The Potential of Ameliorating COVID-19 and Sequelae From via Bioinformatics
The current coronavirus disease 2019 (COVID-19) outbreak is alarmingly escalating and raises challenges in finding efficient compounds for treatment. Repurposing phytochemicals in herbs is an ideal and economical approach for screening potential herbal components against COVID-19. Andrographis panic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-01-01
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| Series: | Bioinformatics and Biology Insights |
| Online Access: | https://doi.org/10.1177/11779322221149622 |
| _version_ | 1797954760198848512 |
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| author | Hien Thi Nguyen Van Mai Do Thanh Thuy Phan Dung Tam Nguyen Huynh |
| author_facet | Hien Thi Nguyen Van Mai Do Thanh Thuy Phan Dung Tam Nguyen Huynh |
| author_sort | Hien Thi Nguyen |
| collection | DOAJ |
| description | The current coronavirus disease 2019 (COVID-19) outbreak is alarmingly escalating and raises challenges in finding efficient compounds for treatment. Repurposing phytochemicals in herbs is an ideal and economical approach for screening potential herbal components against COVID-19. Andrographis paniculata , also known as Chuan Xin Lian, has traditionally been used as an anti-inflammatory and antibacterial herb for centuries and has recently been classified as a promising herbal remedy for adjuvant therapy in treating respiratory diseases. This study aimed to screen Chuan Xin Lian’s bioactive components and elicit the potential pharmacological mechanisms and plausible pathways for treating COVID-19 using network pharmacology combined with molecular docking. The results found terpenoid (andrographolide) and flavonoid (luteolin, quercetin, kaempferol, and wogonin) derivatives had remarkable potential against COVID-19 and sequelae owing to their high degrees in the component-target-pathway network and strong binding capacities in docking scores. In addition, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the PI3K-AKT signaling pathway might be the most vital molecular pathway in the pathophysiology of COVID-19 and long-term sequelae whereby therapeutic strategies can intervene. |
| first_indexed | 2024-04-10T23:22:34Z |
| format | Article |
| id | doaj.art-f18a7db2676442e7816c844b72e5704c |
| institution | Directory Open Access Journal |
| issn | 1177-9322 |
| language | English |
| last_indexed | 2024-04-10T23:22:34Z |
| publishDate | 2023-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Bioinformatics and Biology Insights |
| spelling | doaj.art-f18a7db2676442e7816c844b72e5704c2023-01-12T13:34:17ZengSAGE PublishingBioinformatics and Biology Insights1177-93222023-01-011710.1177/11779322221149622The Potential of Ameliorating COVID-19 and Sequelae From via BioinformaticsHien Thi Nguyen0Van Mai Do1Thanh Thuy Phan2Dung Tam Nguyen Huynh3Faculty of Public Health, Can Tho University of Medicine and Pharmacy, Can Tho, VietnamFaculty of Traditional Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, VietnamFaculty of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh City, VietnamSchool of Pharmacy, College of Pharmacy, Taipei Medical University, TaipeiThe current coronavirus disease 2019 (COVID-19) outbreak is alarmingly escalating and raises challenges in finding efficient compounds for treatment. Repurposing phytochemicals in herbs is an ideal and economical approach for screening potential herbal components against COVID-19. Andrographis paniculata , also known as Chuan Xin Lian, has traditionally been used as an anti-inflammatory and antibacterial herb for centuries and has recently been classified as a promising herbal remedy for adjuvant therapy in treating respiratory diseases. This study aimed to screen Chuan Xin Lian’s bioactive components and elicit the potential pharmacological mechanisms and plausible pathways for treating COVID-19 using network pharmacology combined with molecular docking. The results found terpenoid (andrographolide) and flavonoid (luteolin, quercetin, kaempferol, and wogonin) derivatives had remarkable potential against COVID-19 and sequelae owing to their high degrees in the component-target-pathway network and strong binding capacities in docking scores. In addition, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the PI3K-AKT signaling pathway might be the most vital molecular pathway in the pathophysiology of COVID-19 and long-term sequelae whereby therapeutic strategies can intervene.https://doi.org/10.1177/11779322221149622 |
| spellingShingle | Hien Thi Nguyen Van Mai Do Thanh Thuy Phan Dung Tam Nguyen Huynh The Potential of Ameliorating COVID-19 and Sequelae From via Bioinformatics Bioinformatics and Biology Insights |
| title | The Potential of Ameliorating COVID-19 and Sequelae From via Bioinformatics |
| title_full | The Potential of Ameliorating COVID-19 and Sequelae From via Bioinformatics |
| title_fullStr | The Potential of Ameliorating COVID-19 and Sequelae From via Bioinformatics |
| title_full_unstemmed | The Potential of Ameliorating COVID-19 and Sequelae From via Bioinformatics |
| title_short | The Potential of Ameliorating COVID-19 and Sequelae From via Bioinformatics |
| title_sort | potential of ameliorating covid 19 and sequelae from via bioinformatics |
| url | https://doi.org/10.1177/11779322221149622 |
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