for the species-specific identification of the causative pathogen. Results: M. bovis and infection with M.tuberculosis were detected in 7% (18) and 32.9% (85) of the patients, respectively. Moreover, 14% (36) of the study samples were culture positive; however, the mycobacterial pathogens could not be differentiated to the species level. Conclusion: The present study findings emphasized the potentially vital importance of M. bovis identification for appropriate patient management. The obtained data also demonstrated the persistent significance of M. bovis, as a zoonotic pathogen.http://bcn.iums.ac.ir/article-1-874-en.htmlduplex pcrmycobacterium bovistuberculous meningitiszoonoses |
| spellingShingle | Prachi R. Bapat Seema D. Shekhawat Aliabbas A. Husain Renuka S. Dodkey Hatim F. Daginawala Lokendra K. Singh Rajpal S. Kashyap Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System Basic and Clinical Neuroscience duplex pcr mycobacterium bovis tuberculous meningitis zoonoses |
| title | Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System |
| title_full | Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System |
| title_fullStr | Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System |
| title_full_unstemmed | Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System |
| title_short | Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System |
| title_sort | diagnostic challenges and prospects associated with zoonotic tuberculosis of central nervous system |
| topic | duplex pcr mycobacterium bovis tuberculous meningitis zoonoses |
| url | http://bcn.iums.ac.ir/article-1-874-en.html |
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