An update on the potential for male contraception: emerging options
Deborah A Garside,1 Ayman Gebril,2 Manal Alsaadi,2 Natalie Nimmo,2 Alexander B Mullen,2 Valerie A Ferro2 1Imperial College London, Faculty of Medicine, London, 2University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, UK Abstract: The human population continues...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2013-04-01
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| Series: | Open Access Journal of Contraception |
| Online Access: | http://www.dovepress.com/an-update-on-the-potential-for-male-contraception-emerging-options-a12724 |
| _version_ | 1819033057248673792 |
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| author | Garside DA Gebril A Alsaadi M Nimmo N Mullen AB Ferro VA |
| author_facet | Garside DA Gebril A Alsaadi M Nimmo N Mullen AB Ferro VA |
| author_sort | Garside DA |
| collection | DOAJ |
| description | Deborah A Garside,1 Ayman Gebril,2 Manal Alsaadi,2 Natalie Nimmo,2 Alexander B Mullen,2 Valerie A Ferro2 1Imperial College London, Faculty of Medicine, London, 2University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, UK Abstract: The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women. Current options available to men include withdrawal, condoms, and vasectomy. Methods in development fall into two categories: hormonal and nonhormonal. This review will provide an overview of the testosterone combinations and immunocontraception of hormonal targets. Nonhormonal immunocontraception of sperm proteins will also be examined, together with the use of agents to disrupt other sperm-associated targets and pathways. The categories focused on include epididymal proteins, testicular kinases, epigenetic reader proteins, opioids, lonidamine derivatives, retinoic acid, microRNAs associated with spermatogenesis, and plant extracts. Considering these developments, the number of options available to men is likely to increase in the near future. Keywords: hormonal, immunocontraception, nonhormonal contraceptives |
| first_indexed | 2024-12-21T07:11:47Z |
| format | Article |
| id | doaj.art-f18d2b0b3fbd42c3bc4aadd97a2cc74f |
| institution | Directory Open Access Journal |
| issn | 1179-1527 |
| language | English |
| last_indexed | 2024-12-21T07:11:47Z |
| publishDate | 2013-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Open Access Journal of Contraception |
| spelling | doaj.art-f18d2b0b3fbd42c3bc4aadd97a2cc74f2022-12-21T19:11:57ZengDove Medical PressOpen Access Journal of Contraception1179-15272013-04-012013default111An update on the potential for male contraception: emerging optionsGarside DAGebril AAlsaadi MNimmo NMullen ABFerro VADeborah A Garside,1 Ayman Gebril,2 Manal Alsaadi,2 Natalie Nimmo,2 Alexander B Mullen,2 Valerie A Ferro2 1Imperial College London, Faculty of Medicine, London, 2University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, UK Abstract: The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women. Current options available to men include withdrawal, condoms, and vasectomy. Methods in development fall into two categories: hormonal and nonhormonal. This review will provide an overview of the testosterone combinations and immunocontraception of hormonal targets. Nonhormonal immunocontraception of sperm proteins will also be examined, together with the use of agents to disrupt other sperm-associated targets and pathways. The categories focused on include epididymal proteins, testicular kinases, epigenetic reader proteins, opioids, lonidamine derivatives, retinoic acid, microRNAs associated with spermatogenesis, and plant extracts. Considering these developments, the number of options available to men is likely to increase in the near future. Keywords: hormonal, immunocontraception, nonhormonal contraceptiveshttp://www.dovepress.com/an-update-on-the-potential-for-male-contraception-emerging-options-a12724 |
| spellingShingle | Garside DA Gebril A Alsaadi M Nimmo N Mullen AB Ferro VA An update on the potential for male contraception: emerging options Open Access Journal of Contraception |
| title | An update on the potential for male contraception: emerging options |
| title_full | An update on the potential for male contraception: emerging options |
| title_fullStr | An update on the potential for male contraception: emerging options |
| title_full_unstemmed | An update on the potential for male contraception: emerging options |
| title_short | An update on the potential for male contraception: emerging options |
| title_sort | update on the potential for male contraception emerging options |
| url | http://www.dovepress.com/an-update-on-the-potential-for-male-contraception-emerging-options-a12724 |
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