Impairments in sleep and brain molecular clearance in people with cognitive deterioration and biological evidence of AD: a report of four cases

Impairments in sleep and brain molecular clearance in people with cognitive deterioration and biological evidence of AD: a report of four cases

Abstract Background Recent evidence suggests that the failure of the glymphatic system – the brain’s waste clearance system, which is active during sleep – plays a key role in the pathophysiology of Alzheimer’s Disease (AD). Glymphatic function can be investigated using serial MRIs after intrathecal...

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Bibliographic Details
Main Authors: Mariateresa Buongiorno, Esther Granell, Giovanni Caruana, Gemma Sansa, Yolanda Vives-Gilabert, Natalia Cullell, Jessica Molina-Seguin, Marta Almeria, Cristina Artero, Gonzalo Sánchez-Benavides, Nicola J Ray, Sonia A.L. Correa, Jerzy Krupinski
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Neurology
Subjects:
Glymphatic system
Polysomnography
Gadolinium-based contrast agent
Cognitive function
Obstructive sleep apnea
Prodromal AD
Online Access:https://doi.org/10.1186/s12883-023-03460-8

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