Mammary γδ T cells promote IL-17A-mediated immunity against Staphylococcus aureus-induced mastitis in a microbiota-dependent manner
Summary: Mastitis, a common disease for female during lactation period that could cause a health risk for human or huge economic losses for animals, is mainly caused by S. aureus invasion. Here, we found that neutrophil recruitment via IL-17A-mediated signaling was required for host defense against...
| मुख्य लेखकों: | , , , , , , , , , , , , , , |
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| स्वरूप: | लेख |
| भाषा: | English |
| प्रकाशित: |
Elsevier
2023-12-01
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| श्रृंखला: | iScience |
| विषय: | |
| ऑनलाइन पहुंच: | http://www.sciencedirect.com/science/article/pii/S2589004223025300 |
| _version_ | 1827582107408400384 |
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| author | Na Pan Lei Xiu Ying Xu Xuemei Bao Yanchen Liang Haochi Zhang Bohui Liu Yuanyu Feng Huibo Guo Jing Wu Haotian Li Cheng Ma Shouxin Sheng Ting Wang Xiao Wang |
| author_facet | Na Pan Lei Xiu Ying Xu Xuemei Bao Yanchen Liang Haochi Zhang Bohui Liu Yuanyu Feng Huibo Guo Jing Wu Haotian Li Cheng Ma Shouxin Sheng Ting Wang Xiao Wang |
| author_sort | Na Pan |
| collection | DOAJ |
| description | Summary: Mastitis, a common disease for female during lactation period that could cause a health risk for human or huge economic losses for animals, is mainly caused by S. aureus invasion. Here, we found that neutrophil recruitment via IL-17A-mediated signaling was required for host defense against S. aureus-induced mastitis in a mouse model. The rapid accumulation and activation of Vγ4+ γδ T cells in the early stage of infection triggered the IL-17A-mediated immune response. Interestingly, the accumulation and influence of γδT17 cells in host defense against S. aureus-induced mastitis in a commensal microbiota-dependent manner. Overall, this study, focusing on γδT17 cells, clarified innate immune response mechanisms against S. aureus-induced mastitis, and provided a specific response to target for future immunotherapies. Meanwhile, a link between commensal microbiota community and host defense to S. aureus mammary gland infection may unveil potential therapeutic strategies to combat these intractable infections. |
| first_indexed | 2024-03-08T22:45:47Z |
| format | Article |
| id | doaj.art-f18cfc2d9ec44e9cb259b2577d45c04a |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T22:45:47Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-f18cfc2d9ec44e9cb259b2577d45c04a2023-12-17T06:40:52ZengElsevieriScience2589-00422023-12-012612108453Mammary γδ T cells promote IL-17A-mediated immunity against Staphylococcus aureus-induced mastitis in a microbiota-dependent mannerNa Pan0Lei Xiu1Ying Xu2Xuemei Bao3Yanchen Liang4Haochi Zhang5Bohui Liu6Yuanyu Feng7Huibo Guo8Jing Wu9Haotian Li10Cheng Ma11Shouxin Sheng12Ting Wang13Xiao Wang14State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, China; Hohhot Inspection and Testing Center, Hohhot 010070, ChinaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010000, China; Corresponding authorSummary: Mastitis, a common disease for female during lactation period that could cause a health risk for human or huge economic losses for animals, is mainly caused by S. aureus invasion. Here, we found that neutrophil recruitment via IL-17A-mediated signaling was required for host defense against S. aureus-induced mastitis in a mouse model. The rapid accumulation and activation of Vγ4+ γδ T cells in the early stage of infection triggered the IL-17A-mediated immune response. Interestingly, the accumulation and influence of γδT17 cells in host defense against S. aureus-induced mastitis in a commensal microbiota-dependent manner. Overall, this study, focusing on γδT17 cells, clarified innate immune response mechanisms against S. aureus-induced mastitis, and provided a specific response to target for future immunotherapies. Meanwhile, a link between commensal microbiota community and host defense to S. aureus mammary gland infection may unveil potential therapeutic strategies to combat these intractable infections.http://www.sciencedirect.com/science/article/pii/S2589004223025300ImmunologyComponents of the immune systemBacteriologyTranscriptomics |
| spellingShingle | Na Pan Lei Xiu Ying Xu Xuemei Bao Yanchen Liang Haochi Zhang Bohui Liu Yuanyu Feng Huibo Guo Jing Wu Haotian Li Cheng Ma Shouxin Sheng Ting Wang Xiao Wang Mammary γδ T cells promote IL-17A-mediated immunity against Staphylococcus aureus-induced mastitis in a microbiota-dependent manner iScience Immunology Components of the immune system Bacteriology Transcriptomics |
| title | Mammary γδ T cells promote IL-17A-mediated immunity against Staphylococcus aureus-induced mastitis in a microbiota-dependent manner |
| title_full | Mammary γδ T cells promote IL-17A-mediated immunity against Staphylococcus aureus-induced mastitis in a microbiota-dependent manner |
| title_fullStr | Mammary γδ T cells promote IL-17A-mediated immunity against Staphylococcus aureus-induced mastitis in a microbiota-dependent manner |
| title_full_unstemmed | Mammary γδ T cells promote IL-17A-mediated immunity against Staphylococcus aureus-induced mastitis in a microbiota-dependent manner |
| title_short | Mammary γδ T cells promote IL-17A-mediated immunity against Staphylococcus aureus-induced mastitis in a microbiota-dependent manner |
| title_sort | mammary γδ t cells promote il 17a mediated immunity against staphylococcus aureus induced mastitis in a microbiota dependent manner |
| topic | Immunology Components of the immune system Bacteriology Transcriptomics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223025300 |
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