Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases
Medical ozone reestablishes cellular redox balance so that it may be a valid therapeutic approach in the prevention and management of age-related diseases with oxidative etiology in older people. The aim of this study is to evaluate oxidative stress and some vasoactive substances in elderly (60–70 y...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1029805/full |
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| author | Olga Sonia León Fernández Gabriel Takon Oru Renate Viebahn-Hänsler Gilberto López Cabreja Irainis Serrano Espinosa Elizabeth García Fernández |
| author_facet | Olga Sonia León Fernández Gabriel Takon Oru Renate Viebahn-Hänsler Gilberto López Cabreja Irainis Serrano Espinosa Elizabeth García Fernández |
| author_sort | Olga Sonia León Fernández |
| collection | DOAJ |
| description | Medical ozone reestablishes cellular redox balance so that it may be a valid therapeutic approach in the prevention and management of age-related diseases with oxidative etiology in older people. The aim of this study is to evaluate oxidative stress and some vasoactive substances in elderly (60–70 years) rheumatoid arthritis patients with diabetes and hypertension, as well as another group with bronchial asthma patients in order to demonstrate the beneficial effects of medical ozone in the prevention and therapy of age-related diseases in these age groups. A randomized clinical study with 45 older patients (60–70 years) was performed. Group I (n = 15) with rheumatoid arthritis + diabetes and hypertension received no ozone treatment, and group II (n = 30) was treated with medical ozone. This group was divided into two subgroups (n = 15 each), group IIa: the same as group I + medical ozone and group IIb: bronchial asthma patients. Indicators of RA in I and IIa groups were evaluated. Redox balance was assessed through defense and injury biomarkers. Thromboxane A2 (TXA2) and prostacyclin levels were assessed in group IIb patients. Medical ozone arrested oxidative injury progression in the Ia group and decreased thromboxane levels and the TXA2/6-keto PGF1α ratio in the IIb group. Medical ozone arrested the progression of oxidative damage and modulated those endogenous mechanisms that promote a suitable redox status and TXA2/PGI2 balance. These results suggest that medical ozone may become a standard approach in the prevention and management of age-related oxidative diseases in elderly people. |
| first_indexed | 2024-04-12T14:13:42Z |
| format | Article |
| id | doaj.art-f18e30f1f7574f2cb7277e5732e24efe |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T14:13:42Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-f18e30f1f7574f2cb7277e5732e24efe2022-12-22T03:29:48ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-11-011310.3389/fphys.2022.10298051029805Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseasesOlga Sonia León Fernández0Gabriel Takon Oru1Renate Viebahn-Hänsler2Gilberto López Cabreja3Irainis Serrano Espinosa4Elizabeth García Fernández5Pharmacy and Food Institute, University of Havana, Havana, CubaPharmacy and Food Institute, University of Havana, Havana, CubaMedical Society for the Use of Ozone in Prevention and Therapy, Iffezheim/Baden- Baden, GermanyNational Institute of Rheumatology, Ministry of Public Health, Havana, CubaNational Institute of Rheumatology, Ministry of Public Health, Havana, CubaPharmacy and Food Institute, University of Havana, Havana, CubaMedical ozone reestablishes cellular redox balance so that it may be a valid therapeutic approach in the prevention and management of age-related diseases with oxidative etiology in older people. The aim of this study is to evaluate oxidative stress and some vasoactive substances in elderly (60–70 years) rheumatoid arthritis patients with diabetes and hypertension, as well as another group with bronchial asthma patients in order to demonstrate the beneficial effects of medical ozone in the prevention and therapy of age-related diseases in these age groups. A randomized clinical study with 45 older patients (60–70 years) was performed. Group I (n = 15) with rheumatoid arthritis + diabetes and hypertension received no ozone treatment, and group II (n = 30) was treated with medical ozone. This group was divided into two subgroups (n = 15 each), group IIa: the same as group I + medical ozone and group IIb: bronchial asthma patients. Indicators of RA in I and IIa groups were evaluated. Redox balance was assessed through defense and injury biomarkers. Thromboxane A2 (TXA2) and prostacyclin levels were assessed in group IIb patients. Medical ozone arrested oxidative injury progression in the Ia group and decreased thromboxane levels and the TXA2/6-keto PGF1α ratio in the IIb group. Medical ozone arrested the progression of oxidative damage and modulated those endogenous mechanisms that promote a suitable redox status and TXA2/PGI2 balance. These results suggest that medical ozone may become a standard approach in the prevention and management of age-related oxidative diseases in elderly people.https://www.frontiersin.org/articles/10.3389/fphys.2022.1029805/fullozoneagingoxidative diseaseselderly peopleredox status |
| spellingShingle | Olga Sonia León Fernández Gabriel Takon Oru Renate Viebahn-Hänsler Gilberto López Cabreja Irainis Serrano Espinosa Elizabeth García Fernández Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases Frontiers in Physiology ozone aging oxidative diseases elderly people redox status |
| title | Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases |
| title_full | Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases |
| title_fullStr | Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases |
| title_full_unstemmed | Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases |
| title_short | Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases |
| title_sort | medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients 60 70 years with oxidative etiology diseases |
| topic | ozone aging oxidative diseases elderly people redox status |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1029805/full |
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