Extensive frontal focused ultrasound mediated blood–brain barrier opening for the treatment of Alzheimer’s disease: a proof-of-concept study

Extensive frontal focused ultrasound mediated blood–brain barrier opening for the treatment of Alzheimer’s disease: a proof-of-concept study

Abstract Background Focused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening has shown efficacy in removal of amyloid plaque and improvement of cognitive functions in preclinical studies, but this is rarely reported in clinical studies. This study was conducted to evaluate the safety, fea...

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Bibliographic Details
Main Authors: So Hee Park, Kyoungwon Baik, Seun Jeon, Won Seok Chang, Byoung Seok Ye, Jin Woo Chang
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer disease
Focused ultrasound
Blood–brain barrier
Amyloid beta-peptides
Online Access:https://doi.org/10.1186/s40035-021-00269-8

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