Estimation and correlation of procalcitonin in saliva and serum of chronic periodontitis patients before and after nonsurgical periodontal therapy: An analytical comparative study
Background: Procalcitonin (ProCT) is an emerging inflammatory biomarker in bacterial infections. Few studies have reported raising salivary ProCT in periodontitis patients. Hence, the study aims to analyze and correlate the changes in saliva and serum ProCT in periodontitis patients before and after...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Indian Society of Periodontology |
| Subjects: | |
| Online Access: | http://www.jisponline.com/article.asp?issn=0972-124X;year=2021;volume=25;issue=1;spage=29;epage=33;aulast=Renjith |
| _version_ | 1818337097948332032 |
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| author | Ambili Renjith Laljyothi Sujatha |
| author_facet | Ambili Renjith Laljyothi Sujatha |
| author_sort | Ambili Renjith |
| collection | DOAJ |
| description | Background: Procalcitonin (ProCT) is an emerging inflammatory biomarker in bacterial infections. Few studies have reported raising salivary ProCT in periodontitis patients. Hence, the study aims to analyze and correlate the changes in saliva and serum ProCT in periodontitis patients before and after nonsurgical periodontal therapy. Materials and Methods: We have included 15 chronic periodontitis patients of mean age 41.8 ± 6.82 years who satisfy the inclusion criteria in the study. After saliva and serum collection, clinical parameters such as plaque index, gingival index, gingival bleeding index, probing pocket depth, and clinical attachment were recorded, and scaling and root debridement were performed. Reevaluation was done at 1- and 3-month interval. ProCT was estimated using the enzyme-linked immunosorbent assay. Results: Salivary ProCT was significantly greater than its serum counterpart at baseline and 1 month after periodontal therapy (0.20 vs. 0.26, 0.13 vs. 0.14 ng/ml respectively). We noticed a significant reduction in salivary as well as serum ProCT (35% and 46%, respectively) 1 month after scaling and root debridement. A significant moderate positive correlation was found between paired observations of salivary and serum ProCT at baseline as well as after periodontal therapy (r = 0.61 and 0.7). A further reduction of salivary ProCT was noticed 3 months after nonsurgical therapy (0.11 ng/ml). Conclusions: Serum ProCT significantly decreases with periodontal treatment, indicating the impact of periodontal therapy on systemic inflammation. Since salivary ProCT is positively correlated with serum ProCT, we can consider it as an alternative biomarker to its serum counterpart. |
| first_indexed | 2024-12-13T14:49:48Z |
| format | Article |
| id | doaj.art-f18f2d9253534591905ab9095371a91d |
| institution | Directory Open Access Journal |
| issn | 0972-124X |
| language | English |
| last_indexed | 2024-12-13T14:49:48Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Society of Periodontology |
| spelling | doaj.art-f18f2d9253534591905ab9095371a91d2022-12-21T23:41:22ZengWolters Kluwer Medknow PublicationsJournal of Indian Society of Periodontology0972-124X2021-01-01251293310.4103/jisp.jisp_166_20Estimation and correlation of procalcitonin in saliva and serum of chronic periodontitis patients before and after nonsurgical periodontal therapy: An analytical comparative studyAmbili RenjithLaljyothi SujathaBackground: Procalcitonin (ProCT) is an emerging inflammatory biomarker in bacterial infections. Few studies have reported raising salivary ProCT in periodontitis patients. Hence, the study aims to analyze and correlate the changes in saliva and serum ProCT in periodontitis patients before and after nonsurgical periodontal therapy. Materials and Methods: We have included 15 chronic periodontitis patients of mean age 41.8 ± 6.82 years who satisfy the inclusion criteria in the study. After saliva and serum collection, clinical parameters such as plaque index, gingival index, gingival bleeding index, probing pocket depth, and clinical attachment were recorded, and scaling and root debridement were performed. Reevaluation was done at 1- and 3-month interval. ProCT was estimated using the enzyme-linked immunosorbent assay. Results: Salivary ProCT was significantly greater than its serum counterpart at baseline and 1 month after periodontal therapy (0.20 vs. 0.26, 0.13 vs. 0.14 ng/ml respectively). We noticed a significant reduction in salivary as well as serum ProCT (35% and 46%, respectively) 1 month after scaling and root debridement. A significant moderate positive correlation was found between paired observations of salivary and serum ProCT at baseline as well as after periodontal therapy (r = 0.61 and 0.7). A further reduction of salivary ProCT was noticed 3 months after nonsurgical therapy (0.11 ng/ml). Conclusions: Serum ProCT significantly decreases with periodontal treatment, indicating the impact of periodontal therapy on systemic inflammation. Since salivary ProCT is positively correlated with serum ProCT, we can consider it as an alternative biomarker to its serum counterpart.http://www.jisponline.com/article.asp?issn=0972-124X;year=2021;volume=25;issue=1;spage=29;epage=33;aulast=Renjithacute phase reactantchronic periodontitisprocalcitoninsalivascaling and root debridementserum |
| spellingShingle | Ambili Renjith Laljyothi Sujatha Estimation and correlation of procalcitonin in saliva and serum of chronic periodontitis patients before and after nonsurgical periodontal therapy: An analytical comparative study Journal of Indian Society of Periodontology acute phase reactant chronic periodontitis procalcitonin saliva scaling and root debridement serum |
| title | Estimation and correlation of procalcitonin in saliva and serum of chronic periodontitis patients before and after nonsurgical periodontal therapy: An analytical comparative study |
| title_full | Estimation and correlation of procalcitonin in saliva and serum of chronic periodontitis patients before and after nonsurgical periodontal therapy: An analytical comparative study |
| title_fullStr | Estimation and correlation of procalcitonin in saliva and serum of chronic periodontitis patients before and after nonsurgical periodontal therapy: An analytical comparative study |
| title_full_unstemmed | Estimation and correlation of procalcitonin in saliva and serum of chronic periodontitis patients before and after nonsurgical periodontal therapy: An analytical comparative study |
| title_short | Estimation and correlation of procalcitonin in saliva and serum of chronic periodontitis patients before and after nonsurgical periodontal therapy: An analytical comparative study |
| title_sort | estimation and correlation of procalcitonin in saliva and serum of chronic periodontitis patients before and after nonsurgical periodontal therapy an analytical comparative study |
| topic | acute phase reactant chronic periodontitis procalcitonin saliva scaling and root debridement serum |
| url | http://www.jisponline.com/article.asp?issn=0972-124X;year=2021;volume=25;issue=1;spage=29;epage=33;aulast=Renjith |
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