Porcine skin ablation using mid-infrared picosecond pulse burst
We present the porcine skin ablation using a mid-infrared high-repetition-rate picosecond pulse burst laser. A burst-mode pulse with a repetition rate of 16.32 MHz was generated from a home-built difference frequency generation (DFG) system operating at 3 μm. Within each burst, there were 16 equally...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | Results in Optics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666950122000980 |
| _version_ | 1828123239837073408 |
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| author | Wenjie Yue Yongchang Zhang Libing Shi Tao Chen Jianmin Chen Bo Wu Songying Zhang Rong Shu Yonghang Shen |
| author_facet | Wenjie Yue Yongchang Zhang Libing Shi Tao Chen Jianmin Chen Bo Wu Songying Zhang Rong Shu Yonghang Shen |
| author_sort | Wenjie Yue |
| collection | DOAJ |
| description | We present the porcine skin ablation using a mid-infrared high-repetition-rate picosecond pulse burst laser. A burst-mode pulse with a repetition rate of 16.32 MHz was generated from a home-built difference frequency generation (DFG) system operating at 3 μm. Within each burst, there were 16 equally spaced 8.5 ps sub-pulses at an intra-burst repetition rate of ∼3.3 GHz. To study the laser-tissue interaction, laser powers of 1 to 2 W, and scanning times from 1 to 10 with spot size of ∼50 μm were applied to irradiate the fresh porcine skin. The results demonstrate that the burst-mode pulse with modest peak power density of MW/cm2 is efficient for tissue ablation. The optimized ablation depth increased with the average power and scanning times, reaching a maximal incision depth of 150 μm. Thanks to the high repetition rate of intra-burst pulse and high absorption of radiation, the ablation width and thermal effect width kept within 50 μm and 25 μm in all control groups. It is believed that as the first demonstration, such mid-infrared burst-mode laser radiation with modest power intensity is of great potential to realize micron penetration depth and low thermal effect in high-precision surgery applications. |
| first_indexed | 2024-04-11T14:47:41Z |
| format | Article |
| id | doaj.art-f187315e0e3343b4bcb5089bb21178db |
| institution | Directory Open Access Journal |
| issn | 2666-9501 |
| language | English |
| last_indexed | 2024-04-11T14:47:41Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Optics |
| spelling | doaj.art-f187315e0e3343b4bcb5089bb21178db2022-12-22T04:17:34ZengElsevierResults in Optics2666-95012022-12-019100309Porcine skin ablation using mid-infrared picosecond pulse burstWenjie Yue0Yongchang Zhang1Libing Shi2Tao Chen3Jianmin Chen4Bo Wu5Songying Zhang6Rong Shu7Yonghang Shen8Key Laboratory of Space Active Opto-Electronics Technology, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China; State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaState Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaKey Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, ChinaKey Laboratory of Space Active Opto-Electronics Technology, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, ChinaKey Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, ChinaState Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaState Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaKey Laboratory of Space Active Opto-Electronics Technology, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China; Corresponding authors.State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China; Corresponding authors.We present the porcine skin ablation using a mid-infrared high-repetition-rate picosecond pulse burst laser. A burst-mode pulse with a repetition rate of 16.32 MHz was generated from a home-built difference frequency generation (DFG) system operating at 3 μm. Within each burst, there were 16 equally spaced 8.5 ps sub-pulses at an intra-burst repetition rate of ∼3.3 GHz. To study the laser-tissue interaction, laser powers of 1 to 2 W, and scanning times from 1 to 10 with spot size of ∼50 μm were applied to irradiate the fresh porcine skin. The results demonstrate that the burst-mode pulse with modest peak power density of MW/cm2 is efficient for tissue ablation. The optimized ablation depth increased with the average power and scanning times, reaching a maximal incision depth of 150 μm. Thanks to the high repetition rate of intra-burst pulse and high absorption of radiation, the ablation width and thermal effect width kept within 50 μm and 25 μm in all control groups. It is believed that as the first demonstration, such mid-infrared burst-mode laser radiation with modest power intensity is of great potential to realize micron penetration depth and low thermal effect in high-precision surgery applications.http://www.sciencedirect.com/science/article/pii/S2666950122000980Mid-infraredPicosecond pulse burstDifference frequency generationTissue ablation |
| spellingShingle | Wenjie Yue Yongchang Zhang Libing Shi Tao Chen Jianmin Chen Bo Wu Songying Zhang Rong Shu Yonghang Shen Porcine skin ablation using mid-infrared picosecond pulse burst Results in Optics Mid-infrared Picosecond pulse burst Difference frequency generation Tissue ablation |
| title | Porcine skin ablation using mid-infrared picosecond pulse burst |
| title_full | Porcine skin ablation using mid-infrared picosecond pulse burst |
| title_fullStr | Porcine skin ablation using mid-infrared picosecond pulse burst |
| title_full_unstemmed | Porcine skin ablation using mid-infrared picosecond pulse burst |
| title_short | Porcine skin ablation using mid-infrared picosecond pulse burst |
| title_sort | porcine skin ablation using mid infrared picosecond pulse burst |
| topic | Mid-infrared Picosecond pulse burst Difference frequency generation Tissue ablation |
| url | http://www.sciencedirect.com/science/article/pii/S2666950122000980 |
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