Differences in Histological Subtypes of Invasive Lobular Breast Carcinoma According to Immunohistochemical Molecular Classification
The technical complexity of gene expression profiling in routine practice has necessitated the use of surrogate molecular classification of breast cancer, based on immunohistochemical analyses. Background and objectives: The aim of this study was to compare the differences between histological and m...
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MDPI AG
2024-03-01
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| author | Ivan Ilić Jana Cvetković Ratko Ilić Ljubiša Cvetković Aleksandar Milićević Stefan Todorović Pavle Ranđelović |
| author_facet | Ivan Ilić Jana Cvetković Ratko Ilić Ljubiša Cvetković Aleksandar Milićević Stefan Todorović Pavle Ranđelović |
| author_sort | Ivan Ilić |
| collection | DOAJ |
| description | The technical complexity of gene expression profiling in routine practice has necessitated the use of surrogate molecular classification of breast cancer, based on immunohistochemical analyses. Background and objectives: The aim of this study was to compare the differences between histological and molecular subtypes of invasive lobular carcinoma (ILC) of the breast, in order to be able to predict the behavior and prognosis of the disease, as well as to effectively determine therapy. Material and Methods: This study included 263 cases of breast ILC diagnosed over a seven-year period. The diagnosis of invasive lobular carcinoma is based on the characteristic growth pattern and phenotype of cancer cells with the respective subtypes: classic, alveolar, solid, tubulolobular, pleomorphic and mixed lobular type. The examined cases were divided into five groups according to molecular classification based on the expression of ER, PR, HER2 and Ki67 immunohistochemical markers. Results: It was found that the pleomorphic subtype occurred statistically significantly less often as the luminal A subtype compared to others (<i>p</i> = 0.00027), and the HER2-enriched subtype occurred statistically significantly more often in the pT4 stage (<i>p</i> = 0.024). Conclusions: The results of this study significantly singled out the luminal A subtype, and among them classic ILC, as the subtype with the most favorable expression ratio of the investigated predictive/prognostic immunohistochemical markers. |
| first_indexed | 2024-04-24T18:24:05Z |
| format | Article |
| id | doaj.art-f18980d768104e9fa96c816d12e49728 |
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| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-24T18:24:05Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-f18980d768104e9fa96c816d12e497282024-03-27T13:33:28ZengMDPI AGDiagnostics2075-44182024-03-0114666010.3390/diagnostics14060660Differences in Histological Subtypes of Invasive Lobular Breast Carcinoma According to Immunohistochemical Molecular ClassificationIvan Ilić0Jana Cvetković1Ratko Ilić2Ljubiša Cvetković3Aleksandar Milićević4Stefan Todorović5Pavle Ranđelović6Center for Pathology and Pathological Anatomy, University Clinical Center Niš, Faculty of Medicine, University of Niš, 18000 Niš, SerbiaDepartment for Pathology, General Hospital Leskovac, 16000 Leskovac, SerbiaCenter for Pathology and Pathological Anatomy, University Clinical Center Niš, Faculty of Medicine, University of Niš, 18000 Niš, SerbiaDepartment for Pathology, General Hospital Leskovac, 16000 Leskovac, SerbiaCenter for Pathology and Pathological Anatomy, University Clinical Center Niš, Faculty of Medicine, University of Niš, 18000 Niš, SerbiaClinic of Neurology, University Clinical Center Niš, 18000 Niš, SerbiaDepartment of Physiology, Faculty of Medicine, University of Niš, 18000 Niš, SerbiaThe technical complexity of gene expression profiling in routine practice has necessitated the use of surrogate molecular classification of breast cancer, based on immunohistochemical analyses. Background and objectives: The aim of this study was to compare the differences between histological and molecular subtypes of invasive lobular carcinoma (ILC) of the breast, in order to be able to predict the behavior and prognosis of the disease, as well as to effectively determine therapy. Material and Methods: This study included 263 cases of breast ILC diagnosed over a seven-year period. The diagnosis of invasive lobular carcinoma is based on the characteristic growth pattern and phenotype of cancer cells with the respective subtypes: classic, alveolar, solid, tubulolobular, pleomorphic and mixed lobular type. The examined cases were divided into five groups according to molecular classification based on the expression of ER, PR, HER2 and Ki67 immunohistochemical markers. Results: It was found that the pleomorphic subtype occurred statistically significantly less often as the luminal A subtype compared to others (<i>p</i> = 0.00027), and the HER2-enriched subtype occurred statistically significantly more often in the pT4 stage (<i>p</i> = 0.024). Conclusions: The results of this study significantly singled out the luminal A subtype, and among them classic ILC, as the subtype with the most favorable expression ratio of the investigated predictive/prognostic immunohistochemical markers.https://www.mdpi.com/2075-4418/14/6/660invasive lobular carcinomaestrogen and progesterone receptorsimmunohistochemistrymolecular subtypestriple-negative breast cancer |
| spellingShingle | Ivan Ilić Jana Cvetković Ratko Ilić Ljubiša Cvetković Aleksandar Milićević Stefan Todorović Pavle Ranđelović Differences in Histological Subtypes of Invasive Lobular Breast Carcinoma According to Immunohistochemical Molecular Classification Diagnostics invasive lobular carcinoma estrogen and progesterone receptors immunohistochemistry molecular subtypes triple-negative breast cancer |
| title | Differences in Histological Subtypes of Invasive Lobular Breast Carcinoma According to Immunohistochemical Molecular Classification |
| title_full | Differences in Histological Subtypes of Invasive Lobular Breast Carcinoma According to Immunohistochemical Molecular Classification |
| title_fullStr | Differences in Histological Subtypes of Invasive Lobular Breast Carcinoma According to Immunohistochemical Molecular Classification |
| title_full_unstemmed | Differences in Histological Subtypes of Invasive Lobular Breast Carcinoma According to Immunohistochemical Molecular Classification |
| title_short | Differences in Histological Subtypes of Invasive Lobular Breast Carcinoma According to Immunohistochemical Molecular Classification |
| title_sort | differences in histological subtypes of invasive lobular breast carcinoma according to immunohistochemical molecular classification |
| topic | invasive lobular carcinoma estrogen and progesterone receptors immunohistochemistry molecular subtypes triple-negative breast cancer |
| url | https://www.mdpi.com/2075-4418/14/6/660 |
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